Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shirley A. Aguirre"'
Publikováno v:
Journal of Excipients and Food Chemicals, Vol 4, Iss 3 (2016)
Cremaphor® ELP (CrELP) has been used to emulsify and solubilize water-insoluble substances in the pharmaceutical industry for oral, topical and parenteral preparations, but its safety profile via the intravenous route is yet to be established. In th
Externí odkaz:
https://doaj.org/article/8a3037e8b1fd4efea6e07583baefc3ed
Publikováno v:
Ciencia Latina Revista Científica Multidisciplinar. 6:9451-9474
En el Ecuador, la implementación de la educación inclusiva en las universidades se ha implementado desde la Constitución del año 2008, y la UPSE ha sabido implementarla de forma efectiva. El objetivo de la presente investigación fue de determina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f69c842da61c9c70e16bbe77b5ca050
https://doi.org/10.37811/cl_rcm.v6i6.4081
https://doi.org/10.37811/cl_rcm.v6i6.4081
Publikováno v:
Pharmaceutical Research. 35
Evaluate 21 formulation vehicles administered to rabbits after intravitreal injection for tolerability and safety. Forty-two Dutch Belted rabbits were anesthetized, and the eyes received a single intravitreal injection of the excipient formulation. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2feccd2e59f536e9ee42dd63cbdfb8fa
https://doi.org/10.1007/s11095-018-2450-1
https://doi.org/10.1007/s11095-018-2450-1
Autor:
Chang-Ning Liu, Qinghai Peng, David W Yates, Wenhu Huang, Heather Devantier, Shirley A Aguirre
Publikováno v:
Toxicology Research and Application, Vol 1 (2017)
Although sodium iodate (NaIO 3 )-induced retinal injury model has been widely used in rodents, its application in large animal species has encountered variation in retinal toxicity. NaIO 3 induced retinal degeneration and functional changes in sheep,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::83f04f7ac6521ca6e44c215912edee78
https://doaj.org/article/4b431866f3c143f9b1010f8654357a65
https://doaj.org/article/4b431866f3c143f9b1010f8654357a65
Autor:
Jeffrey R. May, Kimbie Palacio, Jianying Wang, Brad Hirakawa, Ling Liu, Yizhong Zhang, Gregory J. Stevens, Shirley A. Aguirre, Winston Evering
Publikováno v:
Toxicologic Pathology. 42:1117-1129
This investigation examined microRNA-208a (miR-208a) as a potential biomarker of isoproterenol (ISO)-induced cardiac injury in superoxide dismutase-2 ( Sod2+/−) and the wild-type mice, and the potential sensitivity of Sod2+/− mice to ISO-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371cadec88bf3f8aa9ccde21dd8295d8
https://doi.org/10.1177/0192623314525684
https://doi.org/10.1177/0192623314525684
Autor:
Wesley Scott, Robert H. Denlinger, Sophia Randolph, Natilie Hosea, Ling Liu, Bora Han, Jeffrey R. May, Shirley A. Aguirre, Leigh Ann Burns-Naas
Publikováno v:
Toxicologic Pathology. 42:422-434
Dexamethasone was given in 2 oral dosing regimens with repeat dose oral administration of the gamma secretase inhibitor (GSI), PF-03084014, in Sprague-Dawley (SD) rats in order to evaluate the effects of coadministration of dexamethasone on GSI-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3917ab2c234117384681a2b202dbba9d
https://doi.org/10.1177/0192623313486315
https://doi.org/10.1177/0192623313486315
Autor:
Anand Giddabasappa, Qinghai Peng, Wenhu Huang, Walter Collette, Michelle Twamley, Dalia Kalabat, John David, Shirley A. Aguirre
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 152(2)
Retinal toxicity is one of the leading causes of attrition in drug development, and drug-induced retinal toxicity remains an issue in both drug discovery and postmarketed drugs. Derisking strategies to help with early identification of retinal injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882e4efe1b948f25e9122f084d477249
https://pubmed.ncbi.nlm.nih.gov/27208084
https://pubmed.ncbi.nlm.nih.gov/27208084
Autor:
Gilles H. Goetz, Michele McTigue, Max Parker, Ya-Li Deng, Nambu Mitchell David, J. Jean Cui, Shinji Yamazaki, Jia Lei, Neil Grodsky, Shirley A. Aguirre, Jacqui Elizabeth Hoffman, Kevin Ryan, Hong Shen, Phuong Le, Sergei Timofeevski, James G. Christensen, Helen Y. Zou, Cheng Hengmiao, Brion W. Murray, Michelle Tran-Dubé, Mehran Jalaie, Qiuhua Li, Pairish Mason Alan
Publikováno v:
Journal of Medicinal Chemistry. 55:8091-8109
The c-MET receptor tyrosine kinase is an attractive oncology target because of its critical role in human oncogenesis and tumor progression. An oxindole hydrazide hit 6 was identified during a c-ME...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a253c3b903e7bc7ae29a14c9a9b40dd
https://doi.org/10.1021/jm300967g
https://doi.org/10.1021/jm300967g
Publikováno v:
Journal of Applied Toxicology. 32:1008-1020
PF-04254644 is a selective kinase inhibitor of mesenchymal epithelial transition factor/hepatocyte growth factor receptor with known off-target inhibitory activity against the phosphodiesterase (PDE) family. Rats given repeated oral doses of PF-04254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a37a5f1c15b2588f886a05c56551980
https://doi.org/10.1002/jat.2801
https://doi.org/10.1002/jat.2801
Publikováno v:
Toxicologic Pathology. 40:797-806
Maleic acid was formulated in 0.7% saline and injected intravitreally in rabbits in order to evaluate ocular safety and tolerability. Maleic acid was formulated within a narrow pH range (2–3), administered in a fixed volume (100 µl), and concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92c5881a071c1b7764a04ddb9cbd6c7
https://doi.org/10.1177/0192623312441400
https://doi.org/10.1177/0192623312441400