Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Shiva K Tyagarajan"'
Publikováno v:
eLife, Vol 11 (2022)
Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein use
Externí odkaz:
https://doaj.org/article/e784d21959234feab30ac1625c083b70
Autor:
Claire de Groot, Amalia Floriou-Servou, Yuan-Chen Tsai, Simon Früh, Manuela Kohler, Georgia Parkin, Cornelia Schwerdel, Giovanna Bosshard, Kai Kaila, Jean-Marc Fritschy, Shiva K Tyagarajan
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007073 (2017)
In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic syna
Externí odkaz:
https://doaj.org/article/7cb2b632fcce41a0b646288801f9b475
Autor:
Mélissa Farinelli, Fabrice D Heitz, Benjamin F Grewe, Shiva K Tyagarajan, Fritjof Helmchen, Isabelle M Mansuy
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34047 (2012)
An imbalance between pro-survival and pro-death pathways in brain cells can lead to neuronal cell death and neurodegeneration. While such imbalance is known to be associated with alterations in glutamatergic and Ca(2+) signaling, the underlying mecha
Externí odkaz:
https://doaj.org/article/b1cf6a2140a14f388931394cd7d4dd31
Autor:
Myrto Andreadou, Florian Ingelfinger, Donatella De Feo, Ekaterina Friebel, Selma Tuzlak, Teresa M.L. Cramer, Bettina Schreiner, Pascale Eede, Shirin Schneeberger, Maria Geesdorf, Frederike Ridder, Christina Welsh, Daniel Kirschenbaum, Shiva K. Tyagarajan, Melanie Greter, Frank L. Heppner, Sarah Mundt, Burkhard Becher
IL-12 is a well-established driver of type 1 immune responses. Paradoxically, in several autoimmune conditions including neuroinflammation, IL-12 reduces pathology and exhibits regulatory properties. Yet, the mechanism and the involved cellular playe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ff94b06aab0eb1b1f1dabff952c465
https://doi.org/10.1101/2022.09.14.506749
https://doi.org/10.1101/2022.09.14.506749
Autor:
Iwona, Olejniczak, Benjamin, Campbell, Yuan-Chen, Tsai, Shiva K, Tyagarajan, Urs, Albrecht, Jürgen A, Ripperger
Publikováno v:
Frontiers in physiology. 13
Searching for food follows a well-organized decision process in mammals to take up food only if necessary. Moreover, scavenging is preferred during their activity phase. Various time-dependent regulatory processes have been identified originating fro
Autor:
Carla G. Silva, Marianne Renner, Jessica C. Pressey, Sabine Lévi, Sofia Alçada-Morais, Shiva K. Tyagarajan, Francisco Q. Gonçalves, Monique Esclapez, Christophe Leterrier, Ferran Gomez-Castro, Xavier Nicol, Nicolas Gervasi, Marion Russeau, Ricardo Gouveia Rodrigues, Stefania Zappettini, Rodrigo A. Cunha, Marta Figueiredo, Christophe Bernard, Olivier Thoumine, Eszter Szabó, Claire Montmasson, Ghislaine Caillol, Angelo R. Tomé, Paula M. Canas, Rafael Luján, Paula Agostinho
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2021, 374 (6568), ⟨10.1126/science.abk2055⟩
Science, 2021, 374 (6568), ⟨10.1126/science.abk2055⟩
Science, American Association for the Advancement of Science, 2021, 374 (6568), ⟨10.1126/science.abk2055⟩
Science, 2021, 374 (6568), ⟨10.1126/science.abk2055⟩
Synapse stabilization Early in brain development, neurons connect to each other enthusiastically. With development, an overabundance of synapses is winnowed down to refine efficiently connected circuits. Inactive synapses are prime targets for elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c449e5e2952c6dd336b316e7bd822
https://doi.org/10.5167/uzh-214098
https://doi.org/10.5167/uzh-214098
Autor:
Shiva K. Tyagarajan, Giovanna Bosshard, Benjamin F. N. Campbell, Jean-Marc Fritschy, Simon Früh
Publikováno v:
Journal of Neurochemistry. 147:477-494
In dissociated neuronal cultures the absence of spatial and temporal cues causes the emergence of mismatched synapses, where post-synaptic proteins of GABAergic synapses are in part apposed to glutamatergic pre-synaptic terminals and vice versa. This
Autor:
Yuan-Chen Tsai, Mohammad Hleihil, Kanako Otomo, Andrin Abegg, Anna Cavaccini, Patrizia Panzanelli, Teresa Cramer, Kim David Ferrari, Matthew J.P. Barrett, Giovanna Bosshard, Theofanis Karayannis, Bruno Weber, Jillian L. Stobart, Shiva K. Tyagarajan
A diverse set of GABAA receptors (GABAARs) enable synaptic plasticity adaptations at inhibitory postsynaptic sites in collaboration with the scaffolding protein gephyrin. Early studies helped to identify distinctions between GABAAR subtypes allocated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7fd2aff0c65ae3671aacdabde34ecc4
https://doi.org/10.1101/2020.11.25.397877
https://doi.org/10.1101/2020.11.25.397877