Výsledky vyhledávání - "Shirley W.I. Siu"

Akademický článek

Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue

Autor: Haixin Qin, Weimin Zuo, Lilin Ge, Shirley W.I. Siu, Lei Wang, Xiaoling Chen, Chengbang Ma, Tianbao Chen, Mei Zhou, Zhijian Cao, Hang Fai Kwok

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2960-2972 (2023)

In the development and study of antimicrobial peptides (AMPs), researchers have kept a watchful eye on peptides from the brevinin family because of their extensive antimicrobial activities and anticancer potency. In this study, a novel brevinin pepti

Externí odkaz: https://doaj.org/article/fa01fb22bf4f43f4a917acd3b3aae77c

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Akademický článek

A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway

Autor: Ran Wei, Qiushuang Wu, Nana Ai, Lei Wang, Mei Zhou, Chris Shaw, Tianbao Chen, Richard Dequan Ye, Wei Ge, Shirley W.I. Siu, Hang Fai Kwok

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2664-2675 (2021)

Chromogranin A (CgA) is a hydrophilic glycoprotein released by post-ganglionic sympathetic neurons. CgA consists of a single peptide chain containing numerous paired basic residues, which are typical cleavage sites in prohormones to generate bioactiv

Externí odkaz: https://doaj.org/article/041f8410cb14409db8613759450a01cc

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Akademický článek

Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning

Autor: Jielu Yan, Pratiti Bhadra, Ang Li, Pooja Sethiya, Longguang Qin, Hio Kuan Tai, Koon Ho Wong, Shirley W.I. Siu

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 882-894 (2020)

Antimicrobial peptides (AMPs) are a valuable source of antimicrobial agents and a potential solution to the multi-drug resistance problem. In particular, short-length AMPs have been shown to have enhanced antimicrobial activities, higher stability, a

Externí odkaz: https://doaj.org/article/0ff5c55c71b748bfbd1d9a85d487f6b9

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Akademický článek

In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide

Autor: Rui Ma, Sin Wa Wong, Lilin Ge, Chris Shaw, Shirley W.I. Siu, Hang Fai Kwok

Publikováno v: Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 7-19 (2020)

Although the physicochemical properties of antimicrobial peptides (AMPs) and anticancer peptides (ACPs) are very similar, it remains unclear which specific parameter(s) of ACPs confer the major anticancer activity. By answering how to construct a sho

Externí odkaz: https://doaj.org/article/beb78dbf3bed44a09d55f1fee5edbd06

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Multi-Branch-CNN: Classification of ion channel interacting peptides using multi-branch convolutional neural network

Autor: Jielu Yan, Bob Zhang, Mingliang Zhou, Hang Fai Kwok, Shirley W.I. Siu

Publikováno v: Computers in biology and medicine. 147

Ligand peptides that have high affinity for ion channels are critical for regulating ion flux across the plasma membrane. These peptides are now being considered as potential drug candidates for many diseases, such as cardiovascular disease and cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34d3b8449d32692fd76660d094b1cf3
https://pubmed.ncbi.nlm.nih.gov/35752114

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