Zobrazeno 1 - 10
of 334
pro vyhledávání: '"Shiroshi Shibuya"'
Autor:
Tetsuo Murano, Hiroaki Takechi, Yoko Yuasa, Tsutomu Yokomatsu, Ikuko Umesue, Shinji Soeda, Hiroshi Shimeno, Shiroshi Shibuya
Publikováno v:
ARKIVOC, Vol 2003, Iss 8, Pp 256-266 (2003)
Externí odkaz:
https://doaj.org/article/3dbb37055bc24d00a938b7e0d626c769
Autor:
Tsutomu Yokomatsu, Reiko Eyanagi, Akihisa Toda, Shinji Soeda, Hiroshi Shimeno, Sadao Hikishima, Akira Sakata, Takashi Ochiai, Shiroshi Shibuya
Publikováno v:
Immunology. 122:54-64
Lipopolysaccharide (LPS) and inflammatory cytokines cause activation of sphingomyelinases (SMases) and subsequent hydrolysis of sphingomyelin (SM) to produce a lipid messenger ceramide. The design of SMase inhibitors may offer new therapies for the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41e07842b30cb99ca04989abe24fe2c
https://doi.org/10.1111/j.1365-2567.2007.02612.x
https://doi.org/10.1111/j.1365-2567.2007.02612.x
Autor:
Shiroshi Shibuya, Shinji Soeda, Tsutomu Yokomatsu, Satoru Koyanagi, Machiko Isobe, Sadao Hikishima, Hiroshi Shimeno
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1660-1670
9-(5′,5′-Difluoro-5′-phosphonopentyl)guanine (DFPP-G) and its hypoxanthine analogue (DFPP-H) were modified by introducing a methyl group to all possible positions of the linker connecting a purine and difluoromethylenephosphonic acid moiety to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ee74e92ae4ac281e3c6090e71bfd21
https://doi.org/10.1016/j.bmc.2005.10.017
https://doi.org/10.1016/j.bmc.2005.10.017
Publikováno v:
Tetrahedron. 62:54-65
Phosphonic acid analogues of acylcarnitine were prepared in an optically active form expecting CPT I inhibitory activities. The synthetic methodology was based on catalytic asymmetric dihydroxylation of β,γ-unsaturated phosphonates and subsequent r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56407cd3327493fbc4dfd1000127009c
https://doi.org/10.1016/j.tet.2005.09.126
https://doi.org/10.1016/j.tet.2005.09.126
Publikováno v:
Synthesis. 2005:187-192
An alternative synthesis of 1,3-propanediol 1 having a diethoxyphosphoryldifluoroethyl group was examined. The method readily provided a multi-gram quantity of 1. The propanediol 1 was chemo-enzymatically transformed to acyclic nucleotide analogues f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb691c76835426ea5d030ceb02099d2
https://doi.org/10.1055/s-2004-834941
https://doi.org/10.1055/s-2004-834941
Autor:
Shiroshi Shibuya
Publikováno v:
YAKUGAKU ZASSHI. 124:725-749
This paper covers recent publications from our laboratory on the synthesis of a variety of phosphonate and phosphinate derivatives. New methods for the enantioselective synthesis of alpha-hydroxyphosphonates were established by Lewis acid-mediated cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f377d581bd2db17b89feccf0c44f8db0
https://doi.org/10.1248/yakushi.124.725
https://doi.org/10.1248/yakushi.124.725
Publikováno v:
Synlett. 2004:2505-2508
γ-Amino-β-hydroxyphosphonates, useful intermediates for the synthesis of phosphonic acid analogues of carnitine, were prepared as their protected derivatives in an enantioselective manner from β,γ-unsaturated phosphonatesthrough asymmetric dihydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26c81965979ccf32a4b1f384e7adab52
https://doi.org/10.1055/s-2004-834792
https://doi.org/10.1055/s-2004-834792
Publikováno v:
Tetrahedron Letters. 45:6713-6716
A chiral synthesis of α-hydroxy-H-phosphinates was achieved via lipase-catalyzed hydrolysis of acetate precursors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c439dffbb86e3d3febacf3b8540986
https://doi.org/10.1016/j.tetlet.2004.07.066
https://doi.org/10.1016/j.tetlet.2004.07.066
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 60:1417-1424
Purine-nucleoside phosphorylase (PNP) deficiency in humans leads to inhibition of the T-cell response. Potent membrane-permeable inhibitors of this enzyme are therefore considered to be potential immunosuppressive agents. The binary complex of the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcce119b92601d54d71c41255db53456
https://doi.org/10.1107/s0907444904013861
https://doi.org/10.1107/s0907444904013861
Publikováno v:
Tetrahedron. 59:10223-10230
A synthetic approach to a new type of acyclic nucleotide analogues 8 and 9 was examined. The design was based on acyclic modification of MRS 2179, a P2Y 1 -antagonist, and replacement of one of two phosphate groups characterized by MRS 2179 with an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e87259886cf167ce57cd3c08acd210e
https://doi.org/10.1016/j.tet.2003.10.064
https://doi.org/10.1016/j.tet.2003.10.064