Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Shirley S. Chan"'
Autor:
Robert H. Austin, Shirley S. Chan
Publikováno v:
Biochemical and Biophysical Research Communications. 312:215-221
Although proteins perform a vast multitude of tasks in living organisms, perhaps the most fascinating and least well understood is the nanoengine aspect of protein action, where chemical energy is turned into mechanical motion. In order for this to h
Autor:
Chia-Fu Chou, Olgica Bakajin, Shirley S. Chan, Robert H. Austin, Edward C. Cox, Jonas O. Tegenfeldt, N. Darnton, Thomas Duke
Publikováno v:
Biophysical Journal. 83:2170-2179
Dielectrophoretic trapping of molecules is typically carried out using metal electrodes to provide high field gradients. In this paper we demonstrate dielectrophoretic trapping using insulating constrictions at far lower frequencies than are feasible
Autor:
Olgica Bakajin, Jonas O. Tegenfeldt, Shirley S. Chan, Thomas Duke, Robert H. Austin, Edward C. Cox, Chia-Fu Chou
Publikováno v:
Analytical Chemistry. 73:6053-6056
Long double-stranded DNA molecules were separated in microfabricated hexagonal arrays in less than 1 min, several orders of magnitude faster than by using conventional technology. DNA samples were first concentrated at the entrance to the array in a
Autor:
Richard H. Ebright, Yon W. Ebright, Richard D. Ludescher, Achillefs N. Kapanidis, Shirley S. Chan
Publikováno v:
Journal of Molecular Biology. 312:453-468
In order to define the mean DNA bend angle and distribution of DNA bend angles in the catabolite activator protein (CAP)-DNA complex in solution under standard transcription initiation conditions, we have performed nanosecond time-resolved fluorescen
Autor:
Olgica Bakajin, Edward C. Cox, Shirley S. Chan, Thomas Duke, Robert H. Austin, Judith Castelino, N. Darnton, Chia-Fu Chou, Harold G. Craighead, Jongyoon Han, Jonas O. Tegenfeldt, Steve Turner
Publikováno v:
ELECTROPHORESIS. 21:81-90
Micro- and nanofabrication techniques have provided an unprecedented opportunity to create a designed world in which separation and fractionation technologies which normally occur on the macroscopic scale can be optimized by designing structures whic
Publikováno v:
Physical Review Letters. 80:2737-2740
The effect of confinement on the dynamics of polymers was studied by observing the transient extension and relaxation of single DNA molecules as they interacted with obstacles in a specially designed thin slit. Viscous drag was found to increase with
Publikováno v:
Biomedical Microdevices. 1:39-47
We demonstrate a novel activation behavior of human leucocyte adhesion under physiological flow conditions in a microfabricated silicon array of channels with length scales similar to those of human capillaries. Vital nuclei stains and cell specific,
Autor:
Robert H. Austin, Robert H. Carlson, Shirley S. Chan, James P. Brody, James W. Winkelman, Christopher V. Gabel
Publikováno v:
Physical Review Letters. 79:2149-2152
When a drop of human blood containing red and white blood cells is forced to move via hydrodynamic forces in a lattice of channels designed to mimic the capillary channels, the white cells self-fractionate into the different types of white cells. The
Publikováno v:
Electrophoresis. 17:1075-1079
Transverse pulsed-field electrophoresis of DNA has been conducted in a silicon array engineered by optical lithography and the motion of individual molecules observed by fluorescence microscopy. In strong fields, the molecules can be maintained in hi
Publikováno v:
Biological and Medical Physics, Biomedical Engineering ISBN: 9781441910431
The Physics of Proteins
The Physics of Proteins
Physics and the life sciences have established new connections within the past few decades, resulting in biological physics as an established subfield with strong groups working in many physics departments. These interactions between physics and biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61058304153235cb687b34d9a89c17c2
http://cds.cern.ch/record/1339145
http://cds.cern.ch/record/1339145