Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Shivakumar Subbanna"'
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1296 (2024)
Cannabis sativa is known for producing over 120 distinct phytocannabinoids, with Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) being the most prominent, primarily in their acidic forms. Beyond Δ9-THC and CBD, a wide array of lesser-known
Externí odkaz:
https://doaj.org/article/0e215ecfa13c4dd6aa92975bd5a50095
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholi
Externí odkaz:
https://doaj.org/article/435994d00b734e18a90ea82931cd1bac
Autor:
Mariko Saito, Shivakumar Subbanna, Xiuli Zhang, Stefanie Canals-Baker, John F. Smiley, Donald A. Wilson, Bhaskar C. Das
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Ethanol exposure in neonatal mice induces acute neurodegeneration followed by long-lasting glial activation and GABAergic cell deficits along with behavioral abnormalities, providing a third trimester model of fetal alcohol spectrum disorders (FASD).
Externí odkaz:
https://doaj.org/article/66f6ef13dcbc424e839d900254987a98
Publikováno v:
Cells, Vol 12, Iss 3, p 442 (2023)
The brain’s ability to strengthen or weaken synaptic connections is often termed synaptic plasticity. It has been shown to function in brain remodeling following different types of brain damage (e.g., drugs of abuse, alcohol use disorders, neurodeg
Externí odkaz:
https://doaj.org/article/9c74294e6d7640a3bf8e7497962f150e
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1560 (2022)
The actions of cannabis are mediated by G protein-coupled receptors that are part of an endogenous cannabinoid system (ECS). ECS consists of the naturally occurring ligands N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), the
Externí odkaz:
https://doaj.org/article/768dc98acd8b4b95b97cde15e5fabdc2
Publikováno v:
Brain Sciences, Vol 12, Iss 6, p 793 (2022)
An embryo’s in-utero exposure to ethanol due to a mother’s alcohol drinking results in a range of deficits in the child that are collectively termed fetal alcohol spectrum disorders (FASDs). Prenatal ethanol exposure is one of the leading causes
Externí odkaz:
https://doaj.org/article/8295e3e084dc40269305a8d00a82a5ea
Publikováno v:
Brain Sciences, Vol 10, Iss 5, p 271 (2020)
Alcohol consumption by pregnant women may produce neurological abnormalities that affect cognitive processes in children and are together defined as fetal alcohol spectrum disorders (FASDs). However, the molecular underpinnings are still poorly defin
Externí odkaz:
https://doaj.org/article/9e82564cf6614270aa995f3233983ddd
Autor:
Shivakumar Subbanna, Nagaraja N. Nagre, Madhu Shivakumar, Vikram Joshi, Delphine Psychoyos, Abdullah Kutlar, Nagavedi S. Umapathy, Balapal S. Basavarajappa
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Alcohol exposure can affect brain development, leading to long-lasting behavioral problems, including cognitive impairment, which together is defined as fetal alcohol spectrum disorder (FASD). However, the fundamental mechanisms through which this oc
Externí odkaz:
https://doaj.org/article/2b836bb88a3042429bf1e3132d20c5ba
Publikováno v:
Brain Sciences, Vol 9, Iss 1, p 14 (2019)
The chief psychoactive constituent of many bioactive phytocannabinoids (Δ9-tetrahydrocannabinol, Δ9-THC) found in hemp, cannabis or marijuana plants are scientifically denoted by the Latin term, Cannabis sativa, acts on cell surface receptors. Thes
Externí odkaz:
https://doaj.org/article/d6ea98c9d5ae47e8a722bb237ea73775
Autor:
Shivakumar Subbanna, Madhu Shivakumar, Nagavedi S. Umapathy, Mariko Saito, Panaiyur S. Mohan, Asok Kumar, Ralph A. Nixon, Alexander D. Verin, Delphine Psychoyos, Balapal S. Basavarajappa
Publikováno v:
Neurobiology of Disease, Vol 54, Iss , Pp 475-485 (2013)
Rodent exposure to binge-like ethanol during postnatal day 7 (P7), which is comparable to the third trimester of human pregnancy, induces neuronal cell loss. However, the molecular mechanisms underlying these neuronal losses are still poorly understo
Externí odkaz:
https://doaj.org/article/0cf56506ca7547cd8cfc143540712148