Optogenetic activation of serotonergic neurons changes masticatory movement in freely moving mice

Autor: Masanori Dantsuji, Ayako Mochizuki, Kiyomi Nakayama, Mitsuko Kanamaru, Masahiko Izumizaki, Kenji F. Tanaka, Tomio Inoue, Shiro Nakamura

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract The serotonergic system modulates the neural circuits involved in jaw movement; however, the role of serotonin (5-HT) neurons in masticatory movement remains unclear. Here, we investigated the effect of selective activation of 5-HT neurons i

Externí odkaz: https://doaj.org/article/80e1bd2e36e94e95a63fb8a8b7005d58

Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane

Autor: Naohito Ito, Mayumi Tsuji, Naoki Adachi, Shiro Nakamura, Avijite Kumer Sarkar, Kensuke Ikenaka, César Aguirre, Atsushi Michael Kimura, Yuji Kiuchi, Hideki Mochizuki, David B. Teplow, Kenjiro Ono

Publikováno v: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-10 (2023)

Abstract α-Synuclein (αS), the causative protein of Parkinson’s disease and other α-synucleinopathies, aggregates from a low molecular weight form (LMW-αS) to a high molecular weight αS oligomer (HMW-αSo). Aggregated αS accumulates intracell

Externí odkaz: https://doaj.org/article/228a52955c864033bfc56882d062d772

Final Analysis of COVID-19 Patients With Inflammatory Bowel Disease in Japan (J-COSMOS): A Multicenter Registry Cohort Study

Autor: Hiroshi Nakase, Yuki Hayashi, Yoshihiro Yokoyama, Takayuki Matsumoto, Minoru Matsuura, Hideki Iijima, Katsuyoshi Matsuoka, Naoki Ohmiya, Shunji Ishihara, Fumihito Hirai, Daiki Abukawa, Tadakazu Hisamatsu, Makoto Sasaki, Masahiro Iizuka, Mikihiro Fujiya, Fukunori Kinjo, Shiro Nakamura, Noriko Kamata, Yuri Etani, Fumiaki Ueno, Sakiko Hiraoka, Takeo Kondo, Takashi Kagaya, Makoto Naganuma, Kiyonori Kobayashi, Taku Kobayashi, Shuji Yamamoto, Yuji Naito, Yoki Furuta, Keichi Mitsuyama, Yu Hashimoto, Katsuhiro Arai, Shingo Kato, Itaru Iwama, Motohiro Esaki, Hiroki Tanaka, Satoshi Motoya, Atsuo Maemoto, Toshifumi Ashida, Nobuaki Nishimata, Shigeaki Aono, Akira Andoh, Hironori Yamamoto, Toshiaki Shimizu, Maeda Yasuharu, Kenji Kinoshita, Katuyuki Fukuda, Jun Kato, Ken Takeuchi, Masakazu Nagahori, Masakatsu Fukuzawa, Masayuki Saruta, Takayoshi Suzuki, Michio Itabashi, Masaru Shinozaki, Soichiro Ishihara, Naoki Yoshimura, Yoichi Kakuta, Kenichi Takahashi, Keiichi Tominaga, Ryosuke Sakemi, Sohachi Nanjo, Shusaku Yoshikawa, Keiji Ozeki, Ayako Fuchigami, Takehiko Katsurada, Kenji Watanabe, Hirotake Sakuraba, Takashi Hisabe, Shigeru Iwase, Ryota Hokari, Katsuhiko Nakai, Takeshi Ueda, Shojiro Yamamoto, Kazutaka Koganei, Reiko Kunisaki, Akira Hokama

Publikováno v: Gastro Hep Advances, Vol 2, Iss 8, Pp 1056-1065 (2023)

Background and Aims: Japan has experienced 8 waves of the coronavirus disease 2019 (COVID-19) outbreak over the past 3 years, resulting in an increasing number of deaths and incidence of severe infections. This study aimed to analyze the data from th

Externí odkaz: https://doaj.org/article/6dc0fa435835412099a962069329f0e1

Effectiveness and Safety of Golimumab in the Treatment of Ulcerative Colitis: 52-week Results from Post-marketing Surveillance in Japan

Autor: Shiro Nakamura, Teita Asano, Yoshihito Tanaka, Kanami Sugimoto, Shinichi Yoshigoe, Yasuo Suzuki

Publikováno v: Inflammatory Intestinal Diseases (2022)

Introduction: Real-world evidence for the effectiveness and safety of golimumab (GLM) in patients with ulcerative colitis (UC) is limited. The aim of this study was to investigate the 52-week effectiveness and safety of GLM treatment for UC. Methods:

Externí odkaz: https://doaj.org/article/41b73e39759c4bd9b4f987ad46c0f1e2

Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism

Autor: Avijite Kumer Sarkar, Shiro Nakamura, Kento Nakai, Taro Sato, Takahiro Shiga, Yuka Abe, Yurie Hoashi, Tomio Inoue, Wado Akamatsu, Kazuyoshi Baba

Publikováno v: Stem Cell Research, Vol 59, Iss , Pp 102658- (2022)

Sleep bruxism (SB) is a sleep-related movement disorder characterized by grinding and clenching of the teeth during sleep. We previously found a significant association between SB and a single nucleotide polymorphism (SNP), rs6313, in the neuronal se

Externí odkaz: https://doaj.org/article/c229fdb852f24dda82cebbd84c52c720