Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Shiv K, Singh"'
Publikováno v:
Physics Access, Vol 4, Iss 2, Pp 74-84 (2024)
There have been potential public health risks associated with the use of soil and rock from mining locations in North-Eastern Nigeria. This research evaluates the natural hazard parameters of soil and rock specimens obtained from mining locations in
Externí odkaz:
https://doaj.org/article/50e5bb494c484d5aac942599fdaaf942
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
One of the most deadly and aggressive cancers in the world, pancreatic ductal adenocarcinoma (PDAC), typically manifests at an advanced stage. PDAC is becoming more common, and by the year 2030, it is expected to overtake lung cancer as the second gr
Externí odkaz:
https://doaj.org/article/bb64a3116b7f44199801904723b0f8bc
Autor:
Zhe Zhang, Xin Wang, Feda H. Hamdan, Anna Likhobabina, Shilpa Patil, Lena Aperdannier, Madhobi Sen, Jacobe Traub, Albrecht Neesse, André Fischer, Argyris Papantonis, Shiv K. Singh, Volker Ellenrieder, Steven A. Johnsen, Elisabeth Hessmann
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 5, Pp 1219-1246 (2023)
Background & Aims: Loss of AT-rich interactive domain-containing protein 1A (ARID1A) fosters acinar-to-ductal metaplasia (ADM) and pancreatic carcinogenesis by down-regulating transcription programs controlling acinar cell identity. However, how ARID
Externí odkaz:
https://doaj.org/article/eb30d11bebe1451192c01dfee4b0bc4b
Autor:
Laura Urbach, Shiv K. Singh
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/828dd96b8f5044f48263d525dfbdf434
Autor:
Niklas Krebs, Lukas Klein, Florian Wegwitz, Elisa Espinet, Hans Carlo Maurer, Mengyu Tu, Frederike Penz, Stefan Küffer, Xingbo Xu, Hanibal Bohnenberger, Silke Cameron, Marius Brunner, Albrecht Neesse, Uday Kishore, Elisabeth Hessmann, Andreas Trumpp, Philipp Ströbel, Rolf A. Brekken, Volker Ellenrieder, Shiv K. Singh
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Metastatic pancreatic cancer (PDAC) has a poor clinical outcome with a 5-year survival rate below 3%. Recent transcriptome profiling of PDAC biopsies has identified 2 clinically distinct subtypes — the “basal-like” (BL) subtype with poor progno
Externí odkaz:
https://doaj.org/article/f1f4891754d64053be21530accf7b577
Autor:
Christoph Ammer-Herrmenau, Nina Pfisterer, Tim van den Berg, Ivana Gavrilova, Ahmad Amanzada, Shiv K. Singh, Alaa Khalil, Rohia Alili, Eugeni Belda, Karine Clement, Ahmed Abd El Wahed, ElSagad Eltayeb Gady, Martin Haubrock, Tim Beißbarth, Volker Ellenrieder, Albrecht Neesse
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
ABSTRACT The advent of high-throughput sequencing techniques has recently provided an astonishing insight into the composition and function of the human microbiome. Next-generation sequencing (NGS) has become the gold standard for advanced microbiome
Externí odkaz:
https://doaj.org/article/cd94289276a2419f9d54198f4ccd27cc
Autor:
Iswarya Ramu, Sören M. Buchholz, Melanie S. Patzak, Robert G. Goetze, Shiv K. Singh, Frances M. Richards, Duncan I. Jodrell, Bence Sipos, Philipp Ströbel, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 161-168 (2019)
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterised by extensive matrix deposition that has been implicated in impaired drug delivery and therapeutic resistance. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular
Externí odkaz:
https://doaj.org/article/bdd07b0e60bc40a3bd3995e138dddca8
Autor:
Sabrina A. Maisel, Derrick Broka, Benjamin Atwell, Thomas Bunch, Robert Kupp, Shiv K. Singh, Shwetal Mehta, Joyce Schroeder
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases is overexpressed and correlates with poor prognosis and decreased survival in many cancers. The receptor family has been therapeutically tar
Externí odkaz:
https://doaj.org/article/0983c75525ed469d97528a915e6a4950
Autor:
Luisa Klemke, Clara F. Fehlau, Nadine Winkler, Felicia Toboll, Shiv K. Singh, Ute M. Moll, Ramona Schulz-Heddergott
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Missense p53 mutations (mutp53) occur in approx. 70% of pancreatic ductal adenocarcinomas (PDAC). Typically, mutp53 proteins are aberrantly stabilized by Hsp90/Hsp70/Hsp40 chaperone complexes. Notably, stabilization is a precondition for specific mut
Externí odkaz:
https://doaj.org/article/14c0807c67654aea8d92c521a9be390e
Autor:
Syreeta DeCordova, Abhishek Shastri, Anthony G. Tsolaki, Hadida Yasmin, Lukas Klein, Shiv K. Singh, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor prognosis, despite surgical resection combined with radio- and chemotherapy. The major clinical obstacles contributing to poor GBM prognosis are late diagnosis, diff
Externí odkaz:
https://doaj.org/article/bf79d88485354297a67885c79f3e863c