Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shiyin Yee"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 60:408-416
To evaluate the pharmacokinetics, pharmacodynamics (PD), safety, and tolerability of epidural SP-102 (10 mg dexamethasone sodium phosphate injectable gel) compared to an intravenous injection of 10 mg dexamethasone sodium phosphate, USP (IV USP).Subj
Autor:
Takashi Sasaki, Yasuhiro Yamada, Jun Kotera, Hirotaka Inoue, Hideki Mochida, Kohei Kikkawa, Shiyin Yee, Kotomi Fujishige, Tsunehisa Noto, Kenji Omori, Koki Kojima, Tamaki Kobayashi
Publikováno v:
Journal of Urology. 188:668-674
We investigated the in vitro inhibitory effects of avanafil, a novel, potent inhibitor of phosphodiesterase-5, on 11 phosphodiesterases. We also studied its potentiation of penile tumescence in dogs.Phosphodiesterase assay was done with the 4 phospho
Publikováno v:
Drug Metabolism and Disposition. 35:2242-2251
[7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) is a novel multi-targeted Src family kinase inhibitor with demonstrated anticancer activity in preclinical species. Potent kinase inhib
Autor:
Joel Renick, Jianguo Cao, Michael D. Martin, John Doukas, Ahmed A Kousba, Binqi Zeng, John Hood, Steven Hu, Daniel L. Lohse, Xiyun Yu, Arek Tabak, Glenn Noronha, Shiyin Yee, Richard Soll, Andrew McPherson
Publikováno v:
Drug Metabolism and Disposition. 35:929-936
TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) is a novel multitargeted, orally active protein tyrosine kinase inhibitor. The inhibition constants (K(i)) of TG100435 against Src, Lyn
Autor:
Shiyin Yee
Publikováno v:
Pharmaceutical Research. 14:763-766
Purpose. To evaluate and optimize the use of Caco-2 cell monolayers to predict thein vivo absorption of a broad range of compounds in man.
Publikováno v:
The Journal of urology. 190(2)
We evaluated the effects of the highly selective phosphodiesterase type 5 inhibitor avanafil on electroretinogram and hemodynamics in dogs, and compared the effects with those of sildenafil.Three experiments were performed in anesthetized dogs, inclu
Autor:
Shiyin Yee, Run Wang, Wesley W. Day, Craig A. Peterson, Kenji Omori, Kohei Kikkawa, Warren H. Heller, Karen DiDonato, Jun Kotera, Arthur L. Burnett
Publikováno v:
The journal of sexual medicine. 9(8)
Introduction Phosphodiesterase type 5 (PDE5) inhibitors are indicated for the treatment of erectile dysfunction (ED); however, they can also inhibit other PDE isozymes, affecting their target tissues (e.g., PDE1: heart; PDE6: retina; and PDE11: skele
Autor:
Gordon L. Amidon, Sujatha Menon, Peggy L. Carver, Chandrasekharan Ramachandran, Lynda S. Welage, Shiyin Yee, David R. Foster, Barry E. Bleske, Michael J. Shea
Publikováno v:
Journal of clinical pharmacology. 49(3)
Intestinal peptide transporters, including hPEPT1, facilitate the absorption of cephalosporins and angiotensin-converting enzyme inhibitors, and have been investigated as a means to improve oral drug absorption. Renal peptide transporters including h
Autor:
Lea Scheppke, Michael Martin, Sara M. Weis, Jon Cao, David A. Cheresh, Martin Friedlander, John Hood, Richard Soll, Shiyin Yee, R.F. Gariano, Edith Aguilar, Glenn Noronha, Ruth Jacobson, John Doukas
Publikováno v:
Journal of Clinical Investigation.
Retinal and choroidal vascular diseases, with their associated abnormalities in vascular permeability, account for the majority of patients with vision loss in industrialized nations. VEGF is upregulated in ischemic retinopathies such as diabetes and
Autor:
Ved P. Pathak, Chun P. Chow, Shiyin Yee, Michael D. Martin, Binqi Zeng, Hong Zhu, Shu Kachi, John Doukas, Naoyasu Umeda, Andrew McPherson, Dellamary Luis A, Hideo Akiyama, J. Hood, Boris Klebansky, Moorthy S.S. Palanki, Richard M. Fine, Katsutoshi Yokoi, Peter A. Campochiaro, Ahmed A Kousba, Joel Renick, Glenn Noronha, Dan Lohse, Xinshan Kang, Richard M. Soll, Colleen Gritzen, Chi Ching Mak, Steven Hu, Jianguo Cao
Publikováno v:
Journal of medicinal chemistry. 51(6)
Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to treat AMD has been validated clinically. A large body of evidence suggests that inhibitors ta