Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shishir Chourey"'
Autor:
Chantal Cossette, Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Rui Wang, Sophie Poulet, Irina Slobodchikova, Dajana Vuckovic, Joshua Rokach, William S. Powell
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 172
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is the only product of the proinflammatory 5-lipoxygenase pathway with potent chemoattractant effects for human eosinophils, suggesting an important role in eosinophilic diseases such as asthma. 5-Oxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065599b57e55e227f0158d83bb877771
https://pubmed.ncbi.nlm.nih.gov/35158054
https://pubmed.ncbi.nlm.nih.gov/35158054
Autor:
William S. Powell, Shishir Chourey, Joshua Rokach, Qiuji Ye, Chintam Nagendra Reddy, Chantal Cossette, Lisa A. Miller
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: The 5-lipoxygenase product, 5-oxo-ETE (5-oxo-6,-8,11,14-eicosatetraenoic acid), is a potent chemoattractant for eosinophils and neutrophils. However, little is known about its pathophysiological role because of the lack of a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7aea85ec50a6e25534707858b7a254d
https://pubmed.ncbi.nlm.nih.gov/34766334
https://pubmed.ncbi.nlm.nih.gov/34766334
Autor:
William S. Powell, Joshua Rokach, Lisa A. Miller, Qiuji Ye, Chantal Cossette, Shishir Chourey, Chintam Nagendra Reddy
Publikováno v:
Br J Pharmacol
Background and purpose 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), acting via the OXE receptor, is unique among 5-lipoxygenase products in its ability to directly induce human eosinophil migration, suggesting its involvement in eosinophilic di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec6ff087977310e4da4e105fc49dad8
https://doi.org/10.1111/bph.14872
https://doi.org/10.1111/bph.14872
Autor:
Chintam Nagendra Reddy, William S. Powell, Rui Wang, Irina Slobodchikova, Dajana Vuckovic, Chantal Cossette, Qiuji Ye, Shishir Chourey, Joshua Rokach, Sylvie Gravel
Publikováno v:
Journal of Medicinal Chemistry. 61:5934-5948
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent lipid mediator that induces tissue eosinophilia via the selective OXE receptor (OXE-R), which is an attractive therapeutic target in eosinophilic diseases. We previously identified indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ba1b9514fafbcf7d0a0c6f7174cafd
https://doi.org/10.1021/acs.jmedchem.8b00154
https://doi.org/10.1021/acs.jmedchem.8b00154
Autor:
Sylvie Gravel, Joshua Rokach, Dajana Vuckovic, Qiuji Ye, Hussam Alhamza, Vivek Gore, Irina Slobodchikova, Shishir Chourey, William S. Powell, Chintam Nagendra Reddy, Chantal Cossette
Publikováno v:
European Journal of Pharmaceutical Sciences. 115:88-99
We previously identified the indole 264 as a potent in vitro antagonist of the human OXE receptor that mediates the actions of the powerful eosinophil chemoattractant 5-oxo-ETE. No antagonists of this receptor are currently commercially available or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ddcd174515e92b81f7cd0ac5af07f3
https://doi.org/10.1016/j.ejps.2018.01.021
https://doi.org/10.1016/j.ejps.2018.01.021
Autor:
Dajana Vuckovic, William S. Powell, Shishir Chourey, Qiuji Ye, Joshua Rokach, Irina Slobodchikova, Chintam Nagendra Reddy, Sylvie Gravel, Matthias Zeller, Chantal Cossette
Publikováno v:
Biochemical Pharmacology. 138:107-118
We have developed a selective indole antagonist (230) targeting the OXE receptor for the potent eosinophil chemoattractant 5-oxo-ETE (5-oxo-6,8,11,14-eicosatetraenoic acid), that may be useful for the treatment of eosinophilic diseases such as asthma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca94188500919af67dda4cf69b48d5c
https://doi.org/10.1016/j.bcp.2017.04.031
https://doi.org/10.1016/j.bcp.2017.04.031
Autor:
Dajana Vuckovic, Sylvie Gravel, Rui Wang, Qiuji Ye, Chantal Cossette, Shishir Chourey, Joshua Rokach, William S. Powell, Chintam Nagendra Reddy, Irina Slobodchikova
Publikováno v:
Br J Pharmacol
Background and purpose The 5-lipoxygenase product 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE), acting through the OXE receptor, is a potent eosinophil chemoattractant that may be an important proinflammatory mediator in eosinophilic disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cf689b3a8f33c3d0a77c06617c8758
https://pubmed.ncbi.nlm.nih.gov/31655025
https://pubmed.ncbi.nlm.nih.gov/31655025
Autor:
Joshua Rokach, Rui Wang, Chintam Nagendra Reddy, Jaganmohan R. Anumolu, Shishir Chourey, Gail E. Grant, Sashikala Sivendran, Pranav Patel, Qiuji Ye, William S. Powell
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:116-125
Arachidonic acid (AA) is converted to biologically active metabolites by different pathways, one of the most important of which is initiated by 5-lipoxygenase (5-LO). 5-Hydroxyeicosatetraenoic acid (5-HETE), although possessing only weak biological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb41df4858ac5bec0e90ac183849ef4d
https://doi.org/10.1016/j.bmc.2016.10.017
https://doi.org/10.1016/j.bmc.2016.10.017
Autor:
Joshua Rokach, Chintam Nagendra Reddy, Qiuji Ye, Sylvie Gravel, Shishir Chourey, William S. Powell
Publikováno v:
Tetrahedron Letters. 56:6896-6899
Enantioselective synthesis of highly potent 5-oxo-ETE receptor antagonists 5a and 6a with a high level of enantiomeric purity is described. The main feature of this work is the simple and efficient synthesis of the bi-functionalized 3-(S)-methyl-pent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ee73b272dc011b58fb382ddb7444124
https://doi.org/10.1016/j.tetlet.2015.10.097
https://doi.org/10.1016/j.tetlet.2015.10.097
Autor:
Rui Wang, Nagendra Reddy Chintam, Joshua Rokach, Qiuji Ye, Sylvie Gravel, Shishir Chourey, William S. Powell
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(20)
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8486dc0feab6dfc5e39e7908640af87d
https://pubmed.ncbi.nlm.nih.gov/28943042
https://pubmed.ncbi.nlm.nih.gov/28943042