Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Shivalingappa K. Swamynathan"'
Autor:
Shivalingappa K. Swamynathan
Publikováno v:
Journal of Ophthalmology, Vol 2013 (2013)
The ocular surface—a continuous epithelial surface with regional specializations including the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian glands connected by the overlying tear film—plays a central role
Externí odkaz:
https://doaj.org/article/c699bfaa59854aab87cb4098ca04ffcc
Publikováno v:
Differentiation.
PurposeEnvironmentally-triggered dry eye disease (DED) or keratoconjunctivitis sicca (KCS), which constitutes the majority of DED cases, currently is palliatively treated with aqueous replacement solutions that do not target the dysfunction of the mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cded2fc9a74d54cc1051a3234632385
https://doi.org/10.1101/2022.12.07.519513
https://doi.org/10.1101/2022.12.07.519513
Publikováno v:
Biochem Biophys Res Commun
The secreted Ly-6/uPAR related protein-1 (SLURP1) is an anti-angiogenic and anti-inflammatory peptide highly expressed by the mucosal epithelial cells. SLURP1 is abundantly expressed by the corneal epithelial cells and is significantly downregulated
Publikováno v:
Ocul Surf
PURPOSE: Previously we demonstrated that the secreted Ly-6/uPAR related protein-1 (SLURP1), abundantly expressed in the corneal epithelium (CE) and secreted into the tear fluid, serves as an anti-inflammatory and anti-angiogenic molecule. Here we des
Autor:
Paul R. Kinchington, Anil Tiwari, Shenghe Tian, John Gnalian, Sudha Swamynathan, Nicholas Alexander, Shivalingappa K. Swamynathan
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Kruppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and development, and if dysregulated, it induces epithelial-mesenchymal tran
Apicobasal polarity (ABP) is an important feature of many epithelial cells, including those in the stratified squamous corneal epithelium (CE). Previously, we demonstrated that KLF4 promotes CE homeostasis by suppressing epithelial-mesenchymal transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd57b4255e8b0191516f79e8944e703
https://doi.org/10.1101/2020.01.08.899385
https://doi.org/10.1101/2020.01.08.899385
Autor:
Doreswamy Kenchegowda, Stephen A K Harvey, Sudha Swamynathan, Kira L Lathrop, Shivalingappa K Swamynathan
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44771 (2012)
Klf5 plays an important role in maturation and maintenance of the mouse ocular surface. Here, we quantify WT and Klf5-conditional null (Klf5CN) corneal gene expression, identify Klf5-target genes and compare them with the previously identified Klf4-t
Externí odkaz:
https://doaj.org/article/d58c68a85e6e46569891c0a215667e2f
Publikováno v:
Ocul Surf
Conjunctival goblet cells (CGCs) are specialized cells that produce and secrete soluble mucins to the tear film that bathes the ocular surface. CGC numbers and functions are affected in various ocular surface diseases including dry eye disease with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab749075150ccd4e4cd87647546f0bc
https://europepmc.org/articles/PMC7004882/
https://europepmc.org/articles/PMC7004882/
Autor:
Sudha Swamynathan, Vishal Jhanji, Nicholas Alexander, Anil Tiwari, Shivalingappa K. Swamynathan, Chelsea L. Loughner, John Gnalian
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human u