Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shivender M.D. Shandilya"'
Autor:
Bruce L. Goode, Silvia Jansen, Shivender M.D. Shandilya, Maeve Tischbein, Tania V. Silvas, Celia A. Schiffer, Jill A. Zitzewitz, Sivakumar Boopathy, Daryl A. Bosco, John Landers
Publikováno v:
Proceedings of the National Academy of Sciences. 112:7984-7989
Mutations in profilin 1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS); however, the pathological mechanism of PFN1 in this fatal disease is unknown. We demonstrate that ALS-linked mutations severely destabilize the native conformatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ece63e84816a419a9bf32c86282fc3
https://doi.org/10.1073/pnas.1424108112
https://doi.org/10.1073/pnas.1424108112
Autor:
Shivender M.D. Shandilya, Hiroshi Matsuo, Reuben S. Harris, Elizabeth M. Luengas, Megumi Shigematsu, Celia A. Schiffer, Takahide Kouno, Mayuko Hara, Luan Chen, JingYing Zhang
Publikováno v:
Nature structural & molecular biology
The human APOBEC3G (A3G) DNA cytosine deaminase restricts and hypermutates DNA-based parasites including HIV-1. The viral infectivity factor (Vif) prevents restriction by triggering A3G degradation. Although the structure of the A3G catalytic domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a220ea7f5eea206a3b14802e8e446366
http://europepmc.org/articles/PMC4456288
http://europepmc.org/articles/PMC4456288
Autor:
Nese Kurt Yilmaz, Mohan Somasundaran, Brendan J. Hilbert, Takahide Kouno, Markus-Frederik Bohn, William E. Royer, Tania V. Silvas, Hiroshi Matsuo, Shivender M.D. Shandilya, Celia A. Schiffer, Brian A. Kelch
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nucleic acid editing enzymes are essential components of the immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins, and contribute to the diversification and lethality of cancers. Among these enzymes are the seven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32150fa67b2d3abeb12a6e2fef7cab6c
https://doi.org/10.1038/ncomms15024
https://doi.org/10.1038/ncomms15024
Autor:
Hiroshi Matsuo, Michael A. Carpenter, Shivender M.D. Shandilya, Rebecca M. McDougle, Mohan Somasundaran, Brett D. Anderson, Celia A. Schiffer, Takahide Kouno, Anurag Rathore, Reuben S. Harris, John S. Albin, Markus-Frederik Bohn, Ahkillah N. Davis, Leah Evans, JingYing Zhang, Yongjian Lu
Publikováno v:
Structure. 21(6):1042-1050
SummaryHuman APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In this study the crystal structure of the HIV Vif binding, catalytically active, C-terminal domain of APOBEC3F (A3F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5154dcffd2cbb06a990010936752030
Autor:
Mohan Somasundaran, Shivender M.D. Shandilya, Ming Li, Anurag Rathore, Reuben S. Harris, Celia A. Schiffer, Daniel A. Harki, Akbar Ali, Michael A. Parniak, Krishan K. Pandey, Angela L. Perkins, Jonathan Solberg, Nevan J. Krogan, Michael A. Carpenter, Jeffrey R. Johnson, William L. Brown, Derek J. Hook
Publikováno v:
ACS Chemical Biology. 7:506-517
APOBEC3G is a single-stranded DNA cytosine deaminase that comprises part of the innate immune response to viruses and transposons. Although APOBEC3G is the prototype for understanding the larger mammalian polynucleotide deaminase family, no specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8945f1c2d020beaac8604f375729d978
https://doi.org/10.1021/cb200440y
https://doi.org/10.1021/cb200440y
Autor:
Moshe Kotler, Elena Britan-Rosich, Shivender M.D. Shandilya, Celia A. Schiffer, Ponnandy Prabhu, Adi Nagler
Publikováno v:
The FEBS journal. 283(1)
The cellular cytidine deaminase APOBEC3G (A3G) was first described as an anti-HIV-1 restriction factor, acting by directly deaminating reverse transcripts of the viral genome. HIV-1 Vif neutralizes the activity of A3G, primarily by mediating degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac780e15f8d2710f8dc93f1463d54cbf
https://pubmed.ncbi.nlm.nih.gov/26460502
https://pubmed.ncbi.nlm.nih.gov/26460502
APOBEC3s (A3) are Zn2+ dependent cytidine deaminases with diverse biological functions and implications for cancer and immunity. Four of the seven human A3s restrict HIV by ‘hypermutating’ the reverse-transcribed viral genomic DNA. HIV Virion Inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2970599920815ba58539862bf27c54
https://europepmc.org/articles/PMC4857191/
https://europepmc.org/articles/PMC4857191/
Autor:
Francesca Massi, Sean P. Ryder, Carina C. Clingman, Shivender M.D. Shandilya, Samantha A Hay, Laura M. Deveau, Ryan M.J. Genga
Publikováno v:
eLife
eLife, Vol 3 (2014)
eLife, Vol 3 (2014)
Gene expression and metabolism are coupled at numerous levels. Cells must sense and respond to nutrients in their environment, and specialized cells must synthesize metabolic products required for their function. Pluripotent stem cells have the abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3743a5147b98082ada722c4316e482a
http://europepmc.org/articles/PMC4094780
http://europepmc.org/articles/PMC4094780
Autor:
William D. Thomas, Andrew Sadowski, Nese Kurt Yilmaz, Yang Wang, Shivender M.D. Shandilya, Ejemel Monir, Celia A. Schiffer, Mark S. Klempner, Zachary A. Schiller
Publikováno v:
Journal of Molecular Recognition. 30:e2595
The murine monoclonal antibody LA-2 recognizes a clinically protective epitope on outer surface protein (OspA) of Borrelia burgdorferi, the causative agent of Lyme disease in North America. Human antibody equivalence to LA-2 is the best serologic cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47ab5008b0bd5c5f421b74928b1bc7bf
https://doi.org/10.1002/jmr.2595
https://doi.org/10.1002/jmr.2595
Autor:
Ming Li, William L. Brown, Anurag Rathore, Markus-Frederik Bohn, Celia A. Schiffer, Shivender M.D. Shandilya, Allison M. Land, Emily K. Law, Michael A. Carpenter, Reuben S. Harris, Lela Lackey, Brandon Leonard
Multiple studies have indicated that the TET oxidases and, more controversially, the activation-induced cytidine deaminase/APOBEC deaminases have the capacity to convert genomic DNA 5-methylcytosine (MeC) into altered nucleobases that provoke excisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabb576acceaa3fba40e69d886e7bfb0
https://europepmc.org/articles/PMC3464582/
https://europepmc.org/articles/PMC3464582/