Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shizuka Ishitani"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In vertebrate embryos, the canonical Wnt ligand primes the formation of dorsal organizers that govern dorsal-ventral patterns by secreting BMP antagonists. In contrast, in Drosophila embryos, Toll-like receptor (Tlr)-mediated NFκB activatio
Externí odkaz:
https://doaj.org/article/e2d4ac2d79f44553aa1966d0083df599
Autor:
Yuki Akieda, Shohei Ogamino, Hironobu Furuie, Shizuka Ishitani, Ryutaro Akiyoshi, Jumpei Nogami, Takamasa Masuda, Nobuyuki Shimizu, Yasuyuki Ohkawa, Tohru Ishitani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Gradients of morphogens such as Wnt provide instructive cues for cell identities during development. Here, the authors report that in the developing zebrafish embryo, cell competition and elimination of unfit cells are required for proper Wnt gradien
Externí odkaz:
https://doaj.org/article/b8bdf608e4c044408a0b01088889fa79
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1391-1404 (2014)
The phosphoprotein Dishevelled (Dvl) is a common essential component of Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. However, the regulation and significance of Dvl phosphorylation are not fully understood. Here, we show that
Externí odkaz:
https://doaj.org/article/c79703a5e8af4efdb6621875345ff5bb
Autor:
Denise Horn, Anna-Elina Lehesjoki, Janina Gburek-Augustat, Amarilis Sanchez-Valle, Kenjiro Kosaki, Katherine Anderson, Anna-Kaisa Anttonen, Tohru Ishitani, Katja Kloth, Manuel Holtgrewe, Sora Harako, Rhonda E. Schnur, Maria J. Guillen Sacoto, Yutaka Hirose, Seiji Mizuno, Shizuka Ishitani, Kota Abe, Tadashi Kaname, Yusaku Kaido, Johannes Luppe, Nadja Ehmke, Michelle M. Morrow, John Pappas, Tatjana Bierhals, Masayuki Oginuma, David Viskochil, Yoshiaki Ohkuma, Tomoko Uehara, Konrad Platzer, Courtney L. Edgar-Zarate, Rachel Rabin, Yuri A. Zarate, Mikko Muona, Nobuhiko Okamoto
Publikováno v:
Genetics in Medicine. 23:1050-1057
Purpose To expand the recent description of a new neurodevelopmental syndrome related to alterations in CDK19. Methods Individuals were identified through international collaboration. Functional studies included autophosphorylation assays for CDK19 G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5813c2192055f297fcafe358e6d9a2ec
https://doi.org/10.1038/s41436-020-01091-9
https://doi.org/10.1038/s41436-020-01091-9
Autor:
Shizuka Ishitani, Kenjiro Kosaki, Sachiko Nishina, Kaoru Tomita, Tohru Ishitani, Maki Fukami, Tadashi Yokoi, Tsutomu Ogata, Hirotomo Saitsu, Yoshihiro Hotta, Katsuhiro Hosono, Noriyuki Azuma, Tomoyo Yoshida
Publikováno v:
Journal of Human Genetics
CDK9 has been considered a candidate gene involved in the CHARGE-like syndrome in a pair of cousins. We report an 8-year-old boy with a strikingly similar phenotype including facial asymmetry, microtia with preauricular tags and bilateral hearing los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb38c6ff2b30acd49b710687c4f52b8
https://doi.org/10.1038/s10038-021-00909-x
https://doi.org/10.1038/s10038-021-00909-x
Autor:
Jumpei Nogami, Yasuyuki Ohkawa, Tohru Ishitani, Takamasa Masuda, Ryutaro Akiyoshi, Hironobu Furuie, Shizuka Ishitani, Shohei Ogamino, Yuki Akieda, Nobuyuki Shimizu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Morphogen signalling forms an activity gradient and instructs cell identities in a signalling strength-dependent manner to pattern developing tissues. However, developing tissues also undergo dynamic morphogenesis, which may produce cells with unfit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e3150163ad5156e16411661f5b1dc9
https://doaj.org/article/b8bdf608e4c044408a0b01088889fa79
https://doaj.org/article/b8bdf608e4c044408a0b01088889fa79
Autor:
Kenjiro Kosaki, Kota Abe, Tohru Ishitani, Shizuka Ishitani, Toshiki Takenouchi, Masayuki Oginuma, Tomoko Uehara, Nobuhiko Okamoto, Hiroshi Yoshihashi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Cyclin-dependent kinase 8 (CDK8) is a member of the CDK/Cyclin module of the mediator complex. A recent study reported that heterozygous missense CDK8 mutations cause a neurodevelopmental disorder in humans. The mechanistic basis of CDK8-related diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1743c839722af017a2bb728ba5f57af
https://doi.org/10.1038/s41598-020-74642-4
https://doi.org/10.1038/s41598-020-74642-4
Autor:
Nobuyuki Shimizu, Hironobu Furuie, Jumpei Nogami, Tohru Ishitani, Yasuyuki Ohkawa, Shohei Ogamino, Ryutaro Akiyoshi, Takamasa Masuda, Yuki Akieda, Shizuka Ishitani
SUMMARYMorphogen signaling forms an activity gradient and instructs cell identities in a signaling strength-dependent manner to pattern developing tissues. However, developing tissues also undergo dynamic morphogenesis, which may produce cells with u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8c03d25c78a1710dee25d49a9fa004
https://doi.org/10.1101/423814
https://doi.org/10.1101/423814
Autor:
Tohru Ishitani, Shizuka Ishitani
Publikováno v:
Encyclopedia of Signaling Molecules ISBN: 9781461464389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::697ad604d22f6ee44eed82cad380057a
https://doi.org/10.1007/978-1-4614-6438-9_101750-1
https://doi.org/10.1007/978-1-4614-6438-9_101750-1