Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Shiv I. S. Grewal"'
Autor:
Gobi Thillainadesan, Hua Xiao, Sahana Holla, Jothy Dhakshnamoorthy, Lisa M. Miller Jenkins, David Wheeler, Shiv I. S. Grewal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, includin
Externí odkaz:
https://doaj.org/article/5700ae1f518e43c0ae8fc278a9926f5f
Autor:
Guodong Xie, Tommy V. Vo, Gobi Thillainadesan, Sahana Holla, Beibei Zhang, Yiyang Jiang, Mengqi Lv, Zheng Xu, Chongyuan Wang, Vanivilasini Balachandran, Yunyu Shi, Fudong Li, Shiv I. S. Grewal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodime
Externí odkaz:
https://doaj.org/article/4e751db81f374d0581b9e726b90ed9a9
Publikováno v:
Nature structuralmolecular biology. 29(9)
Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is nucleated at specific genomic sites but can self-propagate across extended domains and, indeed, generations. Self-propagation requires Clr4/Suv39h methyltransferase recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b98a42388cdf66b25105a75fd392e5c
https://pubmed.ncbi.nlm.nih.gov/36064597
https://pubmed.ncbi.nlm.nih.gov/36064597
Publikováno v:
Genetics
Heterochromatin enriched in histone H3 lysine 9 methylation (H3K9me) and HP1 proteins coats chromosomal domains throughout the eukaryotic genome to regulate gene expression and maintain genome stability. How heterochromatin assembly mechanisms are...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da567b86105790e2f3f1387bdce58983
https://doi.org/10.1534/genetics.119.302256
https://doi.org/10.1534/genetics.119.302256
Autor:
David C. Wheeler, Amber R Cutter DiPiazza, Shiv I. S. Grewal, Sahana Holla, Nitika Taneja, Jothy Dhakshnamoorthy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance In multicellular organisms, a single genome gives rise to a multitude of cell types by enforcing appropriate gene expression patterns. Epigenetic mechanisms involving modification of histones, including tri-methylation of histone H3 lysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882cadd22e012c96f791085d81235d98
http://europepmc.org/articles/PMC8179192
http://europepmc.org/articles/PMC8179192
Autor:
David A. Wheeler, Nathan N. Lee, Yi Wei, Shiv I. S. Grewal, Jothy Dhakshnamoorthy, Martin Zofall, Lixia Pan, Ling-ling Sun
Publikováno v:
Nat Cell Biol
Cell proliferation and differentiation require signalling pathways that enforce appropriate and timely gene expression. We find that Tor2, the catalytic subunit of the TORC1 complex in fission yeast, targets a conserved nuclear RNA elimination networ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b0ac78a14c45380f10bed2b798772b
https://europepmc.org/articles/PMC9260697/
https://europepmc.org/articles/PMC9260697/
Autor:
Jothy Dhakshnamoorthy, Sahana Holla, Hua Xiao, Gobi Thillainadesan, David C. Wheeler, Lisa M. Miller Jenkins, Shiv I. S. Grewal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Long non-coding RNAs (lncRNAs) are components of epigenetic control mechanisms that ensure appropriate and timely gene expression. The functions of lncRNAs are often mediated through associated gene regulatory activities, but how lncRNAs are distingu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887e072995f88e1d45acb6b2cdc00781
https://doi.org/10.1038/s41467-020-16280-y
https://doi.org/10.1038/s41467-020-16280-y
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e141 (2007)
Meiotic recombination is initiated by DNA double-strand breaks (DSBs) made by Spo11 (Rec12 in fission yeast), which becomes covalently linked to the DSB ends. Like recombination events, DSBs occur at hotspots in the genome, but the genetic factors re
Externí odkaz:
https://doaj.org/article/b49598dd440744499602cd1523a1bde3
Autor:
Vanivilasini Balachandran, H. Diego Folco, Tomoyasu Sugiyama, Venkata R. Chalamcharla, Jothy Dhakshnamoorthy, Takeshi Mizuguchi, Shiv I. S. Grewal, Gobi Thillainadesan, Martin Zofall
Publikováno v:
Nature
Uniparental disomy (UPD), in which an individual contains a pair of homologous chromosomes originating from only one parent, is a frequent phenomenon that is linked to congenital disorders and various cancers. UPD is thought to result mostly from pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6574fb76538f9a321006f5efa00f33
https://doi.org/10.1038/nature21372
https://doi.org/10.1038/nature21372
Autor:
Gobi, Thillainadesan, Hua, Xiao, Sahana, Holla, Jothy, Dhakshnamoorthy, Lisa M Miller, Jenkins, David, Wheeler, Shiv I S, Grewal
Publikováno v:
Nature Communications
Long non-coding RNAs (lncRNAs) are components of epigenetic control mechanisms that ensure appropriate and timely gene expression. The functions of lncRNAs are often mediated through associated gene regulatory activities, but how lncRNAs are distingu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd0ec977e154f1ad70a238f83711f1ef
https://pubmed.ncbi.nlm.nih.gov/32415063
https://pubmed.ncbi.nlm.nih.gov/32415063