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Akademický článek

Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

Autor: Shivam Vora, Ariel Andrew, Ramyashree Prasanna Kumar, Deborah Nazareth, Alexis Bonfim-Melo, Yoon Lim, Xin Yee Ong, Madushan Fernando, Yaowu He, John D. Hooper, Nigel AJ McMillan, Jelena Urosevic, Jon Travers, Jamal Saeh, Sharad Kumar, Mathew JK Jones, Brian Gabrielli

Publikováno v: Cell Death and Disease, Vol 15, Iss 11, Pp 1-9 (2024)

Abstract Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human papilloma virus (HPV) oncogenes and loss of retinoblastoma (RB) protein function has

Externí odkaz: https://doaj.org/article/3d015f58b83e447f8885ff4062e043e7

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Akademický článek

Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

Autor: Madushan Fernando, Pascal H. G. Duijf, Martina Proctor, Alexander J. Stevenson, Anna Ehmann, Shivam Vora, Dubravka Skalamera, Mark Adams, Brian Gabrielli

Publikováno v: Oncogenesis, Vol 10, Iss 5, Pp 1-11 (2021)

Abstract Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations. DNA

Externí odkaz: https://doaj.org/article/1232e95c12aa4baf83e1909df39172e3

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Identification of Crime-Prone Areas Using Data Mining Techniques

Autor: Jainam Rambhia, Bhoomika Valani, Shivam Vora, Chaitanya Kumbar, Neha Katre

Publikováno v: Practical Data Mining Techniques and Applications ISBN: 9781003390220

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0f31c81e9fc8307825a92593251daae
https://doi.org/10.1201/9781003390220-10

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Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

Autor: Martina Proctor, Mark N. Adams, Alexander J. Stevenson, Brian Gabrielli, Madushan Fernando, Anna Ehmann, Shivam Vora, Dubravka Skalamera, Pascal H.G. Duijf

Publikováno v: Oncogenesis, Vol 10, Iss 5, Pp 1-11 (2021)
Oncogenesis

Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations. DNA damage tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55c447f52915df53a2118004ae48b13
https://doi.org/10.1038/s41389-021-00329-8

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