Diverse modes of binding in structures of Leishmania majorN-myristoyltransferase with selective inhibitors

Autor: James A. Brannigan, Shirley M. Roberts, Andrew S. Bell, Jennie A. Hutton, Michael R. Hodgkinson, Edward W. Tate, Robin J. Leatherbarrow, Deborah F. Smith, Anthony J. Wilkinson

Publikováno v: IUCrJ, Vol 1, Iss 4, Pp 250-260 (2014)

The leishmaniases are a spectrum of global diseases of poverty associated with immune dysfunction and are the cause of high morbidity. Despite the long history of these diseases, no effective vaccine is available and the currently used drugs are vari

Externí odkaz: https://doaj.org/article/0ddbe1c7f7b94b29aa4a10083708bb2c

Degradation of phytate by the 6-phytase from Hafnia alvei: a combined structural and solution study.

Autor: Antonio Ariza, Olga V Moroz, Elena V Blagova, Johan P Turkenburg, Jitka Waterman, Shirley M Roberts, Jesper Vind, Carsten Sjøholm, Søren F Lassen, Leonardo De Maria, Vibe Glitsoe, Lars K Skov, Keith S Wilson

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e65062 (2013)

Phytases hydrolyse phytate (myo-inositol hexakisphosphate), the principal form of phosphate stored in plant seeds to produce phosphate and lower phosphorylated myo-inositols. They are used extensively in the feed industry, and have been characterised

Externí odkaz: https://doaj.org/article/da6a04667d9d4486b1d2bc7fcd758018

The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

Autor: Min Yang, Shirley M. Roberts, David N. Bolam, Benjamin G. Davis, Harry J. Gilbert, Gideon J. Davies, Eleanor J. Dodson, Mark R. Proctor, Johan P. Turkenburg, Carlos Martinez-Fleites

Glycosylation of macrolide antibiotics confers host cell immunity from endogenous and exogenous agents. The Streptomyces antibioticus glycosyltransferases, OleI and OleD, glycosylate and inactivate oleandomycin and diverse macrolides including erythr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e38cbf1d1d8f254bcff8e577dcecf4
https://doi.org/10.1073/pnas.0607897104

Total Syntheses of Casuarine and Its 6-O-α-Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families

Autor: Shirley M. Roberts, Andrea Goti, Francesca Cardona, Lyann Sim, Camilla Parmeggiani, Claudia Bonaccini, Gideon J. Davies, Tracey M. Gloster, Paola Gratteri, Enrico Faggi, David R. Rose

Publikováno v: Chemistry - A European Journal. 15:1627-1636

Total synthesis of naturally occurring casuarine (1) and the first total synthesis of casuarine 6-O-alpha-glucoside (2) were achieved through complete stereoselective nitrone cycloaddition, Tamao-Fleming oxidation and selective alpha-glucosylation as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a462321fa378c20e0ed09e078882247
https://doi.org/10.1002/chem.200801578

Structural Studies of the β-Glycosidase from Sulfolobus solfataricus in Complex with Covalently and Noncovalently Bound Inhibitors

Autor: Mosè Rossi, Shirley M. Roberts, Gideon J. Davies, Valérie M.-A. Ducros, Giuseppe Perugino, Marco Moracci, Roland Hoos, Tracey M. Gloster, and Andrea Vasella

Publikováno v: Biochemistry (Easton) 43 (2004): 6101–6109. doi:10.1021/bi049666m
info:cnr-pdr/source/autori:Gloster T.M.; Roberts S.; Ducros V.M.; Perugino G.; Rossi M.; Hoos R.; Moracci M.; Vasella A.; Davies G.J./titolo:Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors/doi:10.1021%2Fbi049666m/rivista:Biochemistry (Easton)/anno:2004/pagina_da:6101/pagina_a:6109/intervallo_pagine:6101–6109/volume:43

Transition-state mimicry is increasingly important both to understand enzyme mechanism and to direct the synthesis of putative therapeutic agents. X-ray crystallography is able to provide vital information on the interactions between an enzyme and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fed382b5510377ba722ece9ab6d6e6
https://doi.org/10.1021/bi049666m