Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shiroh Matsukura"'
Autor:
Takeshi Urano, Tsunehiro Mukai, Hidenobu Soejima, Shuzo Matsuo, Shiroh Matsukura, Shinichi Kudo, Wei Zhao, Ken Higashimoto, Tetsuji Nakagawachi, Keiichiro Joh
Publikováno v:
Journal of Biochemistry. 137:431-440
Silencing of the O (6)-methylguanine-DNA methyltransferase (MGMT) gene, a key to DNA repair, is involved in carcinogenesis. Recent studies have focused on DNA hypermethylation of the promoter CpG island. However, cases showing silencing with DNA hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7ed49658852ccb9a5ab0c8e296ac54
https://doi.org/10.1093/jb/mvi048
https://doi.org/10.1093/jb/mvi048
Autor:
Ken Higashimoto, Yoshihiko Kitajima, Tsunehiro Mukai, Takeshi Urano, Shiroh Matsukura, Tetsuji Nakagawachi, Kohji Miyazaki, Makoto Takeuchi, Wei Zhao, Masahiro Nakayama, Keiichiro Joh, Hidenobu Soejima, Mitsuo Oshimura
Publikováno v:
Oncogene. 23:4380-4388
The putative tumor suppressor CDKN1C is an imprinted gene at 11p15.5, a well-known imprinted region often deleted in tumors. The absence of somatic mutations and the frequent diminished expression in tumors would suggest that CDKN1C expression is reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4a96ab4105851a8de2fe4dbbcd1bf5
https://doi.org/10.1038/sj.onc.1207576
https://doi.org/10.1038/sj.onc.1207576
Publikováno v:
Gastric Cancer. 6:86-95
Disorders of the DNA repair system that protects against alkylating mutagens are known to play an important role in carcinogenesis.We investigated the expression of the DNA repair enzyme that protects against alkylating mutagens, O(6)-methylguanine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62495cbef147c8d5f64d34cea58250bb
https://doi.org/10.1007/s10120-003-0213-z
https://doi.org/10.1007/s10120-003-0213-z
Autor:
Tetsuji Nakagawachi, Shiroh Matsukura, Yusaku Nakabeppu, Hiroyuki Yakushiji, Akiomi Ogawa, Kohji Miyazaki, Mutsuo Sekiguchi, Masao Fukuhara, Tsunehiro Mukai, Hidenobu Soejima
Publikováno v:
British Journal of Cancer
Inactivations of DNA repair genes, O(6)-methylguanine-DNA methyltransferase (MGMT) and hMLH1, by promoter hypermethylation have been reported in several types of primary human neoplasia. This epigenetic inactivation mechanism remains elusive in hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4828afa4ebc63280ee472088b37d4c
https://doi.org/10.1038/sj.bjc.6600743
https://doi.org/10.1038/sj.bjc.6600743
Autor:
Mutsuo Sekiguchi, Akiomi Ogawa, Kohji Miyazaki, Hiroyuki Yakushiji, Shiroh Matsukura, Yongxin Chen
Publikováno v:
Journal of surgical oncology. 82(3)
Background and Objectives O6-methylguanine-DNA methyltransferase (MGMT) and human Mut L homologue 1 (hMLH1) are proteins that play an important role in DNA repair. No reports have yet described whether deficient MGMT and hMLH1 expression correlates w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb14443b3f332d77d13fed95d3723ea
https://pubmed.ncbi.nlm.nih.gov/12619064
https://pubmed.ncbi.nlm.nih.gov/12619064
Autor:
Shiroh Matsukura, Hiroyuki Yakushiji, Naohiko Kohya, Mutsuo Sekiguchi, Yoshihiko Kitajima, Yusaku Nakabeppu, Kenji Kitahara, Kohji Miyazaki, Masao Fukuhara
Publikováno v:
Annals of surgical oncology. 9(4)
O 6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups fromO 6-methylguanine to itself. Alkylation of DNA at theO 6 position of guanine is an important step in the induction of mutations in the organism by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05cd78775427d4b524282b7f42321fe
https://pubmed.ncbi.nlm.nih.gov/11986189
https://pubmed.ncbi.nlm.nih.gov/11986189
Autor:
Katsumi Harimaya, Kohji Miyazaki, Akiomi Ogawa, Hiroyuki Yakushiji, Yusaku Nakabeppu, Mutsuo Sekiguchi, Shiroh Matsukura
Publikováno v:
Annals of surgical oncology. 8(10)
Background: O 6-Methylguanine-DNA methyltransferase MGMT is an enzyme that repairs O 6-methylguanine, a promutagenic DNA base damaged by endogenous and environmental alkylating agents. There are few reports that describe whether or not abnormal MGMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8f7238d4972f8f0b8305f6aac90265
https://pubmed.ncbi.nlm.nih.gov/11776495
https://pubmed.ncbi.nlm.nih.gov/11776495
Autor:
Shiroh Matsukura, Michito Mori, Yusaku Nakabeppu, Masao Fukuhara, Akihiro Iyama, Kohoji Miyazaki, Tohoru Ishibashi, Akiomi Ogawa, Mutsuo Sekiguchi, Hiroyuki Yakushiji
Publikováno v:
Gastroenterology. 118:A1034
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9654e1d4231159b0cc3de4f2202278
https://doi.org/10.1016/s0016-5085(00)86287-3
https://doi.org/10.1016/s0016-5085(00)86287-3
Autor:
Haruhito Harada, Tsunehiro Mukai, Hideki Matsuzaki, Kohji Miyazaki, Yuji Satoh, Yoshihiko Kitajima, Koichi Furukawa, Takeshi Urano, Tetsuji Nakagawachi, Mitsuru Emi, Yusaku Nakabeppu, Shiroh Matsukura, Mutsuo Sekiguchi, Wei Zhao, Ken Higashimoto, Shinichi Kudo, Hidenobu Soejima
Publikováno v:
Scopus-Elsevier
O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9458637b08b7e28b408425e41833d822
http://www.scopus.com/inward/record.url?eid=2-s2.0-9144271660&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-9144271660&partnerID=MN8TOARS
