Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Shivalingappa K Swamynathan"'
Autor:
Doreswamy Kenchegowda, Stephen A K Harvey, Sudha Swamynathan, Kira L Lathrop, Shivalingappa K Swamynathan
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44771 (2012)
Klf5 plays an important role in maturation and maintenance of the mouse ocular surface. Here, we quantify WT and Klf5-conditional null (Klf5CN) corneal gene expression, identify Klf5-target genes and compare them with the previously identified Klf4-t
Externí odkaz:
https://doaj.org/article/d58c68a85e6e46569891c0a215667e2f
Publikováno v:
Differentiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb0714ff216e15ac38dc7eb085c01ab
https://doi.org/10.1016/j.diff.2023.02.002
https://doi.org/10.1016/j.diff.2023.02.002
PurposeEnvironmentally-triggered dry eye disease (DED) or keratoconjunctivitis sicca (KCS), which constitutes the majority of DED cases, currently is palliatively treated with aqueous replacement solutions that do not target the dysfunction of the mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cded2fc9a74d54cc1051a3234632385
https://doi.org/10.1101/2022.12.07.519513
https://doi.org/10.1101/2022.12.07.519513
Publikováno v:
Ocul Surf
PURPOSE: Previously we demonstrated that the secreted Ly-6/uPAR related protein-1 (SLURP1), abundantly expressed in the corneal epithelium (CE) and secreted into the tear fluid, serves as an anti-inflammatory and anti-angiogenic molecule. Here we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b143b0e4575934fd3c3a91edbe64ff
https://pubmed.ncbi.nlm.nih.gov/34923162
https://pubmed.ncbi.nlm.nih.gov/34923162
Publikováno v:
Biochem Biophys Res Commun
The secreted Ly-6/uPAR related protein-1 (SLURP1) is an anti-angiogenic and anti-inflammatory peptide highly expressed by the mucosal epithelial cells. SLURP1 is abundantly expressed by the corneal epithelial cells and is significantly downregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763ee85bf8e957c428353a2c9bf33cb4
https://doi.org/10.1016/j.bbrc.2019.07.123
https://doi.org/10.1016/j.bbrc.2019.07.123
Autor:
Paul R. Kinchington, Anil Tiwari, Shenghe Tian, John Gnalian, Sudha Swamynathan, Nicholas Alexander, Shivalingappa K. Swamynathan
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Kruppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and development, and if dysregulated, it induces epithelial-mesenchymal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a2bff4d970a10d77dddafbcb4becf8
http://europepmc.org/articles/PMC6383833
http://europepmc.org/articles/PMC6383833
Apicobasal polarity (ABP) is an important feature of many epithelial cells, including those in the stratified squamous corneal epithelium (CE). Previously, we demonstrated that KLF4 promotes CE homeostasis by suppressing epithelial-mesenchymal transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd57b4255e8b0191516f79e8944e703
https://doi.org/10.1101/2020.01.08.899385
https://doi.org/10.1101/2020.01.08.899385
Publikováno v:
Ocul Surf
Conjunctival goblet cells (CGCs) are specialized cells that produce and secrete soluble mucins to the tear film that bathes the ocular surface. CGC numbers and functions are affected in various ocular surface diseases including dry eye disease with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab749075150ccd4e4cd87647546f0bc
https://europepmc.org/articles/PMC7004882/
https://europepmc.org/articles/PMC7004882/
Autor:
Sudha Swamynathan, Shivalingappa K. Swamynathan, Gregory Campbell, Anil Tiwari, Vishal Jhanji
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Proper balance between cell proliferation and differentiation is essential for corneal epithelial (CE) stratification and homeostasis. Although bone morphogenetic protein-6 (BMP6) is known to be expressed in the CE for over 25 years, its func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e3196f3910ba7379bd17692150885f
https://doi.org/10.1167/iovs.61.10.46
https://doi.org/10.1167/iovs.61.10.46
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Previously, we demonstrated that Kruppel-like factor 4 (KLF4) promotes corneal epithelial (CE) homeostasis by suppressing epithelial-mesenchymal transition (EMT) and TGF-β signaling. As TGF-β affects epithelial apicobasal polarity (ABP) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a8c8eb8465fdaebd45323a30132fe9
https://doi.org/10.1167/iovs.61.5.15
https://doi.org/10.1167/iovs.61.5.15