Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shirley H.Y. Hung"'
Publikováno v:
Annals of the New York Academy of Sciences. 696:9-19
FK-506 and cyclosporin A (CsA) are potent immunosuppressive agents used clinically to prevent tissue rejection. Interest in the development of more effective immunosuppressive drugs has led to an intense effort toward understanding their biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932e14978c2a35058fc2c045a800927b
https://doi.org/10.1111/j.1749-6632.1993.tb17137.x
https://doi.org/10.1111/j.1749-6632.1993.tb17137.x
Autor:
John D. Leszyk, Elsa Lam, Patrick R. Griffin, T J Sewell, Mary M. Martin, Jimmy R. Calaycay, Hollis R. Williams, Jeffrey R. Weidner, John G. Cryan, Shirley H.Y. Hung
Publikováno v:
Journal of Biological Chemistry. 269:21094-21102
FK-506, a potent immunosuppressive drug, acts during the commitment phase of T-lymphocyte activation to block a subset of calcium-associated events necessary for transcription of certain early lymphokine genes. The drug binds to an abundant, cytosoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26e5884786433c60662a8404a137d8cb
https://doi.org/10.1016/s0021-9258(17)31934-8
https://doi.org/10.1016/s0021-9258(17)31934-8
Autor:
Mary Jo Staruch, Mark T. Goulet, Shirley Lin, Matthew J. Wyvratt, Francis J. Dumont, Derek W. Hodkey, John Siekierka, Shirley H.Y. Hung
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:927-930
Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff40b24afa11bc5e26e17163d2adf88
https://doi.org/10.1016/s0960-894x(01)80265-1
https://doi.org/10.1016/s0960-894x(01)80265-1
Autor:
John Siekierka, Shirley H.Y. Hung, John G. Cryan, P. J. Hodges, Nolan H. Sigal, Heidi Greulich, Gregory J. Wiederrecht, D. Boulton
Publikováno v:
Journal of Biological Chemistry. 265:21011-21015
We have recently isolated an abundant cytosolic protein from human T-cells which specifically binds the immunosuppressive agent, FK-506. The FK-506-binding protein (FKBP) is a member of a novel class of proteins possessing peptidyl-prolyl cis-trans i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31be2d01e9b2c41da633551365468f26
https://doi.org/10.1016/s0021-9258(17)45319-1
https://doi.org/10.1016/s0021-9258(17)45319-1
Publikováno v:
Biochemical and biophysical research communications. 180(2)
Summary Recently, the amino acid sequence of a 12 Kd endogenous protein inhibitor of protein kinase C (PKC-I 2) has been shown to be identical to that of the 12 KDa receptor for the immunosuppressive drug, FK-506. In view of this observation we exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ddc3e9bc4350ba85b3bbf0eaf1d802
https://pubmed.ncbi.nlm.nih.gov/1719972
https://pubmed.ncbi.nlm.nih.gov/1719972
Publikováno v:
Nature. 341(6244)
CYCLOSPORIN A and the newly discovered immunosuppressant, FK-506, are potent inhibitors of T cell activation. In addition to their clinical importance in the prevention of allograft rejection, cyclosporin A and FK-506 represent important reagents for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33287045341c7996cce9ed13b14afab
https://pubmed.ncbi.nlm.nih.gov/2477714
https://pubmed.ncbi.nlm.nih.gov/2477714