Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shivraj M. Yabaji"'
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101241- (2022)
Summary: Here, we present a streamlined protocol for assessing intracellular Mycobacterium tuberculosis (Mtb) loads in macrophages. This protocol describes the simultaneous assessment of macrophage viability using automated microscopy. Further, we de
Externí odkaz:
https://doaj.org/article/4e3866684c0f461bbf6caa4f2316d07e
Autor:
Sujoy Chatterjee, Shivraj M. Yabaji, Oleksii S. Rukhlenko, Bidisha Bhattacharya, Emily Waligurski, Nandini Vallavoju, Somak Ray, Boris N. Kholodenko, Lauren E. Brown, Aaron B. Beeler, Alexander R. Ivanov, Lester Kobzik, John A. Porco, Jr., Igor Kramnik
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102845- (2021)
Summary: Macrophages contribute to host immunity and tissue homeostasis via alternative activation programs. M1-like macrophages control intracellular bacterial pathogens and tumor progression. In contrast, M2-like macrophages shape reparative microe
Externí odkaz:
https://doaj.org/article/a1f35f552f1f482fb68b000a8206985c
Autor:
Raymond Rosenbloom, Igor Gavrish, Anna E. Tseng, Kerstin Seidel, Shivraj M. Yabaji, Hans P. Gertje, Bertrand R. Huber, Igor Kramnik, Nicholas A. Crossland
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5999 (2022)
Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are a growing public health concern with incidence and mortality steadily increasing globally. Granulomatous inflammation is the hallma
Externí odkaz:
https://doaj.org/article/73d4044ecf9f4e72bc13f0c9c4db0f1f
Autor:
Shivraj M. Yabaji, Oleksii S. Rukhlenko, Sujoy Chatterjee, Bidisha Bhattacharya, Emily Wood, Marina Kasaikina, Boris Kholodenko, Alexander A. Gimelbrant, Igor Kramnik
Publikováno v:
bioRxiv
Understanding cell state transitions and purposefully controlling them to improve therapies is a longstanding challenge in biological research and medicine. Here, we identify a transcriptional signature that distinguishes activated macrophages from T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b812ba158ea372e3e5ffe06984f70893
https://doi.org/10.1101/2023.02.09.527908
https://doi.org/10.1101/2023.02.09.527908
Autor:
Kishore K. Srivastava, Shivraj M. Yabaji, Kanchan Srivastava, Ekta Dhamija, Alok K. Mishra, Dheeraj Soam, Rikesh K. Dubey
Publikováno v:
Mitochondrion. 57:241-256
Mycobacterium tuberculosis (Mtb) employs diverse strategies to survive inside the host macrophages. In this study, we have identified a conserved hypothetical protein of Mtb; Rv0674, which is present in the mitochondria of the host cell. The genetic
Publikováno v:
Preparative Biochemistry & Biotechnology
The causative agent of novel coronavirus disease (COVID-19) is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 possesses RNA as a genetic material with 79% of the match with the bat SARS-CoV genome, which became epidemic
Autor:
Bidisha Bhattacharya, Lester Kobzik, Lauren E. Brown, Shivraj M. Yabaji, Aaron B. Beeler, Emily Waligurski, John A. Porco, Nandini Vallavoju, Somak Ray, Alexander R. Ivanov, Sujoy Chatterjee, Igor Kramnik, Boris N. Kholodenko, Oleksii S. Rukhlenko
Publikováno v:
iScience
iScience, Vol 24, Iss 8, Pp 102845-(2021)
iScience, Vol 24, Iss 8, Pp 102845-(2021)
Summary Macrophages contribute to host immunity and tissue homeostasis via alternative activation programs. M1-like macrophages control intracellular bacterial pathogens and tumor progression. In contrast, M2-like macrophages shape reparative microen
Autor:
Ekta Dhamija, Aditi Chatterjee, Shivraj M. Yabaji, Swati Jaiswal, Kishore K. Srivastava, Sapna Pandey
Publikováno v:
Biochimie. 165:156-160
Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatase (PtpA) has so far been known to control intracellular survival of mycobacteria; whereas the ATP synthase which is essential for mycobacterial growth has recently been contemplated in devel
Publikováno v:
Chemical Biology & Drug Design. 94:1330-1338
The correlation of mycobactericidal property of macrophages with its potential to deliver bacteria to hydrolytic lysosomes, augmented with ubiquitin-derived peptides (Ub2), activates the process of autophagy. This leads to the formation of phagolysos
Autor:
Hui A. Chen, William R. Bishai, Igor Kramnik, Sujoy Chatterjee, Alexander A. Gimelbrant, Bidisha Bhattacharya, Eric Brownhill, Boris N. Kholodenko, Kerstin Seidel, Vadim Zhernovkov, Shivraj M. Yabaji, Oleksii S. Rukhlenko, Nicholas A. Crossland, Lester Kobzik
Tuberculosis remains a critical infectious disease world-wide. The development of novel therapeutic strategies requires greater understanding of host factors that contribute to disease susceptibility. A major unknown in TB pathogenesis is the mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::996fdd2bf8437bc2971add23a790def5
https://doi.org/10.1101/2020.12.14.422743
https://doi.org/10.1101/2020.12.14.422743