Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shirley J. Lasch"'
Autor:
Pamela A. Trail, Harold Mastalerz, Raymond A. Firestone, David Willner, Hofstead Sandra J, Shirley J. Lasch, Dalton King, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry. 45:4336-4343
High mole ratio BR96 immunoconjugates were synthesized using branched peptide-doxorubicin linkers designed to liberate doxorubicin following antigen-specific internalization into lysosomes. However, these immunoconjugates are highly prone to noncoval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29fb0884a9989d4a2ec907eb30cf07f
https://doi.org/10.1021/jm020149g
https://doi.org/10.1021/jm020149g
Autor:
Michael A. Walker, Shilpa Radia, Dalton King, Shirley J. Lasch, David Willner, Hofstead Sandra J, Gene M. Dubowchik, Harold Mastalerz, Raymond A. Firestone, Pamela A. Trail
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1529-1532
Bivalent doxorubicin (DOX)-dipeptides ( 16a – c ) were prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates. Conjugate 18b demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933401d420d7b01374ef7d812e2fa84b
https://doi.org/10.1016/s0960-894x(02)00194-4
https://doi.org/10.1016/s0960-894x(02)00194-4
Autor:
Karl Erik Hellström, Yurgaitis D, David Willner, King Hd, Pamela A. Trail, Raymond A. Firestone, Yang Mb, Shirley J. Lasch
Publikováno v:
Bioconjugate Chemistry. 10:279-288
Immunoconjugates of monoclonal antibody BR96 and Doxorubicin have been prepared using a novel series of branched hydrazone linkers. Since each linker bound to the mAb carries two DOX molecules, the DOX/mAb molar ratios of these conjugates were approx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f98627ed9d52e720395d8f7c140b81
https://doi.org/10.1021/bc980100i
https://doi.org/10.1021/bc980100i
Autor:
David Willner, Gary R. Braslawsky, Greenfield Robert S, Shirley J. Lasch, Anna Maria Casazza, Hofstead Sandra J, Ingegerd Hellström, Raymond A. Firestone, Karl Erik Hellström, Pamela A. Trail, Arris J. Henderson, Takushi Kaneko, King Hd
Publikováno v:
Journal of Controlled Release. 39:251-259
BR96-Dox is an immunoconjugate (IC) in which doxorubicin (8 equivalents) is linked via an acid-labile hydrazone to the chimeric MAb BR96. It binds to a modified Le y Ag on tumor cells, which then internalize it via endocytosis into lysosomes. There,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c9bd0cf5063635932136c3bfc6102d4
https://doi.org/10.1016/0168-3659(95)00160-3
https://doi.org/10.1016/0168-3659(95)00160-3
Autor:
David Willner, Greenfield Robert S, Shirley J. Lasch, Hofstead Sandra J, Pamela A. Trail, King Hd, Raymond A. Firestone, Takushi Kaneko, Braslawsky Gary R
Publikováno v:
Bioconjugate Chemistry. 4:521-527
The (6-maleimidocaproyl)hydrazone of doxorubicin was synthesized and conjugated to several mAbs, including chimeric BR96, via a Michael addition reaction to thiol-containing mAbs. DTT reduction of disulfides present in the mAb was a reliable and gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d376fa23fd2adcf44afcec9d99262a04
https://doi.org/10.1021/bc00024a015
https://doi.org/10.1021/bc00024a015
Autor:
David Willner, Hofstead Sandra J, Kathleen W. Mosure, Linda Padilla, Gene M. Dubowchik, Pamela A. Trail, Shirley J. Lasch, Raymond A. Firestone, Jay O. Knipe
Publikováno v:
Bioconjugate chemistry. 13(4)
The anticancer drug doxorubicin (DOX) has been linked to chimeric BR96, an internalizing monoclonal antibody that binds to a Lewis(y)-related, tumor-associated antigen, through two lysosomally cleavable dipeptides, Phe-Lys and Val-Cit, giving immunoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a77046ac1d541d0a19f366b28b419a3
https://pubmed.ncbi.nlm.nih.gov/12121142
https://pubmed.ncbi.nlm.nih.gov/12121142
Autor:
Anna Maria Casazza, David Willner, Ingegerd Hellström, Hofstead Sandra J, Shirley J. Lasch, Arris J. Henderson, Raymond A. Firestone, Pamela A. Trail, Hellstrom Karl Erik
Publikováno v:
Science (New York, N.Y.). 261(5118)
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The monoclonal antibody binds an antigen related to Lewis Y that is abundantly expressed at the surface of cells from many human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ad6d4b6d5f17d7e4031a8bcb09abd3
https://pubmed.ncbi.nlm.nih.gov/8327892
https://pubmed.ncbi.nlm.nih.gov/8327892