Výsledky vyhledávání - "Shirley B. Shelton"

A simple, efficient tool for assessment of mice after unilateral cortex injury

Autor: Patrick Sullivan, David B. Pettigrew, Keith A. Crutcher, Kenneth I. Strauss, Shirley B. Shelton, Weidong Zhou, Alison Hermann

Publikováno v: Journal of Neuroscience Methods. 168:431-442

A refined battery of neurological tests, SNAP (Simple Neuroassessment of Asymmetric Impairment), was developed and validated to efficiently assess neurological deficits induced in a mouse model of traumatic brain injury. Four to 7-month old mice were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3865a63e6072f9d7a5a5347576c51dc
https://doi.org/10.1016/j.jneumeth.2007.11.003

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Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells

Autor: Shirley B. Shelton, Gail V.W. Johnson, Pavan K. Krishnamurthy

Publikováno v: Journal of Neuroscience Research. 76:110-120

Cyclin-dependent kinase-5 (CDK5), a unique CDK family member, is active primarily in the central nervous system (CNS). Previous studies suggest that CDK5 is proapoptotic and contributes to tau hyperphosphorylation and neurodegeneration in Alzheimer's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d72d6698f28e3ae21530dcadc2100b3
https://doi.org/10.1002/jnr.20051

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Cyclin-dependent kinase-5 in neurodegeneration

Autor: Shirley B. Shelton, Gail V.W. Johnson

Publikováno v: Journal of Neurochemistry. 88:1313-1326

Cyclin-dependent kinase-5 (CDK5) is predominantly active in the nervous system and it is well established that CDK5 is essential in neuronal development. In addition to its recognized role in development, there is increasing evidence that CDK5 may be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bddc259b0cbff06f108308cda33b95f7
https://doi.org/10.1111/j.1471-4159.2003.02328.x

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Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells

Autor: Gail V.W. Johnson, Shirley B. Shelton

Publikováno v: Journal of neuroscience research. 66(2)

In the Alzheimer disease brain, the microtubule-associated protein tau is hyperphosphorylated. There is also evidence that apoptotic-like processes may contribute to the neuronal loss in AD. In an apoptotic model that involves replating neuronal PC12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712edf562b1d6fb05bf6d4711a83eef9
https://pubmed.ncbi.nlm.nih.gov/11592115

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Magnetic resonance imaging in the diagnosis of degenerative lumbosacral stenosis in four dogs

Autor: Shirley B. Shelton, Jacek J. de Haan, Norman Ackerman

Publikováno v: Veterinary surgery : VS. 22(1)

Magnetic resonance imaging was used to diagnose degenerative lumbosacral stenosis in four dogs that had physical and neurologic signs consistent with a cauda equina lesion. Nerve root displacement by protruding disc material and loss of epidural fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7815e798233cbf8729c51b11a02f2f2
https://pubmed.ncbi.nlm.nih.gov/8488668

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