E. coli Fis protein insulates the cbpA gene from uncontrolled transcription.

Autor: Kiran Chintakayala, Shivani S Singh, Amanda E Rossiter, Rajesh Shahapure, Remus T Dame, David C Grainger

Publikováno v: PLoS Genetics, Vol 9, Iss 1, p e1003152 (2013)

The Escherichia coli curved DNA binding protein A (CbpA) is a poorly characterised nucleoid associated factor and co-chaperone. It is expressed at high levels as cells enter stationary phase. Using genetics, biochemistry, and genomics, we have examin

Externí odkaz: https://doaj.org/article/5ffb1e2368324accbb2dddc8776fa0d6

Properties and directionality of intragenic promoters in E. coli

Autor: Emily A. Warman, Shivani S. Singh, David C. Grainger

Publikováno v: Access Microbiology. 1

The histone-like nucleoid structuring (H-NS) protein targets and binds AT-rich DNA. Oligomerisation of H-NS along AT-rich genes represses transcription from spurious intragenic promoters within the coding sequences of AT-rich genes. In this work, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc0ea7cc1618e8836c666bcaae6dbbf7
https://doi.org/10.1099/acmi.ac2019.po0206

Widespread suppression of intragenic transcription initiation by H-NS

Autor: Devon M. Fitzgerald, David C. Grainger, Joseph T. Wade, Navjot Singh, Richard P. Bonocora, Shivani S. Singh

Publikováno v: Genes & Development. 28:214-219

Widespread intragenic transcription initiation has been observed in many species. Here we show that the Escherichia coli ehxCABD operon contains numerous intragenic promoters in both sense and antisense orientations. Transcription from these promoter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1451efa528aa0338662e1852540c9b
https://doi.org/10.1101/gad.234336.113

Properties of the Mechanosensitive Channel MscS Pore Revealed by Tryptophan Scanning Mutagenesis

Autor: Michelle D. Edwards, Heloisa Galbiati, Tim Rasmussen, Ian R. Booth, Samantha Miller, Shivani S. Singh, Akiko Rasmussen

Publikováno v: Biochemistry

Bacterial mechanosensitive channels gate when the transmembrane turgor rises to levels that compromise the structural integrity of the cell wall. Gating creates a transient large diameter pore that allows hydrated solutes to pass from the cytoplasm a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f73173e6952e8635239f415be1e77a
https://pubmed.ncbi.nlm.nih.gov/26126964

Lung Allograft Dysbiosis Associates with Immune Response and Primary Graft Dysfunction.

Autor: Nelson NC; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: nathaniel.nelson@nyulangone.org., Wong KK; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: kendrew.wong@nyulangone.org., Mahoney IJ; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: ian.mahoney@nyulangone.org., Malik T; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: tahir.malik@nyulangone.org., Rudym D; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. Electronic address: darya.rudym@nyulangone.org., Lesko MB; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. Electronic address: melissa.lesko@nyulangone.org., Qayum S; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. Electronic address: seema.qayum@nyulangone.org., Lewis TC; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. Electronic address: tyler.lewis@nyulangone.org., Chang SH; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA; Department of Cardiothoracic Surgery, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: stephanie.chang@nyulangone.org., Chan JCY; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA; Department of Cardiothoracic Surgery, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: justin.chan2@nyulangone.org., Geraci TC; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA; Department of Cardiothoracic Surgery, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: travis.geraci@nyulangone.org., Li Y; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: yonghua.li@nyulangone.org., Pamar P; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: prernapamar@utexas.edu., Schnier J; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: joseph.schnier@nyulangone.org., Singh R; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: rajbir.singh@nyulangone.org., Collazo D; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: destiny.collazo@nyulangone.org., Chang M; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: miao.chang@nyulangone.org., Kyeremateng Y; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: yaa.kyeremateng@nyulangone.org., McCormick C; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: colin.mccormick@nyulangone.org., Borghi S; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: sara.borghi@nyulangone.org., Patel S; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: sp6857@nyu.edu., Darawshi F; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; The Institute of Pulmonology, Hadassah Medical Center, Jerusalem, Israel; The Faculty of Medicine at the Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: fares.darawshi@nyulangone.org., Barnett CR; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: clea.barnett@nyulangone.org., Sulaiman I; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland. Electronic address: sheikmohammadimran.sulaiman@nyulangone.org., Kugler MC; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: matthias.kugler@nyulangone.org., Brosnahan SB; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: shari.brosnahan@nyulangone.org., Singh S; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: shivani.singh@nyulangone.org., Tsay JJ; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; VA New York Harbor Healthcare System, New York, NY, USA. Electronic address: jun-chieh.tsay@nyulangone.org., Wu BG; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; VA New York Harbor Healthcare System, New York, NY, USA. Electronic address: benjamin.wu@nyulangone.org., Pass HI; Department of Cardiothoracic Surgery, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: harvey.pass@nyulangone.org., Angel LF; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. Electronic address: luis.angel@nyulangone.org., Segal LN; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: leopoldo.segal@nyulangone.org., Natalini JG; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA; NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. Electronic address: jake.natalini@nyulangone.org.

Publikováno v: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2024 Nov 17. Date of Electronic Publication: 2024 Nov 17.