Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shivana M. Lightman"'
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Durable humoral immunity is dependent upon the generation of antigen-specific antibody titers, produced by non-proliferating bone marrow resident long-lived plasma cells (LLPC). Longevity is the hallmark of LLPC, but why and how they survive and func
Externí odkaz:
https://doaj.org/article/7ec6c308040a41828b8d61c398e70a92
Autor:
Guanxi Qiao, Scott H. Olejniczak, Kelly L. Singel, Tiffany R. Emmons, Elizabeth A. Repasky, Shivana M. Lightman, Shengqi Hou, Kelvin P. Lee, Andrew N. Lane, Thejaswini Giridharan, Brahm H. Segal, James Cm, Sharda Ap, Fan Twm, Holling Ga, Higashi Rm, Honikel Mm, Kevin H. Eng, Andrew M. Intlekofer
CD8 T cell activation prompts extensive transcriptome remodeling underlying effector differentiation and function. Regulation of transcriptome composition by the mitogen-inducible nuclear cap-binding complex (CBC) adaptor protein ARS2 has critical ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::855f8c17b2a7161a84638defcaea5066
https://doi.org/10.1101/2021.05.07.442963
https://doi.org/10.1101/2021.05.07.442963
Autor:
Shivana M. Lightman, G. Aaron Holling, Colin A. Chavel, Louise Carlson, Jennifer L. Peresie, Michael J. Nemeth, Scott H. Olejniczak, Kelvin P. Lee
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d61f21a4421db315ff06858f95f2e78
https://doi.org/10.2139/ssrn.3707280
https://doi.org/10.2139/ssrn.3707280
Autor:
Kelvin P. Lee, G. Aaron Holling, Scott H. Olejniczak, Shivana M. Lightman, Louise M. Carlson, Mackenzie M. Honikel, Jennifer Peresie, Colin Chavel, Michael J. Nemeth
Publikováno v:
Immunity
Humoral immunity is essential for protection against pathogens, emphasized by the prevention of 2-3 million deaths worldwide annually by childhood immunizations. Long-term protective immunity is dependent on the continual production of neutralizing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c3d978aa1a09543b9c2855d3f1c3dc
https://doi.org/10.1016/j.immuni.2021.10.005
https://doi.org/10.1016/j.immuni.2021.10.005
Autor:
Martha S. Jordan, Catherine M. Gavile, G. Aaron Holling, Adam Utley, Wensheng Liu, Taku Kambayashi, Megan Murray-Dupuis, Lawrence H. Boise, James R. Cooper, Kelvin P. Lee, Cheryl H Rozanski, Colin Chavel, Benjamin G. Barwick, Orla Maguire, Peng Peng, Scott H. Olejniczak, Shivana M. Lightman
Publikováno v:
Cell reports
SUMMARY Durable humoral immunity against epidemic infectious disease requires the survival of long-lived plasma cells (LLPCs). LLPC longevity is dependent on metabolic programs distinct from short-lived plasma cells (SLPCs); however, the mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0039689922f85b0fcbee617551def42e
https://pubmed.ncbi.nlm.nih.gov/32579940
https://pubmed.ncbi.nlm.nih.gov/32579940
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Durable humoral immunity is dependent upon the generation of antigen-specific antibody titers, produced by non-proliferating bone marrow resident long-lived plasma cells (LLPC). Longevity is the hallmark of LLPC, but why and how they survive and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1b6f525909490f057bb9a24787abbe
https://doi.org/10.3389/fimmu.2019.00965
https://doi.org/10.3389/fimmu.2019.00965
Publikováno v:
The Journal of Immunology. 204:71.8-71.8
Protective antibodies against diseases such as measles and polio primarily come from bone marrow (BM) resident long lived plasma cells (LLPC) and are a key component of durable humoral immunity. As LLPC are not innately long lived a major question re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80cd096f59306928f12d78b75c6262b6
https://doi.org/10.4049/jimmunol.204.supp.71.8
https://doi.org/10.4049/jimmunol.204.supp.71.8
Autor:
Spencer Rosario, Katerina I. Leonova, Kalyana Moparthy, Kelvin P. Lee, Andrei V. Gudkov, David W. Wolff, Aryn M. Rowsam, Anna Bianchi-Smiraglia, Mark D. Long, Eugene S. Kandel, P. Leif Bergsagel, Emily E. Fink, Hayley C. Affronti, Matthew V. Roll, Sudha Moparthy, Zhannan Han, Anthony Polechetti, Ilya Gitlin, Shivana M. Lightman, Dong Hyun Yun, Archis Bagati, Dominic J. Smiraglia, Brittany C. Lipchick, Mikhail A. Nikiforov
Publikováno v:
The Journal of clinical investigation. 128(10)
Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is the central transcriptional regulator of the xenobiotic response. Our study r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d990e088cba77cb1a625050ba8c4b11
https://pubmed.ncbi.nlm.nih.gov/30198903
https://pubmed.ncbi.nlm.nih.gov/30198903
Publikováno v:
The Journal of Immunology. 202:121.7-121.7
Long lived plasma cells (LLPC) are a key component of protective humoral immunity. The ability of these cells to maintain longevity and a durable antibody response is largely dependent on the complex nature of the bone marrow (BM) microenvironment in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31d450f2878ae96fe1157630b9e2420f
https://doi.org/10.4049/jimmunol.202.supp.121.7
https://doi.org/10.4049/jimmunol.202.supp.121.7
Autor:
Adam Utley, James J. M. Cooper, Colin A. Chavel, Peng Peng, Louise M. Carlson, Shivana M. Lightman, Taku Kambayashi, Jonathan Green, Kelvin P. Lee
Publikováno v:
The Journal of Immunology. 200:51.2-51.2
Durable humoral immunity depends upon bone marrow resident long-lived plasma cell (LLPC) survival. We have shown that CD28, the canonical T-cell costimulatory molecule, is required for LLPC survival; however, the mechanistic basis for this is unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b3df95d6075fcf3ef53a6644819bde9
https://doi.org/10.4049/jimmunol.200.supp.51.2
https://doi.org/10.4049/jimmunol.200.supp.51.2