Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Shiro Mita"'
Publikováno v:
Nuclear Medicine and Biology. 39:1117-1121
Introduction The σ 1 ligands are considered to be a new class of potential therapeutic agents for several types of central nervous system disorder. Carbon-11-labeled 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine ([ 11 C]SA4503) was s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc44b0fc46ab67c8fa28d3ebaa288d88
https://doi.org/10.1016/j.nucmedbio.2012.06.004
https://doi.org/10.1016/j.nucmedbio.2012.06.004
Publikováno v:
Synapse. 66:630-639
The sigma-1 receptor (Sig-1R) is a novel endoplasmic reticulum (ER) molecular chaperone that regulates protein folding and degradation. The Sig-1R activation by agonists is known to improve memory, promote cell survival, and exert an antidepressant-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f6aad599f7403bda0aca5da1d8a540
https://doi.org/10.1002/syn.21549
https://doi.org/10.1002/syn.21549
Autor:
Fumio Tsuji, Minoru Sasano, Hiroshi Suhara, Masato Horiuchi, Kenji Oki, Takashi Yamanouchi, Shiro Mita, Akihiko Okahara
Publikováno v:
Cytokine. 17:294-300
We investigated the effects of marimastat, an inhibitor of TNF-alpha converting enzyme and matrix metalloproteinases, and anti-TNF-alpha antibodies on a murine model for sepsis, and on arthritis in human TNF-alpha transgenic mice. Marimastat (25-200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4affcf02e19d5f8d53a052944391d93
https://doi.org/10.1006/cyto.2002.1015
https://doi.org/10.1006/cyto.2002.1015
Autor:
David Školoudík, Shiro Mita, Hans J. Moebius, Keith W. Muir, Estevo Santamarina, Roman Urfer, Wakao Sato
Publikováno v:
Stroke. 45(11)
Background and Purpose— The σ-1 receptor (Sig-1R) agonist cutamesine (SA4503) enhanced functional recovery after experimental stroke with a treatment initiation window of 48 hours and chronic treatment for 28 days. We conducted a phase 2 clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb4f0aa807df07c1c957e3b6a32cffd
https://pubmed.ncbi.nlm.nih.gov/25270629
https://pubmed.ncbi.nlm.nih.gov/25270629
Autor:
Daisuke, Yamashita, Guang-wei, Sun, Yong, Cui, Shiro, Mita, Naoki, Otsuki, Sho, Kanzaki, Ken-ichi, Nibu, Kaoru, Ogawa, Tatsuo, Matsunaga
Publikováno v:
Journal of neuroscience research. 93(5)
The sigma-1 receptor, which is expressed throughout the brain, provides physiological benefits that include higher brain function. The sigma-1 receptor functions as a chaperone in the endoplasmic reticulum and may control cell death and regeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25ddabbe983e289991e0269e7df2cd5a
https://pubmed.ncbi.nlm.nih.gov/25612541
https://pubmed.ncbi.nlm.nih.gov/25612541
Autor:
Yosihiro Kinoshita, Shiro Mita, Kenichi P. Takahashi, Sachiyo Ichinose, Akira Omori, Akira Inoue
Publikováno v:
European Journal of Biochemistry. 268:3654-3663
S1 proteins A–D are liberated from thoroughly washednuclei by mild digestion with DNase I or RNase A, andextracted selectively at pH 4.9 from the reaction super-natants. Here, we characterized the S1 proteins, focusing onprotein D2, the most abunda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9541639ae808596e38ecc739ce639f
https://doi.org/10.1046/j.1432-1327.2001.02267.x
https://doi.org/10.1046/j.1432-1327.2001.02267.x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1545:146-152
A low molecular weight protein complexed with chymase was isolated from hamster cheek pouch tissues. This protein had an apparent molecular mass of about 10 kDa on SDS-PAGE and the N-terminal sequence showed some homology to secretory leukocyte prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e904fe8fbd16038e93a1b15853fefa0
https://doi.org/10.1016/s0167-4838(00)00272-7
https://doi.org/10.1016/s0167-4838(00)00272-7
Publikováno v:
Life Sciences. 67:599-603
Here we measured sigma receptor agonist, [3H](+)-pentazocine binding and (+)-pentazocine-stimulated [35S]GTPgammaS binding throughout brain regions and peripheral organs of mice and guinea pigs to investigate the distribution of G protein-coupled sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbd52f52463beb8e272f57cee3f6a6c
https://doi.org/10.1016/s0024-3205(00)00651-2
https://doi.org/10.1016/s0024-3205(00)00651-2
Autor:
Akira Yoshida, Kiyoshi Matsuno, Shogo Tokuyama, Hiroshi Ueda, Shiro Mita, Junko Maruo, Kinya Hirata
Publikováno v:
Neuroscience Letters. 268:85-88
Various sigma (sigma) ligands including (+)-pentazocine stimulated [35S]GTPgammaS binding in synaptic membranes from the mouse cerebellum. The (+)-pentazocine-stimulated [35S]GTPgammaS binding was blocked by the treatment of membranes with pertussis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdace9c1108693b5b5d4bbc4fb261b1a
https://doi.org/10.1016/s0304-3940(99)00387-0
https://doi.org/10.1016/s0304-3940(99)00387-0
Publikováno v:
Immunology Letters. 68:275-279
The effects of mitogen-activated protein (MAP) kinase inhibitors or phosphodiesterase (PDE) inhibitors on interleukin (IL)-1-induced cytokines production in synovium-derived cells were investigated. Human synoviocyte (HS) or synovial sarcoma (SW982)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a77225b1c5761e5e8f78c356485708e
https://doi.org/10.1016/s0165-2478(99)00051-6
https://doi.org/10.1016/s0165-2478(99)00051-6