Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shirley M.-H. Sy"'
Autor:
Xin Yi Tan, Junshi Li, Justin W.C. Leung, Kirk West, Cheng-han Yu, Shirley M.-H. Sy, Chao Dong, Toyotaka Ishibashi, Michael S.Y. Huen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cells avoid clashes between DNA repair machineries and the transcription apparatus by temporary halting gene expression in the vicinity of DNA double-strand breaks (DSBs), an emerging DNA damage response (DDR) that underlies genome integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1647dde131a2ddbc25874e534f12afa3
https://doi.org/10.1073/pnas.2002193117
https://doi.org/10.1073/pnas.2002193117
Publikováno v:
Translational Oncology, Vol 13, Iss 9, Pp 100796-(2020)
Translational Oncology
Translational Oncology
Degree of genomic instability closely correlates with poor prognosis, drug resistance as well as poor survival across human cancer of different origins. This study assessed the relationship between DNA damage response (DDR) and chromosome instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1a21d0d9964690d898f55b1571db2f
https://doi.org/10.1016/j.tranon.2020.100796
https://doi.org/10.1016/j.tranon.2020.100796
Publikováno v:
Journal of Biological Chemistry. 290:27545-27556
The Fanconi anemia protein PALB2, also known as FANCN, protects genome integrity by regulating DNA repair and cell cycle checkpoints. Exactly how PALB2 functions may be temporally coupled with detection and signaling of DNA damage is not known. Intri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0c50be35efed37db24cb74804a6819
https://doi.org/10.1074/jbc.m115.672626
https://doi.org/10.1074/jbc.m115.672626
Protein ubiquitination has emerged as a pivotal regulatory reaction that promotes cellular responses to DNA damage. With a goal to delineate the DNA damage signal transduction cascade, we systematically analyzed the human E2 ubiquitin- and ubiquitin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dc195b5097fec38fbf230954ccad65
https://europepmc.org/articles/PMC5247668/
https://europepmc.org/articles/PMC5247668/
Autor:
Sui Sui Dong, Jun Huang, Yiqun Deng, Hua Cai, Shirley M.-H. Sy, Junjie Chen, Enoch S.L. Yeung, Gabriel Tsz Mei Lok, Jun Jiang, Michael S.Y. Huen, Jun Wu
Publikováno v:
Journal of Biological Chemistry. 286:22355-22361
Histone ubiquitylation is emerging as an important protective component in cellular responses to DNA damage. The ubiquitin ligases RNF8 and RNF168 assemble ubiquitin chains onto histone molecules surrounding DNA breaks and facilitate retention of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f32eff4d31756e9216fcc55d49c6f5e
https://doi.org/10.1074/jbc.m111.232041
https://doi.org/10.1074/jbc.m111.232041
Autor:
Edward H. Egelman, Michal Hammel, Gareth J. Williams, Dorina Saro, Julia Etchin, Shirley M.-H. Sy, David Schild, Dongqing Liu, Vitold E. Galkin, Patrick Sung, Xiong Yu, Junjie Chen, Claudia Wiese, Eloise Dray, Miaw-Sheue Tsai
Publikováno v:
Nature structural & molecular biology
Homologous recombination mediated by RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-strand breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and PALB2 act together to del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8bc3b92f896401abe8bd63fd85be72
http://europepmc.org/articles/PMC2950913
http://europepmc.org/articles/PMC2950913
Autor:
Michael S.Y. Huen, Sai Wah Tsao, Jun Huang, Yick-Pang Ching, Junjie Chen, Justin W.C. Leung, Shirley M.-H. Sy, Ka Man Leung
Publikováno v:
Molecular Cell. 37(6):854-864
Dynamic changes of chromatin structure facilitate diverse biological events, including DNA replication, repair, recombination, and gene transcription. Recent evidence revealed that DNA damage elicits alterations to the chromatin to facilitate proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46438e21f23d56e228cf0a20a605ce52
Publikováno v:
Nature Reviews Molecular Cell Biology. 11:138-148
The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32858f91c497a83b137b0864a657cc9
https://doi.org/10.1038/nrm2831
https://doi.org/10.1038/nrm2831
Publikováno v:
Journal of Biological Chemistry. 284:21127-21131
PALB2 is an integral component of the BRCA complex important for recombinational DNA repair. However, exactly how this activity is regulated in vivo remains unexplored. Here we provide evidefice to show that MRG15 is a novel PALB2-associated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050c99dbacea2d5a53ed29866f14fc27
https://doi.org/10.1074/jbc.c109.023937
https://doi.org/10.1074/jbc.c109.023937
Publikováno v:
Journal of Biological Chemistry. 284:12998-13003
Proper activation of checkpoint during mitotic stress is an important mechanism to prevent genomic instability. Chfr (Check point protein with FHA (Forkhead-associated domain) and RING domains) is a ubiquitin-protein isopeptide ligase (E3) that is im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b08c9814f71796223681e14b180df59
https://doi.org/10.1074/jbc.m900333200
https://doi.org/10.1074/jbc.m900333200