Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shivani, Sachdev"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Ligand-induced activation of G protein-coupled receptors (GPCRs) can initiate signaling through multiple distinct pathways with differing biological and physiological outcomes. There is intense interest in understanding how variation in GPCR
Externí odkaz:
https://doaj.org/article/4a42a0eb73b048879f76819876dd52f7
Autor:
Sam R. J. Hoare, Paul H. Tewson, Shivani Sachdev, Mark Connor, Thomas E. Hughes, Anne Marie Quinn
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Neurons integrate inputs over different time and space scales. Fast excitatory synapses at boutons (ms and μm), and slow modulation over entire dendritic arbors (seconds and mm) are all ultimately combined to produce behavior. Understanding the timi
Externí odkaz:
https://doaj.org/article/52579c6643d047b1bcac5a0da7a49c89
Autor:
Shivani Sachdev, Samuel D. Banister, Marina Santiago, Chris Bladen, Michael Kassiou, Mark Connor
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Synthetic cannabinoid receptor agonists (SCRAs) are new psychoactive substances associated with acute intoxication and even death. However, the molecular mechanisms through which SCRAs may exert their toxic effects remain unclear—including
Externí odkaz:
https://doaj.org/article/f0169851f2814f0abf981ce1dee90fed
Publikováno v:
ACS Chemical Biology. 17:2296-2303
Peptide epitope tags offer a valuable means for detection and manipulation of protein targets for which high quality detection reagents are not available. Most commonly used epitope tags are bound by conventional, full-size antibodies (Abs). The comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9b889b665bf700b7f4068967fe498f
https://doi.org/10.1021/acschembio.2c00407
https://doi.org/10.1021/acschembio.2c00407
Publikováno v:
PeerJ, Vol 7, p e7733 (2019)
Background Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have been sporadic reports of co-consumption of illicit drugs with rodenticides such as warfarin and brodifacoum (BFC)
Externí odkaz:
https://doaj.org/article/1dc1ea607d5747fcb8b0d1ae3179ae4b
Publikováno v:
Psychological Trauma: Theory, Research, Practice, and Policy.
The COVID-19 pandemic is a collective trauma causing profound psychological distress and, in some cases, positive psychological changes. The present study ascertained the most influential symptoms and strong connections between posttraumatic stress (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7d4a2049e5c42047078c231ea3e641
https://doi.org/10.1037/tra0001411
https://doi.org/10.1037/tra0001411
Publikováno v:
Bioconjugate chemistry. 33(10)
Synthetic molecules that form a covalent bond upon binding to a targeted biomolecule (proximity-induced reactivity) are the subject of intense biomedical interest for the unique pharmacological properties imparted by irreversible binding. However, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2649caffd1eddc3556631bfabb348247
https://pubmed.ncbi.nlm.nih.gov/36107739
https://pubmed.ncbi.nlm.nih.gov/36107739
Publikováno v:
Methods Cell Biol
Proper function of receptors on the cell surface is essential for homeostasis. Compounds that target cell surface receptors to address dysregulation have proven exceptionally successful as therapeutic agents; however, the development of compounds wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e2bb24e3fecdca927bc6f8b71e7ed9
https://doi.org/10.1016/bs.mcb.2021.06.004
https://doi.org/10.1016/bs.mcb.2021.06.004
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608838
Quantitative measurement of receptor signaling by different ligands is important for understanding the mechanism of drug action and screening of drugs. Here, we describe a simple and cost-effective method of measuring adenylyl cyclase inhibition, one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41bd67ed8b941264abff5aad7ccdcbd5
https://doi.org/10.1007/978-1-0716-0884-5_11
https://doi.org/10.1007/978-1-0716-0884-5_11
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2201
Quantitative measurement of receptor signaling by different ligands is important for understanding the mechanism of drug action and screening of drugs. Here, we describe a simple and cost-effective method of measuring adenylyl cyclase inhibition, one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a9dab635dbfbafed666abd485955af0
https://pubmed.ncbi.nlm.nih.gov/32975794
https://pubmed.ncbi.nlm.nih.gov/32975794