Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Shiroh Iwanaga"'
Autor:
Kofi Dadzie Kwofie, Emmanuel Pacia Hernandez, Anisuzzaman, Hayato Kawada, Yuki Koike, Sana Sasaki, Takahiro Inoue, Kei Jimbo, Fusako Mikami, Danielle Ladzekpo, Rika Umemiya-Shirafuji, Kayoko Yamaji, Tetsuya Tanaka, Makoto Matsubayashi, Md Abdul Alim, Samuel Kweku Dadzie, Shiroh Iwanaga, Naotoshi Tsuji, Takeshi Hatta
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract RNA activation (RNAa) is a burgeoning area of research in which double-stranded RNAs (dsRNAs) or small activating RNAs mediate the upregulation of specific genes by targeting the promoter sequence and/or AU-rich elements in the 3′- untrans
Externí odkaz:
https://doaj.org/article/c6cd9cc344bf44b58629939549b274c1
Publikováno v:
eLife, Vol 12 (2024)
Gametocytes play key roles in the Plasmodium lifecycle. They are essential for sexual reproduction as precursors of the gametes. They also play an essential role in parasite transmission to mosquitoes. Elucidation of the gene regulation at this stage
Externí odkaz:
https://doaj.org/article/b61fd853bc1d41a3aa2a575f6bf0cc82
Autor:
Faustus Akankperiwen Azerigyik, Astri Nur Faizah, Daisuke Kobayashi, Michael Amoa-Bosompem, Ryo Matsumura, Izumi Kai, Toshinori Sasaki, Yukiko Higa, Haruhiko Isawa, Shiroh Iwanaga, Tomoko Ishino
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Background The Getah virus (GETV) is a mosquito-borne Alphavirus (family Togaviridae) that is of significant importance in veterinary medicine. It has been associated with major polyarthritis outbreaks in animals, but there are insufficient
Externí odkaz:
https://doaj.org/article/667dc764cefa4ebd81e4c7800b2ac045
Autor:
Shiroh Iwanaga, Rie Kubota, Tsubasa Nishi, Sumalee Kamchonwongpaisan, Somdet Srichairatanakool, Naoaki Shinzawa, Din Syafruddin, Masao Yuda, Chairat Uthaipibull
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Plasmodium falciparum malaria is treated using artemisinin combination therapy (ACT), in which artemisinin is supplied along with partner drugs such as mefloquine, piperaquine, and lumefantrine. However, resistance has been reported in endemic region
Externí odkaz:
https://doaj.org/article/994ca7c9bea84ed992fa78d880984241
Autor:
Emi Hashizaki, Miwa Sasai, Daisuke Okuzaki, Tsubasa Nishi, Takashi Kobayashi, Shiroh Iwanaga, Masahiro Yamamoto
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Toxoplasma gondii secretes various virulence effector molecules into host cells to disrupt host interferon-γ (IFN-γ)-dependent immunity. Among these effectors, ROP18 directly phosphorylates and inactivates IFN-inducible GTPases, such as im
Externí odkaz:
https://doaj.org/article/8cce4e57ccc947a185c4c4f86535081e
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Malaria transmission to humans begins with sporozoite infection of the liver. The elucidation of gene regulation during the sporozoite stage will promote the investigation of mechanisms of liver infection by this parasite and contribute to t
Externí odkaz:
https://doaj.org/article/a5f4d958171e41f5ac4814595e0309a2
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1010890 (2023)
Gametocyte development is a critical step in the life cycle of Plasmodium. Despite the number of studies on gametocyte development that have been conducted, the molecular mechanisms regulating this process remain to be fully understood. This study in
Externí odkaz:
https://doaj.org/article/59decff1b8a1460c895491b6e2e372e9
Autor:
Samiratu Mahazu, Wakana Sato, Alafate Ayibieke, Isaac Prah, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Recently, the emergence and rapid dissemination of extended-spectrum beta-lactamase (ESBL)-producing bacteria, particularly of the family Enterobacteriaceae, has posed serious healthcare challenges. Here, we determined the antimicrobial susc
Externí odkaz:
https://doaj.org/article/06e23a357def48db9f2bde5be2f16c49
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The CRISPR/Cas9 system is a powerful genetic engineering technology for Plasmodium falciparum. We here report further improvement of the CRISPR/Cas9 system by combining the Cas9-expressing parasite with a liner donor template DNA. The Cas9-e
Externí odkaz:
https://doaj.org/article/b96891bd3e9d4dfa8a10bff40afe263f
Autor:
Yang Xu, Ziyou Zhou, Brad Brooks, Tammy Ferguson, Judy Obliosca, Jing Huang, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Yukiko Tsuji, Huitang Zhang, Christina C. Luo, Xunqing Jiang, Xiang-Peng Kong, Moriya Tsuji, Christopher K. Tison
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Developing a safe and effective malaria vaccine is critical to reducing the spread and resurgence of this deadly disease, especially in children. In recent years, vaccine technology has seen expanded development of subunit protein, peptide, and nucle
Externí odkaz:
https://doaj.org/article/01b7c35a60b940dea07528b88ec9daeb