Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Shiuan Wey"'
1
Akademický článek
Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.
Autor: Shiuan Wey, Biquan Luo, Amy S Lee
Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39047 (2012)
GRP78, a master regulator of the unfolded protein response (UPR) and cell signaling, is required for inner cell mass survival during early embryonic development. However, little is known about its role in adult hematopoietic stem cells (HSCs) and hem
Externí odkaz: https://doaj.org/article/a2ebcd0064e2421bb6611b8a2dce1de2
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2
Akademický článek
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.
Autor: Biquan Luo, Ben S Lam, Sung Hyung Lee, Shiuan Wey, Hui Zhou, Miao Wang, Si-Yi Chen, Gregor B Adams, Amy S Lee
Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20364 (2011)
Hematopoietic stem cell (HSC) homeostasis in the adult bone marrow (BM) is regulated by both intrinsic gene expression products and interactions with extrinsic factors in the HSC niche. GRP94, an endoplasmic reticulum chaperone, has been reported to
Externí odkaz: https://doaj.org/article/78031abefcef47068e248ce0efb9a3eb
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3
Akademický článek
Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.
Autor: Changhui Mao, Miao Wang, Biquan Luo, Shiuan Wey, Dezheng Dong, Robin Wesselschmidt, Stephen Rawlings, Amy S Lee
Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10852 (2010)
Glucose-regulated protein 94 (GRP94) is one of the most abundant endoplasmic reticulum (ER) resident proteins and is the ER counterpart of the cytoplasmic heat shock protein 90 (HSP90). GRP94, a component of the GRP78 chaperone system in protein proc
Externí odkaz: https://doaj.org/article/c41164acbf7c4493a0517e180ef1108a
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4
Akademický článek
Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP.
Autor: Min Ni, Hui Zhou, Shiuan Wey, Peter Baumeister, Amy S Lee
Publikováno v: PLoS ONE, Vol 4, Iss 8, p e6868 (2009)
The unfolded protein response (UPR) is an evolutionarily conserved mechanism to allow cells to adapt to stress targeting the endoplasmic reticulum (ER). Induction of ER chaperone GRP78/BiP increases protein folding capacity; as such it represents a m
Externí odkaz: https://doaj.org/article/9b75495dbc7a4d9f816f9e129650b3a5
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8
Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Autor: Parkash S. Gill, Amy S. Lee, Zibo Li, Peter S. Conti, Stan Louie, Genyuan Zhu, Dan Li, Shuanglong Liu, Dezheng Dong, Valery Krasnoperov, Satyajit K. Mitra, Shiuan Wey, Yue Zhou, Wenming Gao, Xiuqing Li, Ren Liu
Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosphoinositide 3-kinas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26da9044398cf843fabd28d3645e0e74
https://doi.org/10.1158/1078-0432.c.6520877.v1
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9
Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Autor: Satyajit Sujit Kumar Mitra, Amy S. Lee, Shiuan Wey, Wenming Gao, Xiuqing Li, Yue Zhou, Peter S. Conti, Parkash S. Gill, Valery Krasnoperov, Ren Liu, Genyuan Zhu, Shuanglong Liu, Zibo Li, Dan Li, Dezheng Dong, Stan G. Louie
Publikováno v: Clinical Cancer Research. 19:6802-6811
Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosphoinositide 3-kinas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afc7e94810c7b208be48830f8be73bf
https://doi.org/10.1158/1078-0432.ccr-13-1106
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10
Three dimensional rendering of the mitochondrial sheath morphogenesis during mouse spermiogenesis
Autor: Shiuan Wey, Han-Chen Ho
Publikováno v: Microscopy Research and Technique. 70:719-723
In the middle piece of mouse sperm tail, the idea of the mitochondria wrapping in a sinistral (left-handed) double helical structure was generally accepted. In the existing model, mitochondria aligned in four longitudinal rows (stage 1) and twisted d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5300833ce0e8d5d9e4ddc2607735b786
https://doi.org/10.1002/jemt.20457
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