Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shivaji A. Thadke"'
Autor:
Shivaji A. Thadke, Bijoyananda Mishra, Maidul Islam, Sandip Pasari, Sujit Manmode, Boddu Venkateswara Rao, Mahesh Neralkar, Ganesh P. Shinde, Gulab Walke, Srinivas Hotha
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Arabinogalactan forms parts of the cellular envelope ofMycobacterium tuberculosis, however due to its size chemical synthesis is a massive task. Here the authors report the synthesis of branched heneicosafuranosyl arabinogalactan fragment by repeated
Externí odkaz:
https://doaj.org/article/69a72a0f157644d2b14b02268b36adc4
Publikováno v:
The Journal of organic chemistry. 87(21)
Gamma peptide nucleic acids (PNAs) are a promising class of nucleic acid mimics that adopt either a right- or left-handed helical motif as individual strands and hybridize to DNA or RNA with high affinity and sequence specificity, or not at all, depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8347829a1243f14a77aec640a55f280
https://pubmed.ncbi.nlm.nih.gov/36190146
https://pubmed.ncbi.nlm.nih.gov/36190146
Publikováno v:
BiopolymersREFERENCES. 112(11)
Peptide nucleic acids (PNAs) have primarily been used to achieve therapeutic gene modulation through antisense strategies since their design in the 1990s. However, the application of PNAs as a functional nanomaterial has been more recent. We recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b08de07be99d1fc25d171f3ae2d8ef
https://pubmed.ncbi.nlm.nih.gov/34214178
https://pubmed.ncbi.nlm.nih.gov/34214178
Publikováno v:
The Journal of Organic Chemistry. 84:1276-1287
A robust synthetic route has been developed for preparing optically pure, Fmoc-protected diethylene glycol-containing (R)- and (S)-γPNA monomers. The strategy involves the application of 9-(4-bromophenyl)-9-fluorenyl as a temporary, safety-catch pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9abf2590e776be21d1c58386e669b91
https://doi.org/10.1021/acs.joc.8b02714
https://doi.org/10.1021/acs.joc.8b02714
Autor:
Gordon S. Rule, Roberto R. Gil, Kirti Bhatt, Wei-Che Hsieh, Charles A. Thornton, Arnab Mukherjee, Mengshen'David' Chen, Ashif Y. Shaikh, Shivaji A. Thadke, Chakicherla Gayathri, Danith H. Ly, V. M. Hridya, J. Dinithi R. Perera
Publikováno v:
Biochemistry. 57:2094-2108
We report the development of a new class of nucleic acid ligands that is comprised of Janus bases and the MPγPNA backbone and is capable of binding rCAG repeats in a sequence-specific and selective manner via, inference, bivalent H-bonding interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47f3a38f3915b8a2a5b8c643afdcdf9
https://doi.org/10.1021/acs.biochem.8b00062
https://doi.org/10.1021/acs.biochem.8b00062
Autor:
Wei-Che Hsieh, Arunava Manna, Danith H. Ly, Shivaji A. Thadke, Gopalsamy Sureshkumar, Raman Bahal
Publikováno v:
Chembiochem
Template-directed synthesis offers several distinct benefits over conventional laboratory creation, including unsurpassed reaction rate and selectivity. Although it is central to many biological processes, such an approach has rarely been applied to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436b9551ce1fc4d83896525b38f09faa
https://doi.org/10.1002/cbic.201700574
https://doi.org/10.1002/cbic.201700574
Autor:
Danith H. Ly, Shivaji A. Thadke, Wei-Che Hsieh, Raman Bahal, Krzysztof Sobczak, Charles A. Thornton, Kirti Bhatt
Publikováno v:
Biochemistry. 57:907-911
Toxic RNAs containing expanded trinucleotide repeats are the cause of many neuromuscular disorders, one being myotonic dystrophy type 1 (DM1). DM1 is triggered by CTG-repeat expansion in the 3′-untranslated region of the DMPK gene, resulting in a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105751f9a5881986c1002c20b27432cc
https://doi.org/10.1021/acs.biochem.7b01239
https://doi.org/10.1021/acs.biochem.7b01239
Autor:
Srinivas Hotha, Sandip Pasari, Mahesh Neralkar, Gulab Walke, Shivaji A. Thadke, Sujit Manmode, Ganesh P Shinde, Boddu Venkateswara Rao, Maidul Islam, Bijoyananda Mishra
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Emergence of multidrug-resistant and extreme-drug-resistant strains of Mycobacterium tuberculosis (MTb) can cause serious socioeconomic burdens. Arabinogalactan present on the cellular envelope of MTb is unique and is required for its survival; acces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498d162d786e6b57186b2a1c416dac85
https://doi.org/10.1038/ncomms14019
https://doi.org/10.1038/ncomms14019
Autor:
Srinivas Hotha, Shivaji A. Thadke
Publikováno v:
Org. Biomol. Chem.. 12:9914-9920
Complex oligosaccharide syntheses employ the use of more than one glycosyl donor and hence, methods for the interconversion of glycosyl donors are highly valuable for the overall synthesis plan. Herein, n-pentenyl glycosides are efficiently converted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deec9ea190b2404c8119640de4acfcc
https://doi.org/10.1039/c4ob01395f
https://doi.org/10.1039/c4ob01395f
Publikováno v:
The Journal of Organic Chemistry. 79:7358-7371
Stereoselective synthesis of furanosides is still a daunting task, unlike the pyranosides, for which several methods exist. Herein, a unified stereoselective strategy for the synthesis of 1,2-trans and 1,2-cis furanosides is revealed for seven out of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222bba141af11051207102a351456372
https://doi.org/10.1021/jo501052y
https://doi.org/10.1021/jo501052y