Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Shirley L Zhang"'
Autor:
Jessica E Schwarz, Antonijo Mrčela, Nicholas F Lahens, Yongjun Li, Cynthia Hsu, Gregory R Grant, Carsten Skarke, Shirley L Zhang, Amita Sehgal
Publikováno v:
eLife, Vol 12 (2024)
Aging is associated with a number of physiologic changes including perturbed circadian rhythms; however, mechanisms by which rhythms are altered remain unknown. To test the idea that circulating factors mediate age-dependent changes in peripheral rhy
Externí odkaz:
https://doaj.org/article/127454988c634a1f8e230534ab8e4214
Publikováno v:
eLife, Vol 12 (2023)
Steroid hormones are attractive candidates for transmitting long-range signals to affect behavior. These lipid-soluble molecules derived from dietary cholesterol easily penetrate the brain and act through nuclear hormone receptors (NHRs) that functio
Externí odkaz:
https://doaj.org/article/3a9f4008bb3045a3bfec3dbd5841a7de
Publikováno v:
eLife, Vol 7 (2018)
Glia are important modulators of neural activity, yet few studies link glia to sleep regulation. We find that blocking activity of the endocytosis protein, dynamin, in adult Drosophila glia increases sleep and enhances sleep need, manifest as resista
Externí odkaz:
https://doaj.org/article/a27b4d00021a40edb2881d8e5e41838c
Autor:
Shirley L. Zhang, Nicholas F. Lahens, Zhifeng Yue, Denice M. Arnold, Peter P. Pakstis, Jessica E. Schwarz, Amita Sehgal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The blood-brain barrier is critical for neural function. Here, the authors show that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells.
Externí odkaz:
https://doaj.org/article/a7136728c6604f689f9ba94c54ccf6b6
Autor:
Shaon Sengupta, Soon Y. Tang, Jill C. Devine, Seán T. Anderson, Soumyashant Nayak, Shirley L. Zhang, Alex Valenzuela, Devin G. Fisher, Gregory R. Grant, Carolina B. López, Garret A. FitzGerald
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The circadian clock affects immune responses, but its role in influenza infection is not well understood. Here, Sengupta et al. show that time of infection and the circadian clock have no effect on lung virus titers, but affect inflammation, morbidit
Externí odkaz:
https://doaj.org/article/dfd0fc631a7044e1aeeb24d20b853a8f
Autor:
Jessica E. Schwarz, Antonijo Mrčela, Nicholas F. Lahens, Yongjun Li, Cynthia T. Hsu, Gregory Grant, Carsten Skarke, Shirley L. Zhang, Amita Sehgal
Aging is associated with a number of physiologic changes including perturbed circadian rhythms; however, mechanisms by which rhythms are altered remain unknown. To test the idea that circulating factors mediate age-dependent changes in peripheral rhy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d97b4377963d2b7c7b6be8b102fce53d
https://doi.org/10.1101/2023.04.19.537477
https://doi.org/10.1101/2023.04.19.537477
Publikováno v:
Trends Neurosci
The blood-brain barrier (BBB) is an evolutionarily conserved, structural, and functional separation between circulating blood and the central nervous system (CNS). By controlling permeability into and out of the nervous system, the BBB has a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e453cc18cd90749580a7721534eee0
https://doi.org/10.1016/j.tins.2019.05.001
https://doi.org/10.1016/j.tins.2019.05.001
Autor:
Chi V. Dang, Joy Shon, Amita Sehgal, Dechun Chen, Yool Lee, Nicholas F. Lahens, Shi Yi Fong, Jeffrey Field, Rebekah C. Brooks, Shirley L. Zhang
Publikováno v:
Science Advances
Circadian regulation of tumors provides a basis for chemotherapy at specific times of day.
Circadian rhythms are an integral part of physiology, underscoring their relevance for the treatment of disease. We conducted cell-based high-throughput s
Circadian rhythms are an integral part of physiology, underscoring their relevance for the treatment of disease. We conducted cell-based high-throughput s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb5fa9058526f37f974422278f581d5
http://europepmc.org/articles/PMC7880601
http://europepmc.org/articles/PMC7880601
Autor:
Nicholas F. Lahens, Denice M. Arnold, Shirley L. Zhang, Amita Sehgal, Peter P. Pakstis, Zhifeng Yue, Jessica Schwarz
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The blood-brain barrier (BBB) is critical for neural function. We report here circadian regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with highest levels during the active phase and lowest during the resting p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769dcc830db0f965160f02e4f0605c1d
http://europepmc.org/articles/PMC7841146
http://europepmc.org/articles/PMC7841146