Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shiyun Pu"'
Autor:
Xuping Yang, Qinhui Liu, Yanping Li, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Yingnan Zhao, Guorong Zhang, Cuiyuan Huang, Jinhang Zhang, Zijing Zhang, Ya Huang, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan He
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 484-494 (2020)
The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary glucose excretion and thus reducing hyperglycaemia. Cana treatment also reduces body weight. However, it remains unclear w
Externí odkaz:
https://doaj.org/article/6af5c4ed9b494dcbaec0f4ee17d251b8
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several aging-related diseases, such as Alzheimer’s disease, kidney injury, cancer, chronic obstructi
Externí odkaz:
https://doaj.org/article/fff787973595474aae3e5ff1e616b665
Autor:
Shiyun Pu, Yanping Li, Qinhui Liu, Xu Zhang, Lei Chen, Rui Li, Jinhang Zhang, Tong Wu, Qin Tang, Xuping Yang, Zijing Zhang, Ya Huang, Jiangying Kuang, Hong Li, Min Zou, Wei Jiang, Jinhan He
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes. In this study, we examined the role of 5-LO in HSC ac
Externí odkaz:
https://doaj.org/article/5d4b3915c3bf4b0ebd852a77c304c260
Autor:
Qin Tang, Yong Gao, Qinhui Liu, Xuping Yang, Tong Wu, Cuiyuan Huang, Ya Huang, Jinhang Zhang, Zijing Zhang, Rui Li, Shiyun Pu, Guorong Zhang, Yingnan Zhao, Jian Zhou, Hui Huang, Yanping Li, Wei Jiang, Yongsheng Chang, Jinhan He
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100994- (2020)
Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been establish
Externí odkaz:
https://doaj.org/article/82d10c381a254b99a579af28b2459b29
Autor:
Shiyun Pu, Qinhui Liu, Yanping Li, Rui Li, Tong Wu, Zijing Zhang, Cuiyuan Huang, Xuping Yang, Jinhan He
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug. Overdose of APAP is the leading cause of hospital admission for acute liver failure. Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (Cysltr1), wh
Externí odkaz:
https://doaj.org/article/f951e756887a42429038e03f5b1f5a61
Autor:
Hong Li, Jing Shen, Tong Wu, Jiangying Kuang, Qinhui Liu, Shihai Cheng, Shiyun Pu, Lei Chen, Rui Li, Yanping Li, Min Zou, Zhiyong Zhang, Wei Jiang, Aijuan Qu, Jinhan He
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treate
Externí odkaz:
https://doaj.org/article/7943583ff535430187f1f89165526aab
Publikováno v:
Future Medicinal Chemistry. 15:395-397
Autor:
Shiyun Pu, Jingyi Zhang, Changyu Ren, Hongjing Zhou, Yan Wang, Yuanli Wu, Shuangyu Yang, Fangyin Cao, Houfeng Zhou
Publikováno v:
Life Sciences. 325:121772
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several aging-related diseases, such as Alzheimer’s disease, kidney injury, cancer, chronic obstructi
Publikováno v:
Expert review of gastroenterologyhepatology. 15(8)
Introduction: Hepatic stellate cells (HSCs) are essential for physiological homeostasis of the liver extracellular matrix (ECM). Excessive transdifferentiation of HSC from a quiescent to an activated phenotype contributes to disrupt this balance and