Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shirley Jusino"'
Autor:
Shirley Jusino, Yainyrette Rivera-Rivera, Camille Chardón-Colón, Patricia C. Rodríguez-Rodríguez, Janeishly Román-González, Valeria S. Juliá-Hernández, Angel Isidro, Qianxing Mo, Harold I. Saavedra
Publikováno v:
Cell Division, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background Triple-negative breast cancer (TBNC) is an aggressive breast cancer subtype with a poor prognosis. Shugoshin-1 (SGO1) protects chromatids from early separation. Previous studies from our group have demonstrated that transient SGO1
Externí odkaz:
https://doaj.org/article/a3fd9f91da8f45a9944d91c1d16c0a87
Autor:
Yainyrette Rivera-Rivera, Mihaela Marina, Shirley Jusino, Miyoung Lee, Jaleisha Vélez Velázquez, Camille Chardón-Colón, Geraldine Vargas, Jaya Padmanabhan, Srikumar P. Chellappan, Harold I. Saavedra
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to centrosomes and kinetochores, controlling centrosome separation, chromosome attachments to kinetochores, and the spindle assembly checkpoint. These process
Externí odkaz:
https://doaj.org/article/349186be6236452795f3845aa7cf9050
Systematic review of the management of brain metastases from hormone receptor positive breast cancer
Publikováno v:
Journal of Neuro-Oncology. 162:45-57
Introduction Brain metastases are a common cause of morbidity and mortality in patients with breast cancer. Local central nervous system (CNS) directed therapies are usually the first line treatment for breast cancer brain metastases (BCBM), but thos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da40ad6ca758d2281e494a28e3f3127a
https://doi.org/10.1007/s11060-023-04276-9
https://doi.org/10.1007/s11060-023-04276-9
E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer
Autor:
Shirley Jusino, Camille Chardón-Colón, Armando J Ruiz-Justiz, Margarita Bonilla-Claudio, Angel A. Isidro, Melanie E Cruz-Robles, Harold I. Saavedra, Guillermo N. Armaiz-Pena, Jaleisha Vélez-Velázquez, Yainyrette Rivera-Rivera
Publikováno v:
Exp Biol Med (Maywood)
E2F3 is a transcription factor that may initiate tumorigenesis if overexpressed. Previously, we demonstrated that E2F3 mRNA is overexpressed in breast cancer and that E2F3 overexpression results in centrosome amplification and unregulated mitosis, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29c03254a8ac07b9907c3ab52a17da4
https://doi.org/10.1177/15353702211035693
https://doi.org/10.1177/15353702211035693
Autor:
Patricia C. Rodríguez Rodríguez, Shirley Jusino, Yainyrette Rivera Rivera, Camille Chardón Colón, Janeishly Román González, Harold Saavedra
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f221e6ce54287797387a2168473410
https://doi.org/10.1096/fasebj.2022.36.s1.r5985
https://doi.org/10.1096/fasebj.2022.36.s1.r5985
Autor:
Shirley Jusino, Harold I. Saavedra
Publikováno v:
Experimental Biology and Medicine. 244:1419-1429
The epithelial-to-mesenchymal transition (EMT) is a complex cellular process in which epithelial cells acquire mesenchymal properties. EMT occurs in three biological settings: development, wound healing and fibrosis, and tumor progression. Despite oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed17c5bbef2f0d8a51144a2de4bd233c
https://doi.org/10.1177/1535370219881360
https://doi.org/10.1177/1535370219881360
Publikováno v:
Exp Biol Med (Maywood)
Biological therapies against breast cancer patients with tumors positive for the estrogen and progesterone hormone receptors and Her2 amplification have greatly improved their survival. However, to date, there are no effective biological therapies ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f37b969e992f555bf66f62c3d2986b
https://europepmc.org/articles/PMC8113731/
https://europepmc.org/articles/PMC8113731/
Autor:
Jaleisha Vélez Velázquez, Shirley Jusino, Jaya Padmanabhan, Srikumar Chellappan, Mihaela Marina, Miyoung Lee, Yainyrette Rivera-Rivera, Camille Chardón-Colón, Harold I. Saavedra, Geraldine Vargas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to centrosomes and kinetochores, controlling centrosome separation, chromosome attachments to kinetochores, and the spindle assembly checkpoint. These processes preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d2978e933d961c0c2bd8d4a8ba302c
https://pubmed.ncbi.nlm.nih.gov/33907253
https://pubmed.ncbi.nlm.nih.gov/33907253
Autor:
Harold I. Saavedra, Shirley Jusino
Publikováno v:
Cancer Research. 80:P6-07
Despite being the most aggressive and poorly prognostic breast cancer subtype, there are currently no biological therapies against triple-negative (TN, or ER-PR-Her2-) breast cancers. Our laboratory is finding the sources of novel biological targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5448e5ef9bf8c6e2d023075d53e1c01
https://doi.org/10.1158/1538-7445.sabcs19-p6-07-06
https://doi.org/10.1158/1538-7445.sabcs19-p6-07-06
Publikováno v:
Journal of Clinical Oncology. 38:e13100-e13100
e13100 Background: Triple-negative breast cancer (TNBC) is the most aggressive and poorly prognostic breast cancer subtype, yet there are currently no biological therapies against this subtype. Our laboratory is finding the sources of novel biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fa4a7260f90ab15740320cef767aa0
https://doi.org/10.1200/jco.2020.38.15_suppl.e13100
https://doi.org/10.1200/jco.2020.38.15_suppl.e13100