Výsledky vyhledávání - "Shivai Gupta"

Epitope Mapping of Pathogenic Autoantigens on Sjögren’s Syndrome-Susceptible Human Leukocyte Antigens Using In Silico Techniques

Autor: Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen

Publikováno v: Journal of Clinical Medicine; Volume 11; Issue 6; Pages: 1690

Sjögren’s syndrome (SjS) is characterized by lymphocytic infiltration and the dysfunction of the salivary and lacrimal glands. The autoimmune response is driven by the effector T cells and their cytokines. The activation of the effector helper T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4664f46dcd61438c4dc3bc2918b1927e

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Blocking IAg

Autor: Shivai, Gupta, Danmeng, Li, David A, Ostrov, Cuong Q, Nguyen

Publikováno v: Life Sci

BACKGROUND: Sjögren’s syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa8d171a5cb2142b2beef50c9568d0f8
https://pubmed.ncbi.nlm.nih.gov/34843735

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Single-Cell Sequencing of T cell Receptors: A Perspective on the Technological Development and Translational Application

Autor: Cuong Q. Nguyen, Shivai Gupta, Touyana Semenova, Alexandria Voigt, Richard Witas

Publikováno v: Adv Exp Med Biol
Advances in Experimental Medicine and Biology ISBN: 9789811544934

T cells recognize peptides bound to major histocompatibility complex (MHC) class I and class II molecules at the cell surface. This recognition is accomplished by the expression of T cell receptors (TCR) which are required to be diverse and adaptable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4301dd59a0a1eaeb3827b5439b0378d3
https://pubmed.ncbi.nlm.nih.gov/32949388

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Blocking I Ag7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice

Autor: Cuong Q. Nguyen, Danmeng Li, Shivai Gupta, David A. Ostrov

Publikováno v: Life Sciences. 288:120182

Background Sjogren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc2c931fad6f95530588c90990ad3178
https://doi.org/10.1016/j.lfs.2021.120182

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Disease-specific antigen presentation on MHC class II is inhibited by a small molecule in Sjögren’s Syndrome

Autor: Shivai Gupta, Cuong Q Nguyen

Publikováno v: The Journal of Immunology. 206:104.01-104.01

Sjogren’s Syndrome (SjS) is one of the more common autoimmune diseases that has a strong genetic linkage. To date, no vaccine or therapeutic exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Class II MHC are the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::702452c2d53236fdbea0fde31582a679
https://doi.org/10.4049/jimmunol.206.supp.104.01

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Contributions of Major Cell Populations to Sjögren’s Syndrome

Autor: Richard Witas, Cuong Q. Nguyen, Shivai Gupta

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 9, Iss 3057, p 3057 (2020)

Sjögren’s syndrome (SS) is a female dominated autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal glands and subsequent exocrine glandular dysfunction. SS also may exhibit a broad array of extraglandular manifes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df54385a1572df9b8a60eada67c50896
https://doi.org/10.3390/jcm9093057

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