Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Shirley, Uitte de Willige"'
1
Akademický článek
Generation and characterization of monoclonal antibodies against the N-terminus of alpha-2-antiplasmin.
Autor: Shiraazkhan Abdul, Miet Peeters, Els Brouwers, Joyce J M C Malfliet, Frank W G Leebeek, Paul J Declerck, Dingeman C Rijken, Shirley Uitte de Willige
Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196911 (2018)
Around 70% of circulating alpha-2-antiplasmin (α2AP), the main natural plasmin inhibitor, is N-terminally cleaved between residues Pro12 and Asn13 by antiplasmin-cleaving enzyme. This converts native Met-α2AP into the more potent fibrinolysis inhib
Externí odkaz: https://doaj.org/article/e2a6b9d1253348ceb014e9f164bf1048
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2
Akademický článek
Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease.
Autor: Shirley Uitte de Willige, Fiona M Keane, David G Bowen, Joyce J M C Malfliet, H Emma Zhang, Bharvi Maneck, Geoffrey W McCaughan, Frank W G Leebeek, Dingeman C Rijken, Mark D Gorrell
Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178987 (2017)
BACKGROUND AND AIM:Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and endopeptidase activities. We aimed to assess the correlation between cFAP
Externí odkaz: https://doaj.org/article/f1745d1ee4c94a02bdd005d616eb8aec
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4
Inhibition of Fibrinolysis by Coagulation Factor XIII
Autor: Dingeman C. Rijken, Shirley Uitte de Willige
Publikováno v: BioMed Research International, Vol 2017 (2017)
BioMed Research International
BioMed Research International. Hindawi Publishing Corporation
The inhibitory effect of coagulation factor XIII (FXIII) on fibrinolysis has been studied for at least 50 years. Our insight into the underlying mechanisms has improved considerably, aided in particular by the discovery that activated FXIII cross-lin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2406412b3ea921100da8c9188c5cd445
https://doi.org/10.1155/2017/1209676
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5
On the localization of the cleavage site in human alpha-2-antiplasmin, involved in the generation of the non-plasminogen binding form
Autor: Robert A. S. Ariëns, Shiraazkhan Abdul, Shirley Uitte de Willige, Frank W.G. Leebeek, Dingeman C. Rijken, Dick H. W. Dekkers
Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 18(5), 1162-1170. Wiley-Blackwell Publishing Ltd
Background: Alpha‐2‐antiplasmin (α2AP) is the main natural inhibitor of plasmin. The C‐terminus of α2AP is crucial for the initial interaction with plasmin(ogen) and the rapid inhibitory mechanism. Approximately 35% of circulating α2AP has l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57087d5b2ed9ed25dd375cdc03224cd
https://pubmed.ncbi.nlm.nih.gov/32034861
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6
Natural heterogeneity of alpha 2-antiplasmin: functional and clinical consequences
Autor: Dingeman C. Rijken, Shiraazkhan Abdul, Frank W.G. Leebeek, Shirley Uitte de Willige
Publikováno v: Blood, 127(5), 538-545. American Society of Hematology
Human alpha 2-antiplasmin (alpha 2AP, also called alpha 2-plasmin inhibitor) is the main physiological inhibitor of the fibrinolytic enzyme plasmin. alpha 2AP inhibits plasmin on the fibrin clot or in the circulation by forming plasmin-antiplasmin co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81606e924209a95eb29dc14571cd8cb1
https://doi.org/10.1182/blood-2015-09-670117
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7
Plasma levels of soluble fibroblast activation protein in arterial thrombosis; determinants and cleavage of its substrate alpha-2-antiplasmin
Autor: Jaap W. Deckers, Dingeman C. Rijken, Frank W.G. Leebeek, Shirley Uitte de Willige, Diederik W.J. Dippel, Joyce J. M. C. Malfliet
Publikováno v: International Journal of Cardiology, 178, 105-110. Elsevier Ireland Ltd
Background: Fibroblast activation protein (FAP) is a transmembrane glycoprotein with dipeptidyl-peptidase and endopeptidase activities and circulates in blood in a truncated, soluble form (sFAP). Fibrinolysis inhibitor alpha 2-antiplasmin (alpha 2AP)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7424695ecf87426931e9c0409e3956a2
https://pure.eur.nl/en/publications/43851449-f30c-4f25-bdee-bbc74656a02b
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8
The level of circulating fibroblast activation protein correlates with incorporation of alpha-2-antiplasmin into the fibrin clot
Autor: Joyce J.C.M. Malfliet, Shirley Uitte de Willige, Dingeman C. Rijken, Shiraazkhan Abdul, Frank W.G. Leebeek
Publikováno v: Thrombosis Research, 166, 19-21. Elsevier Ltd.
Introduction Circulating fibroblast activation protein (cFAP) cleaves alpha-2-antiplasmin (α2AP) N-terminally, converting native Met-α2AP into Asn-α2AP. Previous studies in purified model systems showed that Asn-α2AP is faster incorporated into a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d507d360e34421e8118438a1d35d6e
https://pubmed.ncbi.nlm.nih.gov/29649768
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9
Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease
Autor: David G. Bowen, Fiona M. Keane, Geoffrey W. McCaughan, Mark D. Gorrell, Bharvi Maneck, H. Emma Zhang, Dingeman C. Rijken, Shirley Uitte de Willige, Frank W.G. Leebeek, Joyce J. M. C. Malfliet
Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178987 (2017)
PLoS ONE
PLoS One (print), 12(6):e0178987. Public Library of Science
Background and aim Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and endopeptidase activities. We aimed to assess the correlation between cFAP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5583e98fed0be57acf8c64649687b030
http://europepmc.org/articles/PMC5459491?pdf=render
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10
Fibrinogen γ′ increases the sensitivity to activated protein C in normal and factor V Leiden plasma
Autor: Elisabetta Castoldi, Paolo Simioni, Rogier M. Bertina, Jan Rosing, Shirley Uitte de Willige, Farida Omarova, Robert A. S. Ariëns
Publikováno v: Blood, 124(9), 1531-1538. The American Society of Hematology
Activated protein C (APC) resistance, often associated with the factor V (FV) Leiden mutation, is the most common risk factor for venous thrombosis. We observed increased APC resistance in carriers of fibrinogen gamma gene (FGG) haplotype 2, which is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd46d52d02a49add69aab84b5ace465
https://doi.org/10.1182/blood-2014-02-554055
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