Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shiva Krishna Reddy Guduru"'
Autor:
Srinivas Chamakuri, Sunny Ann Tang, Kevin A. Tran, Shiva Krishna Reddy Guduru, Peter K. Bolin, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Molecules, Vol 27, Iss 11, p 3419 (2022)
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five
Externí odkaz:
https://doaj.org/article/e03a14a45cc14395a67b86b6084b9499
Autor:
Justin M. Rectenwald, Shiva Krishna Reddy Guduru, Zhao Dang, Leonard B. Collins, Yi-En Liao, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kyle W. Kaufmann, Scott M. Hammond, Dmitri B. Kireev, Stephen V. Frye, Kenneth H. Pearce
Publikováno v:
Molecules, Vol 25, Iss 4, p 979 (2020)
Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails. These marks serve as recruitment sites for ot
Externí odkaz:
https://doaj.org/article/befc2b9a6ae44e7dbdde672ada128d9b
Autor:
Emily R. Mason, Timothy M. Willson, Michael A. Stashko, Ivie L. Conlon, Kenneth H. Pearce, Brian Hardy, Charles Travis Moerk, Shaoyou Chu, Chizuru Kinoshita, Megan D. Hopkins, Frances Potjewyd, Jessica E. Young, Timothy E. Richardson, David A. Rogers, Shiva Krishna Reddy Guduru, Joel K. Annor-Gyamfi, Dmitri Kireev, Disha Soni, Stephen V. Frye, Xiaodong Wang, Carrow I. Wells, Jeffrey Aubé, Felix Nwogbo, Kevin J. Frankowski, Alison D. Axtman
IntroductionThe portfolio of novel targets to treat Alzheimer’s disease (AD) has been enriched by the AMP-AD program.MethodsA cheminformatics-driven effort enabled identification of existing small molecule modulators for many protein targets nomina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c99e07fe7252807651f172faca5abac
https://doi.org/10.1101/2021.07.22.453404
https://doi.org/10.1101/2021.07.22.453404
Autor:
Navneet K Venugopal, Matthew V. Holt, Bethany C Taylor, Conrad Santini, James C. Campbell, Damian W. Young, Prashi Jain, Idris O. Raji, Shiva Krishna Reddy Guduru, Steven Liu, Errol L.G. Samuel, Kevin Tran, Prasanna Kandel, Lyra Chang, Kevin R. MacKenzie, Banumathi Sankaran, Nicolas L. Young, Michelle Nguyen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isolated UHRF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79af6afde76573cc34c5d34fb4a11975
https://doi.org/10.1038/s41598-020-80588-4
https://doi.org/10.1038/s41598-020-80588-4
Autor:
Shiva Krishna Reddy Guduru, Kevin R. MacKenzie, Srinivas Chamakuri, Conrad Santini, Damian W. Young, Idris O. Raji
Publikováno v:
The Journal of Organic Chemistry. 83:11777-11793
The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized. Using an efficient six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a946589632b71cf1a85b42dfdc8b6d77
https://doi.org/10.1021/acs.joc.8b01708
https://doi.org/10.1021/acs.joc.8b01708
Autor:
J. Winston Arney, Prashi Jain, Kevin R. MacKenzie, Damian W. Young, Conrad Santini, Srinivas Chamakuri, Shiva Krishna Reddy Guduru
Publikováno v:
The Journal of Organic Chemistry. 83:6541-6555
The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized. Using an efficient fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95472062892bfea9ba94e59f2dc9745b
https://doi.org/10.1021/acs.joc.8b00854
https://doi.org/10.1021/acs.joc.8b00854
Publikováno v:
MedChemComm. 9:27-43
Over the years, rapamycin has attracted serious attention due to its remarkable biological properties and as a potent inhibitor of the mammalian target of rapamycin (mTOR) protein through its binding with FKBP-12. Several efficient strategies that ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2b891279ee1c53e04cf587eae492bc
https://doi.org/10.1039/c7md00474e
https://doi.org/10.1039/c7md00474e
Autor:
Jacqueline Norris-Drouin, Leonard B. Collins, Justin M. Rectenwald, Scott M. Hammond, Shiva Krishna Reddy Guduru, Stephen V. Frye, Kenneth H. Pearce, Kyle W Kaufmann, Dmitri Kireev, Stephanie H. Cholensky, Yi-En Liao, Zhao Dang
Publikováno v:
Molecules, Vol 25, Iss 4, p 979 (2020)
Molecules
Molecules
Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails. These marks serve as recruitment sites for ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78c626502aed089d9af94acbb3fda34
https://doi.org/10.3390/molecules25040979
https://doi.org/10.3390/molecules25040979
Publikováno v:
Organic Letters. 17:468-471
A practical stereoselective synthesis to obtain the substituted furan ring as the substructure of eribulin is developed. An asymmetric syn-aldol and intramolecular oxy-Michael were two key steps in our approach. The functionalized furan derivatives w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6948e8f9f012ef55f3c8166cabfb719f
https://doi.org/10.1021/ol503464s
https://doi.org/10.1021/ol503464s
Publikováno v:
Organic Letters. 17:480-483
A stereoselective synthesis of a rapamycin fragment is developed and further utilized toward building a macrocyclic chemical toolbox. The amino alcohol moiety embedded in the 22-membered macrocyclic ring allowed for the addition of a variation in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5def6b6f5edb84c4ce86f4f164d8db43
https://doi.org/10.1021/ol5034833
https://doi.org/10.1021/ol5034833