Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Shiva K, Tyagarajan"'
Autor:
Yuan-Chen Tsai, Mohammad Hleihil, Kanako Otomo, Andrin Abegg, Anna Cavaccini, Patrizia Panzanelli, Teresa Cramer, Kim David Ferrari, Matthew J. P. Barrett, Giovanna Bosshard, Theofanis Karayannis, Bruno Weber, Shiva K. Tyagarajan, Jillian L. Stobart
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Gephyrin is the main scaffolding protein at inhibitory postsynaptic sites, and its clusters are the signaling hubs where several molecular pathways converge. Post-translational modifications (PTMs) of gephyrin alter GABAA receptor clustering
Externí odkaz:
https://doaj.org/article/61f06bd1f1de40d1b7c391b161388674
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103117- (2024)
Summary: Studying synapses in vivo presents challenges due to the complexity of accurately targeting and visualizing specific synaptic proteins within the brain. Here, we present a protocol for in vivo analysis of pre- and post-synaptic protein funct
Externí odkaz:
https://doaj.org/article/c5e4c1e712bb42889c63cc366e0b9ac2
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102991- (2024)
Summary: Primary hippocampal cultures grown from genetically modified mice provide a simplified context to study molecular mechanisms underlying neuronal development, synaptogenesis, and synapse plasticity in vitro. Here, we describe a simple protoco
Externí odkaz:
https://doaj.org/article/f055456a95de493fa6046d6490cdf8ba
Autor:
Teresa M.L. Cramer, Berangere Pinan-Lucarre, Anna Cavaccini, Angeliki Damilou, Yuan-Chen Tsai, Musadiq A. Bhat, Patrizia Panzanelli, Nicolas Rama, Patrick Mehlen, Dietmar Benke, Theofanis Karayannis, Jean-Louis Bessereau, Shiva K. Tyagarajan
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112947- (2023)
Summary: The molecular code that controls synapse formation and maintenance in vivo has remained quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical hippocampal synapse organizer acting through the transmembrane r
Externí odkaz:
https://doaj.org/article/5d6008f4088e4776b7758e3496236210
Publikováno v:
eLife, Vol 11 (2022)
Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein use
Externí odkaz:
https://doaj.org/article/e784d21959234feab30ac1625c083b70
Autor:
Iwona Olejniczak, Benjamin Campbell, Yuan-Chen Tsai, Shiva K. Tyagarajan, Urs Albrecht, Jürgen A. Ripperger
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Searching for food follows a well-organized decision process in mammals to take up food only if necessary. Moreover, scavenging is preferred during their activity phase. Various time-dependent regulatory processes have been identified originating fro
Externí odkaz:
https://doaj.org/article/85b09a7c79f74508875b2f595c68f952
Autor:
Marc van Oostrum, Benjamin Campbell, Charlotte Seng, Maik Müller, Susanne tom Dieck, Jacqueline Hammer, Patrick G. A. Pedrioli, Csaba Földy, Shiva K. Tyagarajan, Bernd Wollscheid
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemi
Externí odkaz:
https://doaj.org/article/798a0222f1cc45678a4c20efbeb73d27
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
GABAergic inhibitory neurotransmission contributes to diverse aspects of brain development and adult plasticity, including the expression of complex cognitive processes. This is afforded for in part by the dynamic adaptations occurring at inhibitory
Externí odkaz:
https://doaj.org/article/0ddc3fbade614ddda04f1c7f92859618
Publikováno v:
Swiss Medical Weekly, Vol 149, Iss 2122 (2019)
How the brain performs higher cognitive functions such as learning and memory is traditionally studied by investigating how neurons work. However, over the past two decades, evidence has accumulated which suggests that components of the extracellular
Externí odkaz:
https://doaj.org/article/52d2e908eb0e40899be0cde3e404fb77
Autor:
Himanish Ghosh, Luca Auguadri, Sereina Battaglia, Zahra Simone Thirouin, Khaled Zemoura, Simon Messner, Mario A. Acuña, Hendrik Wildner, Gonzalo E. Yévenes, Andrea Dieter, Hiroshi Kawasaki, Michael O. Hottiger, Hanns Ulrich Zeilhofer, Jean-Marc Fritschy, Shiva K. Tyagarajan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transm
Externí odkaz:
https://doaj.org/article/73ddc1c5e39d47848b61414b2085adaa