Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target.

Autor: Zhang H; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: zhanghao@stanford.edu., Thai PN; Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, Davis, CA 95616, USA; David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA., Shivnaraine RV; Greenstone Biosciences, Palo Alto, CA 94305, USA., Ren L; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Wu X; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Siepe DH; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Liu Y; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Tu C; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Shin HS; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Caudal A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Mukherjee S; Greenstone Biosciences, Palo Alto, CA 94305, USA., Leitz J; Greenstone Biosciences, Palo Alto, CA 94305, USA., Wen WTL; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Liu W; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Zhu W; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Chiamvimonvat N; Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, Davis, CA 95616, USA; Department of Basic Medical Sciences and Translational Cardiovascular Research Center, University of Arizona College of Medicine, Phoenix, AZ 85004, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: joewu@stanford.edu.

Publikováno v: Cell [Cell] 2024 Dec 12; Vol. 187 (25), pp. 7143-7163.e22. Date of Electronic Publication: 2024 Oct 15.

ADMET-AI: A machine learning ADMET platform for evaluation of large-scale chemical libraries.

Autor: Swanson K, Walther P, Leitz J, Mukherjee S, Wu JC, Shivnaraine RV, Zou J

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 28. Date of Electronic Publication: 2023 Dec 28.

SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant.

Autor: Guo H; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Yu X; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Liu Y; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Paik DT; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Justesen JM; Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA., Chandy M; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Jahng JWS; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Zhang T; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Wu W; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Rwere F; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Zhao SR; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Pokhrel S; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Shivnaraine RV; Greenstone Biosciences, 3160 Porter Drive, Palo Alto, CA 94305, USA., Mukherjee S; Greenstone Biosciences, 3160 Porter Drive, Palo Alto, CA 94305, USA., Simon DJ; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Manhas A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Zhang A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA., Chen CH; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Rivas MA; Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, USA., Gross ER; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Mochly-Rosen D; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jan 25; Vol. 15 (680), pp. eabp9952. Date of Electronic Publication: 2023 Jan 25.

Allostery of atypical modulators at oligomeric G protein-coupled receptors.

Autor: Shivnaraine RV; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. rvshiv@stanford.edu.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, B163 Beckman Center, 279 Campus Drive, Stanford, CA, 94305, USA. rvshiv@stanford.edu., Kelly B; Departments of Computer Science, Molecular and Cellular Physiology, and Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, 94305, USA., Elmslie G; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA., Huang XP; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.; Department of Pharmacology, The National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Dong YJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada., Seidenberg M; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA., Wells JW; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. j.wells@utoronto.ca., Ellis J; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA. johnellis@psu.edu.; Department of Psychiatry H073, Penn State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. johnellis@psu.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Apr 29; Vol. 11 (1), pp. 9265. Date of Electronic Publication: 2021 Apr 29.

Single-Molecule Analysis of the Supramolecular Organization of the M2 Muscarinic Receptor and the Gαi1 Protein.

Autor: Shivnaraine RV; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada., Fernandes DD; Department of Physics, University of Toronto , Toronto, Ontario M5S 1A7, Canada.; Department of Chemical & Physical Sciences, University of Toronto Mississauga , Mississauga, Ontario L5L 1C6, Canada., Ji H; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada., Li Y; Department of Physics, University of Toronto , Toronto, Ontario M5S 1A7, Canada.; Department of Chemical & Physical Sciences, University of Toronto Mississauga , Mississauga, Ontario L5L 1C6, Canada., Kelly B; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada.; Krembil Research Institute, University Health Network , Toronto, Ontario M5T 2S8, Canada., Zhang Z; Department of Physics, University of Toronto , Toronto, Ontario M5S 1A7, Canada.; Department of Chemical & Physical Sciences, University of Toronto Mississauga , Mississauga, Ontario L5L 1C6, Canada., Han YR; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada., Huang F; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada., Sankar KS; Department of Physiology, University of Toronto , Toronto, Ontario M5G 1L7, Canada., Dubins DN; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada., Rocheleau JV; Department of Physiology, University of Toronto , Toronto, Ontario M5G 1L7, Canada.; Institute of Biomedical and Biomaterial Engineering, University of Toronto , Toronto, Ontario M5S 3G9, Canada., Wells JW; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada., Gradinaru CC; Department of Physics, University of Toronto , Toronto, Ontario M5S 1A7, Canada.; Department of Chemical & Physical Sciences, University of Toronto Mississauga , Mississauga, Ontario L5L 1C6, Canada.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2016 Sep 14; Vol. 138 (36), pp. 11583-98. Date of Electronic Publication: 2016 Sep 02.