Zobrazeno 1 - 10
of 489
pro vyhledávání: '"Shiro Ikegawa"'
Autor:
Shuji Ito, Hiroshi Takuwa, Saori Kakehi, Yuki Someya, Hideyoshi Kaga, Nobuyuki Kumahashi, Suguru Kuwata, Takuya Wakatsuki, Masaru Kadowaki, Soichiro Yamamoto, Takafumi Abe, Miwako Takeda, Yuki Ishikawa, Xiaoxi Liu, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Keiko Hikino, Kohei Tomizuka, Yukihide Momozawa, Kouichi Ozaki, Minoru Isomura, Toru Nabika, Haruka Kaneko, Muneaki Ishijima, Ryuzo Kawamori, Hirotaka Watada, Yoshifumi Tamura, Yuji Uchio, Shiro Ikegawa, Chikashi Terao
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (
Externí odkaz:
https://doaj.org/article/cd023cc995e649fbbe15c12e3ca897d0
Autor:
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, Masanari Kodera, Yuichiro Shirai, Mitsuteru Akahoshi, Minoru Hasegawa, Takashi Matsushita, Kazuyoshi Saito, Sei-ichiro Motegi, Hajime Yoshifuji, Ayumi Yoshizaki, Tomohiro Kohmoto, Kae Takagi, Akira Oka, Miho Kanda, Yoshihito Tanaka, Yumi Ito, Kazuhisa Nakano, Hiroshi Kasamatsu, Akira Utsunomiya, Akiko Sekiguchi, Hiroaki Niiro, Masatoshi Jinnin, Katsunari Makino, Takamitsu Makino, Hironobu Ihn, Motohisa Yamamoto, Chisako Suzuki, Hiroki Takahashi, Emi Nishida, Akimichi Morita, Toshiyuki Yamamoto, Manabu Fujimoto, Yuya Kondo, Daisuke Goto, Takayuki Sumida, Naho Ayuzawa, Hidetoshi Yanagida, Tetsuya Horita, Tatsuya Atsumi, Hirahito Endo, Yoshihito Shima, Atsushi Kumanogoh, Jun Hirata, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Kohei Tomizuka, Soichiro Yoshino, Xiaoxi Liu, Shuji Ito, Keiko Hikino, Akari Suzuki, Yukihide Momozawa, Shiro Ikegawa, Yoshiya Tanaka, Osamu Ishikawa, Kazuhiko Takehara, Takeshi Torii, Shinichi Sato, Yukinori Okada, Tsuneyo Mimori, Fumihiko Matsuda, Koichi Matsuda, Tiffany Amariuta, Issei Imoto, Keitaro Matsuo, Masataka Kuwana, Yasushi Kawaguchi, Koichiro Ohmura, Chikashi Terao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region,
Externí odkaz:
https://doaj.org/article/2821292baef747248e9e487cef06ad07
Autor:
Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, David D. Conti, Nao Otomo, Zsofia Kote-Jarai, Hiroyuki Suetsugu, Rosalind A. Eeles, Yoshinao Koike, Keiko Hikino, Soichiro Yoshino, Kohei Tomizuka, Momoko Horikoshi, Kaoru Ito, Yuji Uchio, Yukihide Momozawa, Michiaki Kubo, The BioBank Japan Project, Yoichiro Kamatani, Koichi Matsuda, Christopher A. Haiman, Shiro Ikegawa, Hidewaki Nakagawa, Chikashi Terao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Prostate cancer (PrCa) is the second most common cancer worldwide in males. While strongly warranted, the prediction of mortality risk due to PrCa, especially before its development, is challenging. Here, we address this issue by maximizing
Externí odkaz:
https://doaj.org/article/ee30aa5cf88e456e9ab064b3dd8991f6
Autor:
Yugo Morita, Yoichiro Kamatani, Hiromu Ito, Shiro Ikegawa, Takahisa Kawaguchi, Shuji Kawaguchi, Meiko Takahashi, Chikashi Terao, Shuji Ito, Kohei Nishitani, Shinichiro Nakamura, Shinichi Kuriyama, Yasuharu Tabara, Fumihiko Matsuda, Shuichi Matsuda, on behalf of the Nagahama study group
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Polygenic risk score (PRS) analysis is used to predict disease risk. Although PRS has been shown to have great potential in improving clinical care, PRS accuracy assessment has been mainly focused on European ancestry. This study
Externí odkaz:
https://doaj.org/article/f292ab102fa7457d919e69b469ff65ae
Autor:
Hao Yu, Anas M Khanshour, Aki Ushiki, Nao Otomo, Yoshinao Koike, Elisabet Einarsdottir, Yanhui Fan, Lilian Antunes, Yared H Kidane, Reuel Cornelia, Rory R Sheng, Yichi Zhang, Jimin Pei, Nick V Grishin, Bret M Evers, Jason Pui Yin Cheung, John A Herring, Chikashi Terao, You-qiang Song, Christina A Gurnett, Paul Gerdhem, Shiro Ikegawa, Jonathan J Rios, Nadav Ahituv, Carol A Wise
Publikováno v:
eLife, Vol 12 (2024)
Adolescent idiopathic scoliosis (AIS) is a common and progressive spinal deformity in children that exhibits striking sexual dimorphism, with girls at more than fivefold greater risk of severe disease compared to boys. Despite its medical impact, the
Externí odkaz:
https://doaj.org/article/008395c97b104a1f9a8bdc58a295796f
Autor:
Faegheh Ghanbari, Nao Otomo, Isabel Gamache, Takuro Iwami, Yoshinao Koike, Anas M. Khanshour, Shiro Ikegawa, Carol A. Wise, Chikashi Terao, Despoina Manousaki
Publikováno v:
JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)
ABSTRACT Adolescent idiopathic scoliosis (AIS) is the most common form of pediatric musculoskeletal disorder. Observational studies have pointed to several risk factors for AIS, but almost no evidence exists to support their causal association with A
Externí odkaz:
https://doaj.org/article/628ad1aeebe3444daf065537ed060858
Autor:
Yoshinao Koike, Masahiko Takahata, Masahiro Nakajima, Nao Otomo, Hiroyuki Suetsugu, Xiaoxi Liu, Tsutomu Endo, Shiro Imagama, Kazuyoshi Kobayashi, Takashi Kaito, Satoshi Kato, Yoshiharu Kawaguchi, Masahiro Kanayama, Hiroaki Sakai, Takashi Tsuji, Takeshi Miyamoto, Hiroyuki Inose, Toshitaka Yoshii, Masafumi Kashii, Hiroaki Nakashima, Kei Ando, Yuki Taniguchi, Kazuhiro Takeuchi, Shuji Ito, Kohei Tomizuka, Keiko Hikino, Yusuke Iwasaki, Yoichiro Kamatani, Shingo Maeda, Hideaki Nakajima, Kanji Mori, Atsushi Seichi, Shunsuke Fujibayashi, Tsukasa Kanchiku, Kei Watanabe, Toshihiro Tanaka, Kazunobu Kida, Sho Kobayashi, Masahito Takahashi, Kei Yamada, Hiroshi Takuwa, Hsing-Fang Lu, Shumpei Niida, Kouichi Ozaki, Yukihide Momozawa, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Masashi Yamazaki, Atsushi Okawa, Morio Matsumoto, Norimasa Iwasaki, Chikashi Terao, Shiro Ikegawa
Publikováno v:
eLife, Vol 12 (2023)
Ossification of the posterior longitudinal ligament of the spine (OPLL) is an intractable disease leading to severe neurological deficits. Its etiology and pathogenesis are primarily unknown. The relationship between OPLL and comorbidities, especiall
Externí odkaz:
https://doaj.org/article/eda7d0627866429283f54547e72b72f0
Autor:
Nao Otomo, Anas M. Khanshour, Masaru Koido, Kazuki Takeda, Yukihide Momozawa, Michiaki Kubo, Yoichiro Kamatani, John A. Herring, Yoji Ogura, Yohei Takahashi, Shohei Minami, Koki Uno, Noriaki Kawakami, Manabu Ito, Tatsuya Sato, Kei Watanabe, Takashi Kaito, Haruhisa Yanagida, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Hideki Shigematsu, Takahiro Iida, Satoru Demura, Ryo Sugawara, Nobuyuki Fujita, Mitsuru Yagi, Eijiro Okada, Naobumi Hosogane, Katsuki Kono, Masaya Nakamura, Kazuhiro Chiba, Toshiaki Kotani, Tsuyoshi Sakuma, Tsutomu Akazawa, Teppei Suzuki, Kotaro Nishida, Kenichiro Kakutani, Taichi Tsuji, Hideki Sudo, Akira Iwata, Satoshi Inami, Carol A. Wise, Yuta Kochi, Morio Matsumoto, Shiro Ikegawa, Kota Watanabe, Chikashi Terao
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionAdolescent idiopathic scoliosis (AIS) is a disorder with a three-dimensional spinal deformity and is a common disease affecting 1-5% of adolescents. AIS is also known as a complex disease involved in environmental and genetic factors. A r
Externí odkaz:
https://doaj.org/article/dc2885acc10e4fffb1300ea4789cc6bd
Autor:
Mehran Kausar, Noor Ul Ain, Farzana Hayat, Hunain Fatima, Saad Azim, Hazrat Ullah, Murva Mushtaq, Sumbal Khalid, Shahid Hussain, Sadaf Naz, Jamal Janjua, Saad Bin Amjad, Ruqia Mehmood Baig, Outi Makitie, Raheel Qamar, Shiro Ikegawa, Nishimura Gen, Chiea Chuen Khor, Jia Nee Foo, Saima Siddiqi
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-7 (2022)
Abstract Background Skeletal dysplasia is a heterogeneous group of disorders. Spondyloepiphyseal dysplasias comprise one subgroup. Deficiency of carbohydrate sulfotransferase 3 has been reported in a small number of patients with recessively inherite
Externí odkaz:
https://doaj.org/article/139e708906cd48b3870a0c41552da441
Autor:
Ziying Sun, Qianqian Liu, Zhongyang Lv, Jiawei Li, Xingquan Xu, Heng Sun, Maochun Wang, Kuoyang Sun, Tianshu Shi, Zizheng Liu, Guihua Tan, Wenqiang Yan, Rui Wu, Yannick Xiaofan Yang, Shiro Ikegawa, Qing Jiang, Yang Sun, Dongquan Shi
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 7, Pp 3073-3084 (2022)
Osteoarthritis (OA), in which M1 macrophage polarization in the synovium exacerbates disease progression, is a major cause of cartilage degeneration and functional disabilities. Therapeutic strategies of OA designed to interfere with the polarization
Externí odkaz:
https://doaj.org/article/bcd2bb86c0934dd0bdb813a53561cb5b