Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shiu-Feng Tung"'
Autor:
Shiu-Feng Tung, 董須豐
87
We previously identified a movable and regulable inactivation function within the central region (CRts247) of a temperature-sensitive p53 (p53ts) mutant, p53N247I. Here we demonstrated that the central regions from other p53 mutants behaved s
We previously identified a movable and regulable inactivation function within the central region (CRts247) of a temperature-sensitive p53 (p53ts) mutant, p53N247I. Here we demonstrated that the central regions from other p53 mutants behaved s
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/77030592199694368838
Autor:
Khawja A. Usmani, Dawei Yue, Zhi-Liang Chu, Abu J.M. Sadeque, Chris Carroll, Chuan Chen, Hsin-Hui Shu, Sanju Narayanan, Hussein Al-Sharmma, Dominic P. Behan, Robert M. Jones, Graeme Semple, James N. Leonard, David J. Unett, Daniel J. Buzard, Michael Morgan, Juerg Lehmann, Imelda Calderon, Shiu-Feng Tung, Woo Hyun Yoon, Xiuwen Zhu, Sangdon Han, Andrew M. Kawasaki, Amy Siu-Ting Wong, Sun Hee Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3034-3038
The design and optimization of a novel trans-1,4-dioxycyclohexane GPR119 agonist series is described. A lead compound 21 was found to be a potent and efficacious GPR119 agonist across species, and possessed overall favorable pharmaceutical properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f3b9e4db6f1603a99df66761f2f277
https://doi.org/10.1016/j.bmcl.2015.04.102
https://doi.org/10.1016/j.bmcl.2015.04.102
Autor:
Antonio Garrido Montalban, Steve Chang, Shakya Sagar, P. Douglas Boatman, Weichao Chen, Dominic P. Behan, Thuy-Anh Tran, Yunqing Shi, Young-Jun Shin, Krishnan Ashwin M, Pureza Vallar, John W. Adams, David J. Unett, Michael Morgan, Bryan A. Kramer, Biman B. Pal, Hsin-Hui Shu, Anthony C. Blackburn, Juan Ramirez, Shiu-Feng Tung, Xiaohua Chen, Tina Leakakos, Ning Zou, Abu J.M. Sadeque, Tawfik Gharbaoui, Carleton R. Sage, Anna Shifrina, Graeme Semple, Ibragim Gaidarov
Publikováno v:
Journal of medicinal chemistry. 60(3)
The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3808129dea9a6540d0ac87cf636e0752
https://pubmed.ncbi.nlm.nih.gov/28072531
https://pubmed.ncbi.nlm.nih.gov/28072531
Autor:
Young-Jun Shin, Hsin-Hui Shu, P. Douglas Boatman, Juyi Choi, Steve Chang, Michael Morgan, Graeme Semple, Peter Martens, John W. Adams, Ning Zou, David J. Unett, Yunqing Shi, Shiu-Feng Tung, Pureza Vallar, Bryan A. Kramer, Thuy-Anh Tran, Juan Ramirez
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(5)
The design and synthesis of two closely related series of prostacyclin receptor agonist compounds that showed excellent human IP receptor potency and efficacy is described. Compounds from this series showed in vivo activity after SC dosing in the mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f18b1b98bf673d82965b415adc56a6
https://pubmed.ncbi.nlm.nih.gov/25666818
https://pubmed.ncbi.nlm.nih.gov/25666818
Autor:
Luis Lopez, Daniel J. Buzard, Abu J.M. Sadeque, David J. Unett, Ching-Fen Chuang, Hsin-Hui Shu, Rohit Bhat, James N. Leonard, Sanju Narayanan, Dawei Yue, Robert M. Jones, Amy Siu-Ting Wong, Michael Morgan, Zhi-Liang Chu, Juerg Lehmann, Sun Hee Kim, Hussien A. Al-Shamma, Imelda Calderon, Kevin Whelan, Steve Chang, Shiu-Feng Tung, Tawfik Gharbaoui, Andrew M. Kawasaki, Sangdon Han
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(17)
A series of 5-fluoro-4,6-dialkoxypyrimidine GPR119 modulators were discovered and optimized for in vitro agonist activity. A lead molecule was identified that has improved agonist efficacy relative to our clinical compound (APD597) and possesses redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad2ab4757cddc23a6a0ea787351b612
https://pubmed.ncbi.nlm.nih.gov/25088191
https://pubmed.ncbi.nlm.nih.gov/25088191
Publikováno v:
Journal of Biological Chemistry. 275:12313-12320
The HCMV IE2 protein negatively autoregulates its own expression as well as represses the transactivation activity of p53. Using the repression domain of IE2 as bait in the yeast two-hybrid system, Nrf1 and Nrf2, members of the CNC-bZIP family, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87d633dba5bb5e42abab033b8737c5b
https://doi.org/10.1074/jbc.275.16.12313
https://doi.org/10.1074/jbc.275.16.12313
Publikováno v:
Journal of Biological Chemistry. 274:7748-7755
We previously identified a movable and regulable inactivation function within the central region (CRts247) of a temperature-sensitive p53 (p53(ts)) mutant, p53(N247I). Here we showed that central regions from several p53(ts) mutants behaved similarly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92071a4970180c4822ba36f9dfd8563
https://doi.org/10.1074/jbc.274.12.7748
https://doi.org/10.1074/jbc.274.12.7748
Publikováno v:
European Journal of Pharmacology. 211:359-364
The possible mechanism of immunosuppressive effect of emodin (1,3,8-trihydroxy-6-methylanthraquinone) was investigated in this study. Human mononuclear cells (10(6) cells/ml) were stimulated with 0.25% phytohemagglutinin for 24, 48 and 72 h, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4a08c4621c98e65731a2dec515f0b2
https://doi.org/10.1016/0014-2999(92)90393-i
https://doi.org/10.1016/0014-2999(92)90393-i
Publikováno v:
DNA and cell biology. 19(10)
The human cytomegalovirus IE2 is a sequence-specific DNA-binding protein. A consensus IE2-binding site (IBS) contains two copies of the dinucleotide CG separated by 10 not well-conserved but AT-rich nucleotides. In this report, we demonstrated that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668a88a759195a1032e19fe144d190bc
https://pubmed.ncbi.nlm.nih.gov/11058964
https://pubmed.ncbi.nlm.nih.gov/11058964