Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shiva Dastjerdi"'
Autor:
Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray
Publikováno v:
eLife, Vol 6 (2017)
Thorough preclinical target validation is essential for the success of drug discovery efforts. In this study, we combined chemical and genetic perturbants, including the development of a novel selective maternal embryonic leucine zipper kinase (MELK)
Externí odkaz:
https://doaj.org/article/422c1de18104465983f6eb7e8f1d7b55
Autor:
Jingyi Zhao, Vincent DiGiacomo, Mariola Ferreras-Gutierrez, Shiva Dastjerdi, Alain Ibáñez de Opakua, Jong-Chan Park, Alex Luebbers, Qingyan Chen, Aaron Beeler, Francisco J. Blanco, Mikel Garcia-Marcos
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 120(18), e2213140120 (2023). doi:10.1073/pnas.2213140120
Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by clinically approved drugs. However, it has become evident that heterotrimeric G-proteins can a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f218a939b0e793a71b7bc8dfd768d80
https://doi.org/10.1073/pnas.2213140120
https://doi.org/10.1073/pnas.2213140120
Autor:
Jingyi Zhao, Vincent DiGiacomo, Mariola Ferreras-Gutierrez, Shiva Dastjerdi, Alain Ibáñez de Opakua, Jong-Chan Park, Alex Luebbers, Qingyan Chen, Aaron Beeler, Francisco J Blanco, Mikel Garcia-Marcos
Publikováno v:
bioRxiv
Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by clinically-approved drugs. However, it has become evident that heterotrimeric G-proteins can a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1150eb9ecd83a960c08f85855f23c1cd
https://europepmc.org/articles/PMC9949157/
https://europepmc.org/articles/PMC9949157/
Autor:
Sirano Dhe-Paganon, Matthew Sonnett, Shiva Dastjerdi, James E. Bradner, Hyuk-Soo Seo, Martin Wühr, Joshiawa Paulk, Gerard L. Brien, Dennis L. Buckley, Scott A. Armstrong, David Remillard
Publikováno v:
Angewandte Chemie. 129:5832-5837
The bromodomain-containing protein BRD9, a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex, has emerged as an attractive therapeutic target in cancer. Despite the development of chemical probes targeting the BRD9 bromodomain, there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3188727eda27b9a4df3d73e0cf0a7f
https://doi.org/10.1002/ange.201611281
https://doi.org/10.1002/ange.201611281
Autor:
Dennis L. Buckley, Rhamy Zeid, Behnam Nabet, Neville E. Sanjana, Nana K. Offei-Addo, Huafeng Xie, Georg E. Winter, Feng Zhang, Justin M. Roberts, Bin E. Li, Amanda Souza, James E. Bradner, Michael A. Erb, Stuart H. Orkin, Joshiawa Paulk, Sirano Dhe-Paganon, Shiva Dastjerdi, Ophir Shalem, Thomas G. Scott, Hyuk-Soo Seo
Publikováno v:
Nature
Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion partners belies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ece45e147973aed662dc45fa329e35b
http://europepmc.org/articles/PMC5497220
http://europepmc.org/articles/PMC5497220
Autor:
Jennifer Moran, Jean J. Zhao, Shiva Dastjerdi, Hilary McLauchlan, Hyuk-Soo Seo, Sirano Dhe-Paganon, Baishan Jiang, James E. Bradner, Nathanael S. Gray, Behnam Nabet, Georg E. Winter, Qing Li, Yubao Wang, Tinghu Zhang, Joshiawa Paulk, Justin M. Roberts, Hai-Tsang Huang, Dennis L. Buckley, Michael J. Eck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfd94035336e0486e0cd524af934a156
https://doi.org/10.7554/elife.26693.043
https://doi.org/10.7554/elife.26693.043
Autor:
Dennis L. Buckley, Michelle A. Kelliher, Sarah Vittori, Shiva Dastjerdi, Charles Y. Lin, Justine E. Roderick, Georg E. Winter, Joshiawa Paulk, Justin M. Roberts, Christopher J. Ott, Nathanael S. Gray, Thomas G. Scott, Andreas Mayer, Michael A. Erb, Jaime M. Reyes, Calla M. Olson, Rhamy Zeid, L. Stirling Churchman, Kate C. Lachance, Amanda Souza, Sophie Bauer, James E. Bradner, Julia di Iulio
Publikováno v:
Molecular Cell
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on a global scale. Prior research using small-mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40255eeaedd9c93707d9da3e9d588953
https://europepmc.org/articles/PMC5663500/
https://europepmc.org/articles/PMC5663500/
Autor:
Thomas G. Scott, Georg E. Winter, F. Zhang, Shiva Dastjerdi, Michael A. Erb, Neville E. Sanjana, Ophir Shalem, James Elliot Bradner, Dennis L. Buckley
Publikováno v:
European Journal of Cancer. 69:S85-S86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c260c9560e03e5b58753eb7af455f153
https://doi.org/10.1016/s0959-8049(16)32850-7
https://doi.org/10.1016/s0959-8049(16)32850-7