Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Shirley M Roberts"'
Degradation of phytate by the 6-phytase from Hafnia alvei: a combined structural and solution study.
Autor:
Antonio Ariza, Olga V Moroz, Elena V Blagova, Johan P Turkenburg, Jitka Waterman, Shirley M Roberts, Jesper Vind, Carsten Sjøholm, Søren F Lassen, Leonardo De Maria, Vibe Glitsoe, Lars K Skov, Keith S Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65062 (2013)
Phytases hydrolyse phytate (myo-inositol hexakisphosphate), the principal form of phosphate stored in plant seeds to produce phosphate and lower phosphorylated myo-inositols. They are used extensively in the feed industry, and have been characterised
Externí odkaz:
https://doaj.org/article/da6a04667d9d4486b1d2bc7fcd758018
Autor:
James A. Brannigan, Shirley M. Roberts, Andrew S. Bell, Jennie A. Hutton, Michael R. Hodgkinson, Edward W. Tate, Robin J. Leatherbarrow, Deborah F. Smith, Anthony J. Wilkinson
Publikováno v:
IUCrJ, Vol 1, Iss 4, Pp 250-260 (2014)
The leishmaniases are a spectrum of global diseases of poverty associated with immune dysfunction and are the cause of high morbidity. Despite the long history of these diseases, no effective vaccine is available and the currently used drugs are vari
Externí odkaz:
https://doaj.org/article/0ddbe1c7f7b94b29aa4a10083708bb2c
Autor:
Gavin H. Thomas, Roderick E. Hubbard, Marcus Fischer, Johan P. Turkenburg, Shirley M. Roberts, Adam P. Hopkins, James A. Brannigan, John F. Darby, Seishi Shimizu
Publikováno v:
Journal of the American Chemical Society. 141:15818-15826
Solvent organization is a key but underexploited contributor to the thermodynamics of protein-ligand recognition, with implications for ligand discovery, drug resistance, and protein engineering. Here, we explore the contribution of solvent to ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7dff8fc3ae51a461a0aedb66a2bd14
https://doi.org/10.1021/jacs.9b06275
https://doi.org/10.1021/jacs.9b06275
Autor:
Z. Yu, Shirley M. Roberts, J.A. Hutton, James A. Brannigan, Andrew Simon Bell, Robin J. Leatherbarrow, Daniel Paape, Anthony J. Wilkinson, Megan H. Wright, Charlotte L. Sutherell, Edward W. Tate, Markus Ritzefeld, Deborah F. Smith
Publikováno v:
Journal of Medicinal Chemistry
The leishmaniases, caused by Leishmania species of protozoan parasites, are neglected tropical diseases with millions of cases worldwide. Current therapeutic approaches are limited by toxicity, resistance, and cost. N-Myristoyltransferase (NMT), an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9f2666a304fae6a1cac6032c4a5f81
http://hdl.handle.net/10044/1/80204
http://hdl.handle.net/10044/1/80204
Autor:
Vibe Glitsoe, Jitka Waterman, Lars K. Skov, Shirley M. Roberts, Leonardo De Maria, Keith S. Wilson, Antonio Ariza, Olga V. Moroz, Carsten Sjøholm, Jesper Vind, Johan P. Turkenburg, Søren Flensted Lassen, Elena Blagova
Publikováno v:
PLoS ONE
'PloS One ', vol: 8, pages: e65062-1-e65062-13 (2013)
PLoS ONE, Vol 8, Iss 5, p e65062 (2013)
'PloS One ', vol: 8, pages: e65062-1-e65062-13 (2013)
PLoS ONE, Vol 8, Iss 5, p e65062 (2013)
Phytases hydrolyse phytate (myo-inositol hexakisphosphate), the principal form of phosphate stored in plant seeds to produce phosphate and lower phosphorylated myo-inositols. They are used extensively in the feed industry, and have been characterised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9770d81c0505806a94cac0ec739e8229
https://doi.org/10.1371/journal.pone.0065062
https://doi.org/10.1371/journal.pone.0065062
Autor:
Min Yang, Shirley M. Roberts, David N. Bolam, Benjamin G. Davis, Harry J. Gilbert, Gideon J. Davies, Eleanor J. Dodson, Mark R. Proctor, Johan P. Turkenburg, Carlos Martinez-Fleites
Glycosylation of macrolide antibiotics confers host cell immunity from endogenous and exogenous agents. The Streptomyces antibioticus glycosyltransferases, OleI and OleD, glycosylate and inactivate oleandomycin and diverse macrolides including erythr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e38cbf1d1d8f254bcff8e577dcecf4
https://doi.org/10.1073/pnas.0607897104
https://doi.org/10.1073/pnas.0607897104
Autor:
Jens M. Eklöf, Werner Besenmatter, Keith S. Wilson, Shirley M. Roberts, Antonio Ariza, Michael Skjøt, Gideon J. Davies, Wendy A. Offen, Harry Brumer, Esben Peter Friis, Oliver Spadiut
Publikováno v:
The Journal of Biological Chemistry
The enzymatic degradation of plant polysaccharides is emerging as one of the key environmental goals of the early 21st century, impacting on many processes in the textile and detergent industries as well as biomass conversion to biofuels. One of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df840588b340cf4fc720aaa11b94d189
http://europepmc.org/articles/PMC3190823
http://europepmc.org/articles/PMC3190823
Autor:
Shirley M. Roberts, Andrea Goti, Francesca Cardona, Lyann Sim, Camilla Parmeggiani, Claudia Bonaccini, Gideon J. Davies, Tracey M. Gloster, Paola Gratteri, Enrico Faggi, David R. Rose
Publikováno v:
Chemistry - A European Journal. 15:1627-1636
Total synthesis of naturally occurring casuarine (1) and the first total synthesis of casuarine 6-O-alpha-glucoside (2) were achieved through complete stereoselective nitrone cycloaddition, Tamao-Fleming oxidation and selective alpha-glucosylation as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a462321fa378c20e0ed09e078882247
https://doi.org/10.1002/chem.200801578
https://doi.org/10.1002/chem.200801578
Autor:
Jon, Agirre, Antonio, Ariza, Wendy A, Offen, Johan P, Turkenburg, Shirley M, Roberts, Stuart, McNicholas, Paul V, Harris, Brett, McBrayer, Jan, Dohnalek, Kevin D, Cowtan, Gideon J, Davies, Keith S, Wilson
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The three-dimensional structures of two industrially important family GH3 β-d-glucosidases from A. fumigatus and A. oryzae are reported at 1.95 Å resolution. Both enzymes show extensive N-glycosylation. The extensive glycans pose special problems f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6cec2b6472613d40b55c29a4334e181
https://pubmed.ncbi.nlm.nih.gov/26894673
https://pubmed.ncbi.nlm.nih.gov/26894673
Autor:
Mosè Rossi, Shirley M. Roberts, Gideon J. Davies, Valérie M.-A. Ducros, Giuseppe Perugino, Marco Moracci, Roland Hoos, Tracey M. Gloster, and Andrea Vasella
Publikováno v:
Biochemistry (Easton) 43 (2004): 6101–6109. doi:10.1021/bi049666m
info:cnr-pdr/source/autori:Gloster T.M.; Roberts S.; Ducros V.M.; Perugino G.; Rossi M.; Hoos R.; Moracci M.; Vasella A.; Davies G.J./titolo:Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors/doi:10.1021%2Fbi049666m/rivista:Biochemistry (Easton)/anno:2004/pagina_da:6101/pagina_a:6109/intervallo_pagine:6101–6109/volume:43
info:cnr-pdr/source/autori:Gloster T.M.; Roberts S.; Ducros V.M.; Perugino G.; Rossi M.; Hoos R.; Moracci M.; Vasella A.; Davies G.J./titolo:Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors/doi:10.1021%2Fbi049666m/rivista:Biochemistry (Easton)/anno:2004/pagina_da:6101/pagina_a:6109/intervallo_pagine:6101–6109/volume:43
Transition-state mimicry is increasingly important both to understand enzyme mechanism and to direct the synthesis of putative therapeutic agents. X-ray crystallography is able to provide vital information on the interactions between an enzyme and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fed382b5510377ba722ece9ab6d6e6
https://doi.org/10.1021/bi049666m
https://doi.org/10.1021/bi049666m