Zobrazeno 1 - 10
of 1 811
pro vyhledávání: '"Shirley K"'
Autor:
Karthik Venkatakrishnan, Priya Jayachandran, Shirley K. Seo, Piet H. van derGraaf, John A. Wagner, Neeraj Gupta
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 6, Pp 909-918 (2024)
Externí odkaz:
https://doaj.org/article/e567e87ebda9452789fe3976798465d2
Autor:
Neda Rafieiolhosseini, Matthias Killa, Thorben Neumann, Niklas Tötsch, Jean-Noël Grad, Alexander Höing, Thies Dirksmeyer, Jochen Niemeyer, Christian Ottmann, Shirley K. Knauer, Michael Giese, Jens Voskuhl, Daniel Hoffmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1322-1331 (2022)
The 14-3-3 protein family, one of the first discovered phosphoserine/phosphothreonine binding proteins, has attracted interest not only because of its important role in the cell regulatory processes but also due to its enormous number of interactions
Externí odkaz:
https://doaj.org/article/d60fc9a2fd0f4a07b702ee811fd82535
Autor:
Shirley C. W. Chan, Yong-Fei Wang, Desmond Y. H. Yap, Tak Mao Chan, Yu Lung Lau, Pamela P. W. Lee, Wai Ming Lai, Shirley K. Y. Ying, Niko K. C. Tse, Alexander M. H. Leung, Chi Chiu Mok, Ka Lai Lee, Teresa W. L. Li, Helen H. L. Tsang, Winnie W. Y. Yeung, Carmen T. K. Ho, Raymond W. S. Wong, Wanling Yang, Chak Sing Lau, Philip H. Li
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectivesLupus nephritis (LN) remains one of the most severe manifestations in patients with systemic lupus erythematosus (SLE). Onset and overall LN risk among SLE patients remains considerably difficult to predict. Utilizing a territory-wide longi
Externí odkaz:
https://doaj.org/article/efd20347ad69459b8b64534448bec5e2
Autor:
Tim Rick, Vanessa Kreiling, Alexander Höing, Svenja Fiedler, Timo Glatter, Wieland Steinchen, Georg Hochberg, Heike Bähre, Roland Seifert, Gert Bange, Shirley K. Knauer, Peter L. Graumann, Kai M. Thormann
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract In bacteria, the monopolar localization of enzymes and protein complexes can result in a bimodal distribution of enzyme activity between the dividing cells and heterogeneity of cellular behaviors. In Shewanella putrefaciens, the multidomain
Externí odkaz:
https://doaj.org/article/b0a30200274b4b3fb7c321c53bb06cbe
Autor:
Christina Breder-Bonk, Dominic Docter, Matthias Barz, Sebastian Strieth, Shirley K. Knauer, Désirée Gül, Roland H. Stauber
Publikováno v:
Nanomaterials, Vol 13, Iss 18, p 2546 (2023)
Exposure to nanoparticles is inevitable as they become widely used in industry, cosmetics, and foods. However, knowledge of their (patho)physiological effects on biological entry routes of the human body and their underlying molecular mechanisms is s
Externí odkaz:
https://doaj.org/article/959508a8fd9145a1864da699a77efff9
Autor:
Astrid Hensel, Paul Stahl, Lisa Moews, Lena König, Rutuja Patwardhan, Alexander Höing, Nina Schulze, Perihan Nalbant, Roland H. Stauber, Shirley K. Knauer
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104355- (2022)
Summary: The unique threonine protease Tasp1 impacts not only ordered development and cell proliferation but also pathologies. However, its substrates and the underlying molecular mechanisms remain poorly understood. We demonstrate that the unconvent
Externí odkaz:
https://doaj.org/article/aa24896ee8034a1982f47721b9ec1424
Autor:
David Marks, Natalie Heinen, Lisa Bachmann, Sophia Meermeyer, Michelle Werner, Lucia Gallego, Peter Hemmerich, Verian Bader, Konstanze F. Winklhofer, Elisabeth Schröder, Shirley K. Knauer, Thorsten Müller
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract The amyloid precursor protein (APP) is a type I transmembrane protein with unknown physiological function but potential impact in neurodegeneration. The current study demonstrates that APP signals to the nucleus causing the generation of agg
Externí odkaz:
https://doaj.org/article/3bde9ac885af4675b505ae599942c36d
Autor:
Annika Meiners, Sandra Bäcker, Inesa Hadrović, Christian Heid, Christine Beuck, Yasser B. Ruiz-Blanco, Joel Mieres-Perez, Marius Pörschke, Jean-Noël Grad, Cecilia Vallet, Daniel Hoffmann, Peter Bayer, Elsa Sánchez-García, Thomas Schrader, Shirley K. Knauer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export sig
Externí odkaz:
https://doaj.org/article/57a8962dc1a04df6ae79162b6fd9c226
Autor:
Laura Koll, Désirée Gül, Manal I. Elnouaem, Hanaa Raslan, Omneya R. Ramadan, Shirley K. Knauer, Sebastian Strieth, Jan Hagemann, Roland H. Stauber, Aya Khamis
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4675 (2023)
Vitamin D (VitD) and its receptor (VDR) have been intensively investigated in many cancers. As knowledge for head and neck cancer (HNC) is limited, we investigated the (pre)clinical and therapeutic relevance of the VDR/VitD-axis. We found that VDR wa
Externí odkaz:
https://doaj.org/article/0f985e3d619248ecb747ff5369c9c03f
Autor:
Lisa Oelschläger, Paul Stahl, Farnusch Kaschani, Roland H. Stauber, Shirley K. Knauer, Astrid Hensel
Publikováno v:
Cells, Vol 12, Iss 3, p 363 (2023)
The human protease Taspase1 plays a pivotal role in developmental processes and cancerous diseases by processing critical regulators, such as the leukemia proto-oncoprotein MLL. Despite almost two decades of intense research, Taspase1’s biology is,
Externí odkaz:
https://doaj.org/article/49ea6af74a9d45459f84980616ea7e7d