Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Shirley G K Seah"'
Autor:
Conrad E Z Chan, Shirley G K Seah, De Hoe Chye, Shane Massey, Maricela Torres, Angeline P C Lim, Steven K K Wong, Jacklyn J Y Neo, Pui San Wong, Jie Hui Lim, Gary S L Loh, Dongling Wang, Jerome D Boyd-Kirkup, Siyu Guan, Dipti Thakkar, Guo Hui Teo, Kiren Purushotorman, Paul E Hutchinson, Barnaby E Young, Jenny G Low, Paul A MacAry, Hannes Hentze, Venkateshan S Prativadibhayankara, Kantharaj Ethirajulu, Jason E Comer, Chien-Te K Tseng, Alan D T Barrett, Piers J Ingram, Trevor Brasel, Brendon John Hanson
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253487 (2021)
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing windows. We report the generation and development of SC31, a potent SARS-CoV-2 neutralizin
Externí odkaz:
https://doaj.org/article/98d0e9238a8f44f8a516de81e7cb9d0e
Autor:
Agata Blasiak, Anh T. L. Truong, Peter Wang, Lissa Hooi, De Hoe Chye, Shi-Bei Tan, Kui You, Alexandria Remus, David Michael Allen, Louis Yi Ann Chai, Conrad E.Z. Chan, David C. B. Lye, Gek-Yen G. Tan, Shirley G. K. Seah, Edward Kai-Hua Chow, Dean Ho
Publikováno v:
ACS Nano. 16:15141-15154
Nanomedicine-based and unmodified drug interventions to address COVID-19 have evolved over the course of the pandemic as more information is gleaned and virus variants continue to emerge. For example, some early therapies (e.g., antibodies) have expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd506e481c6e9e0142c387b69d89602
https://doi.org/10.1021/acsnano.2c06366
https://doi.org/10.1021/acsnano.2c06366
Autor:
Stephen J. Turner, Matthew R. Olson, Sammy Bedoui, Kathryn M. Edenborough, Marie Greyer, Andrew M. Lew, Peter C. Doherty, Jolie G. Cullen, Shirley G K Seah
Publikováno v:
The Journal of Immunology. 193:5420-5433
Although CD4+ T cell help (Th) is critical for inducing optimal B cell and CD8+ T cell responses, it remains unclear whether induction of CD4+ Th responses postinfection are also dependent on CD4+ T cell help. In this study, we show that activation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3966dab3cc871f523f324cf1f55dfda5
https://doi.org/10.4049/jimmunol.1303359
https://doi.org/10.4049/jimmunol.1303359
Autor:
Manuela S Hancock, Emma M. Carrington, Stephen J. Turner, Gabrielle T. Belz, Wy Ching Ng, Nicole L. La Gruta, Yifan Zhan, Jamie L. Brady, Robyn M. Sutherland, Andrew M. Lew, Lorena E. Brown, Shirley G K Seah
Publikováno v:
European Journal of Immunology. 42:1744-1754
The importance of costimulation on CD4+ T cells has been well documented. However, primary CTLs against many infections including influenza can be generated in the absence of CD4+ T-cell help. The role of costimulation under such “helpless” circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24d6a45d9e342a9b84623bb1cb783f84
https://doi.org/10.1002/eji.201142211
https://doi.org/10.1002/eji.201142211
Autor:
Shirley G K Seah, Jose A Villadangos, Yifan Zhan, Annemarie van Nieuwenhuijze, Sammy Bedoui, Andrew M. Lew, Ian P. Wicks, Justine D. Mintern, Nancy Wang, Emma M. Carrington, Yuekang Xu
Publikováno v:
European Journal of Immunology. 41:2585-2595
Resident CD8(+) DCs perform several functions, including cross-presenting antigen and rapidly engulfing the Gram-positive intracellular pathogen Listeria monocytogenes. Little is known about how these functions of CD8(+) DCs are modulated. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04c7db1fa5667ecacb4708c52aaf7e3
https://doi.org/10.1002/eji.201141540
https://doi.org/10.1002/eji.201141540
Autor:
Kathryn M. Edenborough, Stephen J. Turner, Andrew M. Lew, Matthew R. Olson, Shirley G K Seah, Peter C. Doherty
Publikováno v:
Immunology and cell biology. 92(7)
CD40-CD154 (CD40 ligand) interactions are essential for the efficient priming of CD8(+) cytotoxic T lymphocyte (CTL) responses. This is typically via CD4(+)CD154(+) T-cell-dependent 'licensing' of CD40(+) dendritic cells (DCs); however, DCs infected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e178be55f8323fa2fbfe4447643ad71f
https://pubmed.ncbi.nlm.nih.gov/24777309
https://pubmed.ncbi.nlm.nih.gov/24777309
Autor:
Shirley G K Seah, Yifan Zhan, Nicole L. La Gruta, Andrew M. Lew, Wy Ching Ng, Lorena E. Brown, Robyn M. Sutherland, Manuela S Hancock, Emma M. Carrington, Jamie L. Brady, Stephen J. Turner
Publikováno v:
Journal of leukocyte biology. 93(1)
Direct costimulation of CD8+ T cells is more important than the canonical licensing of DCs by CD4 help, in influenza. The helper-dependent pathway of priming CD8+ T cells involves “licensing” of DCs by CD40L on CD4+ T cells. The helper-independen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd1aca7847dbd8153412d9dadf77863
https://pubmed.ncbi.nlm.nih.gov/23108101
https://pubmed.ncbi.nlm.nih.gov/23108101
Autor:
Shirley G K, Seah, Emma M, Carrington, Wy C, Ng, Gabrielle T, Belz, Jamie L, Brady, Robyn M, Sutherland, Manuela S, Hancock, Nicole L, La Gruta, Lorena E, Brown, Stephen J, Turner, Yifan, Zhan, Andrew M, Lew
Publikováno v:
European journal of immunology. 42(7)
The importance of costimulation on CD4(+) T cells has been well documented. However, primary CTLs against many infections including influenza can be generated in the absence of CD4(+) T-cell help. The role of costimulation under such "helpless" circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::737f14fe4e53651c3d0ecd5fe95c3ddb
https://pubmed.ncbi.nlm.nih.gov/22585421
https://pubmed.ncbi.nlm.nih.gov/22585421
Autor:
Gabrielle T. Belz, Stephen J. Turner, Yifan Zhan, Robyn M. Sutherland, Andrew M. Lew, Shirley G K Seah, Lorena E. Brown, Nicole L. La Gruta, Emma M. Carrington, Jamie L. Brady
Publikováno v:
European journal of immunology. 41(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10eb35466f62ed5ff34a614f19685274
https://pubmed.ncbi.nlm.nih.gov/21469136
https://pubmed.ncbi.nlm.nih.gov/21469136
Autor:
Yifan Zhan, Christina Cheers, Andrew M. Lew, Emma M. Carrington, Jamie L. Brady, Yuekang Xu, Shirley G K Seah, Jose A Villadangos, Li Wu, Ben A. Croker
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 185(4)
IL-12 is such a pivotal cytokine that it has been called the third signal for T cell activation, TCR engagement being the first and costimulation being the second. It has been generally viewed that the resident CD8+ dendritic cell (DC) subset is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeded78076d0ab7f0599b22ee2fe31d4
https://pubmed.ncbi.nlm.nih.gov/20644172
https://pubmed.ncbi.nlm.nih.gov/20644172