Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shivan Chetty"'
Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The advances in cancer biology and pathogenesis during the past two decades, have resulted in immunotherapeutic strategies that have revolutionized the treatment of malignancies, from relatively non-selective toxic agents to specific, mechanism-based
Externí odkaz:
https://doaj.org/article/54212799318d4a71b57ceb8d733de5c7
Autor:
Tsungai Ivai Jongwe, Ros Chapman, Nicola Douglass, Shivan Chetty, Gerald Chege, Anna-Lise Williamson
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159141 (2016)
Over 90% of HIV/AIDS positive individuals in sub-Saharan Africa are infected with highly heterogeneous HIV-1 subtype C (HIV-1C) viruses. One of the best ways to reduce the burden of this disease is the development of an affordable and effective proph
Externí odkaz:
https://doaj.org/article/34b125d8170e419f98db2c34fe20938d
Autor:
Precious Hlongwane, Neelakshi Mungra, Suresh Madheswaran, Olusiji A. Akinrinmade, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 6, Iss 2, p 72 (2018)
Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or enzymes has been shown to promote the induction of apoptosis in cancerous
Externí odkaz:
https://doaj.org/article/cc54a3a76d5f43a58bf8257e0236ef27
Autor:
Sandra Jordaan, Olusiji A. Akinrinmade, Thomas Nachreiner, Christian Cremer, Krupa Naran, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 6, Iss 1, p 28 (2018)
Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic payloads to selectively eliminate tumor cells. This payload can be either a synthetic small molecule drug composing an antibody-drug conjugate (ADC) or a cytotoxic pro
Externí odkaz:
https://doaj.org/article/66c4f9f9103a4660be7438b5d9de26a3
Autor:
Mehmet Kemal Tur, Adebukola K. Daramola, Stefan Gattenlöhner, Marco Herling, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 4, p 59 (2017)
Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation
Externí odkaz:
https://doaj.org/article/c81239a63d3d4979ae3dade26808e59b
Autor:
Shivan Chetty, Pamla Govender, Jennifer Zupkosky, Mona Pillay, Musie Ghebremichael, Mahomed-Yunus S Moosa, Thumbi Ndung'u, Filippos Porichis, Victoria O Kasprowicz
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118654 (2015)
The ability of antigen-specific T cells to simultaneously produce multiple cytokines is thought to correlate with the functional capacity and efficacy of T cells. These 'polyfunctional' T cells have been associated with control of HIV. We aimed to as
Externí odkaz:
https://doaj.org/article/cb61abca59ac489e8ce4f9e744ec9faf
Autor:
Olusiji A. Akinrinmade, Shivan Chetty, Adebukola K. Daramola, Mukit-ul Islam, Theo Thepen, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 3, p 56 (2017)
To date, no curative therapy is available for the treatment of most chronic inflammatory diseases such as atopic dermatitis, rheumatoid arthritis, or autoimmune disorders. Current treatments require a lifetime supply for patients to alleviate clinica
Externí odkaz:
https://doaj.org/article/2b062270a5b34f8fadcb49a87a9c3a1e
Autor:
Olusiji A. Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 3, p 36 (2017)
Some of the most promising small molecule toxins used to generate antibody drug conjugates (ADCs) include anti-mitotic agents (e.g., auristatin and its derivatives) which are designed to attack cancerous cells at their most vulnerable state during mi
Externí odkaz:
https://doaj.org/article/b58b69018c914f209e1a2ad9b38d89fb
Autor:
Anna Bochicchio, Sandra Jordaan, Valeria Losasso, Shivan Chetty, Rodrigo Casasnovas Perera, Emiliano Ippoliti, Stefan Barth, Paolo Carloni
Publikováno v:
Biomedicines, Vol 5, Iss 1, p 9 (2017)
Targeted human cytolytic fusion proteins (hCFPs) are humanized immunotoxins for selective treatment of different diseases including cancer. They are composed of a ligand specifically binding to target cells genetically linked to a human apoptosis-ind
Externí odkaz:
https://doaj.org/article/84a6e6881deb49c7ace63c399f423782
Autor:
Jessica E Mitchell, Shivan Chetty, Pamla Govender, Mona Pillay, Manjeetha Jaggernath, Anne Kasmar, Thumbi Ndung'u, Paul Klenerman, Bruce D Walker, Victoria O Kasprowicz
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37920 (2012)
Monitoring of latent Mycobacterium tuberculosis infection may prevent disease. We tested an ESAT-6 and CFP-10-specific IFN-γ Elispot assay (RD1-Elispot) on 163 HIV-infected individuals living in a TB-endemic setting. An RD1-Elispot was performed eve
Externí odkaz:
https://doaj.org/article/124b52dcfd474dcebf7e1d0e50590a7b