Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shirlynn Chen"'
Publikováno v:
AAPS PharmSciTech. 23(6)
Though oral drug delivery is the most preferred route of administration, there is high drug pharmacokinetic variability associated with the oral route. Change in drug substance particle size distribution, formulation composition, or manufacturing pro
Autor:
Andre Hermans, Kailas Thakker, Shirlynn Chen, Margareth Marques, Matthias G. Wacker, Changquan Calvin Sun, Sandra Klein, Sanjaykumar Patel, Tapash Ghosh, Hanlin Li, Justin Yong Soon Tay, Johannes Kraemer, Anne Seidlitz, Sarah Nielsen, Celine Valeria Liew, Przemysław Dorożyński, Christos Reppas, Katharina Pruessmann, Fernando J. Muzzio, Yang Yang, Paul Wan Sia Heng, Guenther Hochhaus, Daniel Willett
Publikováno v:
Dissolution Technologies. 27:52-70
Autor:
Naveen K. Thakral, Schwabe Robert J, Shirlynn Chen, Corinne Jankovsky, Laibin Luo, Eva Meister, Li Li
Publikováno v:
International journal of pharmaceutics. 600
This review focuses on options available to a pharmaceutical scientist to predict in vivo supersaturation and precipitation of poorly water-soluble drugs. As no single device or system can simulate the complex gastrointestinal environment, a combinat
Autor:
Shirlynn Chen, Kaushalkumar Dave, Corinne Jankovsky, Cecile Forness, Doris Baker, Paul E. Luner
Publikováno v:
AAPS PharmSciTech. 19:155-165
This study examined the use of focused beam reflectance measurement (FBRM) for qualitative and quantitative analysis of pharmaceutical suspensions with particular application to toxicology supply preparations for use in preclinical studies. Aqueous s
Autor:
Mayur Suryakant Dudhedia, Steven L. Krill, John A. Smoliga, Zeren Wang, Paul-James Jones, Toby Tamblyn, Richard T. Darrington, Shirlynn Chen
Publikováno v:
Journal of pharmaceutical sciences. 98(5)
This report describes the solubility properties of a poorly soluble drug-excipient complex in a lipid based formulation. Tipranavir (TPV) was used as the model drug and 1,3-dioctanoylglycerol (DOG) as the excipient. The TPV-DOG complex was prepared b
Autor:
Ian Potocki, Shirlynn Chen, Rosemarie Sellati, Patricia L. Reilly, Kei Kishimoto, Emeigh Jonathan Emilian, Gerald Nabozny, Robert Rothlein, Donghong A. Gao, Miao Clara K, Daniel R. Goldberg, Sorcek Ronald J, Daniel Kuzmich, Terence A. Kelly, Drané O'Brien, Deborah D. Jeanfavre, Charline Peng, and Stephen H. Norris, Kevin Chungeng Qian, Elizabeth Mainolfi, Wu Jiang-Ping, Joseph R. Woska, Jocelyn A. Gunn
Publikováno v:
Journal of medicinal chemistry. 47(22)
A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochemical and metabolic properties of BIRT377 (1, Figure 1), a previously reported hydantoin-based LFA-1 inh
Publikováno v:
Drug development and industrial pharmacy. 25(2)
The present paper describes the rheological properties of hydroxypropylcellulose (HPC) gels formulated in propylene glycol (PG), water, ethanol, and mixtures of these components. The effects of molecular weight, polymer concentration, and solvent com