Zobrazeno 1 - 10
of 607
pro vyhledávání: '"Shirley, Liu"'
Autor:
Phillip B. Nicol, Danielle Paulson, Gege Qian, X. Shirley Liu, Rafael Irizarry, Avinash D. Sahu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Single-cell transcriptomics has emerged as a powerful tool for understanding how different cells contribute to disease progression by identifying cell types that change across diseases or conditions. However, detecting changing cell types is
Externí odkaz:
https://doaj.org/article/4f488a03a7a34c2f888328d58652862e
Autor:
Yi Zhang, Guanjue Xiang, Alva Yijia Jiang, Allen Lynch, Zexian Zeng, Chenfei Wang, Wubing Zhang, Jingyu Fan, Jiajinlong Kang, Shengqing Stan Gu, Changxin Wan, Boning Zhang, X. Shirley Liu, Myles Brown, Clifford A. Meyer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Recent advances in single-cell RNA sequencing have shown heterogeneous cell types and gene expression states in the non-cancerous cells in tumors. The integration of multiple scRNA-seq datasets across tumors can indicate common cell types an
Externí odkaz:
https://doaj.org/article/77ffd7f0015d4d809b9d15d53098ceaf
Autor:
Bin Xie, Yulong Li, Karim A Benhadji, X Shirley Liu, Xiangyang Wu, Hailing Liu, Xi Xiao, Huizhu Liu, Qingyang Ding, Caibin Sheng, Rongbin Zheng, Quan Yu, Xihao Hu, Tengfei Xiao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/7c9ee5c6b095457dbff310cea9044fb5
Autor:
Florian Perner, Homa Rahnamoun, Daniela V. Wenge, Yijun Xiong, Athina Apazidis, Disha Anand, Charlie Hatton, Yanhe Wen, Shengqing Gu, X Shirley Liu, Wenbin Xiao, Sheng F. Cai, Ross L. Levine, Gerard M. Mcgeehan, Scott A. Armstrong
Publikováno v:
HemaSphere, Vol 7, p e6233123 (2023)
Externí odkaz:
https://doaj.org/article/576f5a4c6dfd45daabbe17b293ba2228
Autor:
Ryan J. Williams, Olivia C. Sehl, Julia J. Gevaert, Shirley Liu, John J. Kelly, Paula J. Foster, John A. Ronald
Publikováno v:
Tomography, Vol 9, Iss 1, Pp 178-194 (2023)
Magnetic particle imaging (MPI) provides hotspot tracking and direct quantification of superparamagnetic iron oxide nanoparticle (SPIO)-labelled cells. Bioluminescence imaging (BLI) with the luciferase reporter gene Akaluc can provide complementary i
Externí odkaz:
https://doaj.org/article/0cfef28ed4874c5a9bf9f0ed85783eab
Autor:
Wubing Zhang, Shourya S. Roy Burman, Jiaye Chen, Katherine A. Donovan, Yang Cao, Chelsea Shu, Boning Zhang, Zexian Zeng, Shengqing Gu, Yi Zhang, Dian Li, Eric S. Fischer, Collin Tokheim, X. Shirley Liu
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 5, Pp 882-898 (2022)
Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery. However, the susceptibility of proteins for targeting
Externí odkaz:
https://doaj.org/article/e1cece95525d43e4af03b52377a9d03e
Autor:
Xintao Qiu, Nadia Boufaied, Tarek Hallal, Avery Feit, Anna de Polo, Adrienne M. Luoma, Walaa Alahmadi, Janie Larocque, Giorgia Zadra, Yingtian Xie, Shengqing Gu, Qin Tang, Yi Zhang, Sudeepa Syamala, Ji-Heui Seo, Connor Bell, Edward O’Connor, Yang Liu, Edward M. Schaeffer, R. Jeffrey Karnes, Sheila Weinmann, Elai Davicioni, Colm Morrissey, Paloma Cejas, Leigh Ellis, Massimo Loda, Kai W. Wucherpfennig, Mark M. Pomerantz, Daniel E. Spratt, Eva Corey, Matthew L. Freedman, X. Shirley Liu, Myles Brown, Henry W. Long, David P. Labbé
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The role of MYC in transcriptional reprogramming in prostate cancer remains poorly characterized. Here, MYC overexpression antagonizes the canonical AR transcriptional program leading to prostate tumor initiation and progression by disrupting transcr
Externí odkaz:
https://doaj.org/article/bc90d144fd374a6387fda7079a332f9f
Autor:
Kathleen M C Sullivan, Marta Vilalta, Linda S Ertl, Yu Wang, Carolyn Dunlap, Karen Ebsworth, Bin N Zhao, Shijie Li, Yibin Zeng, Zhenhua Miao, Pingchen Fan, Venkat Mali, Christopher Lange, Darren McMurtrie, Ju Yang, Rebecca Lui, Ryan Scamp, Vicky Chhina, Alice Kumamoto, Simon Yau, Ton Dang, Ashton Easterday, Shirley Liu, Shichang Miao, Israel Charo, Thomas J Schall, Penglie Zhang
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286724 (2023)
The interaction of PD-L1 with PD-1 is a major immune checkpoint that limits effector T cell function against cancer cells; monoclonal antibodies that block this pathway have been approved in multiple tumor indications. As a next generation therapy, s
Externí odkaz:
https://doaj.org/article/a53419583b96441186b367f58673ff4f
Autor:
Haowen Zhang, Li Song, Xiaotao Wang, Haoyu Cheng, Chenfei Wang, Clifford A. Meyer, Tao Liu, Ming Tang, Srinivas Aluru, Feng Yue, X. Shirley Liu, Heng Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
As studies continue sequencing with deeper coverage, computational processing of these profiles has become increasingly resource consuming. Here the authors designed an efficient computational method called Chromap to align and preprocess high throug
Externí odkaz:
https://doaj.org/article/0d8e074a07ed48daaa24e1ce45413134
Autor:
Jing Liu, Collin Tokheim, Jonathan D. Lee, Wenjian Gan, Brian J. North, X. Shirley Liu, Pier Paolo Pandolfi, Wenyi Wei
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The impact of genetic fusions on degrons, which are motifs for ubiquitin-mediated protein degradation, has not been fully explored. Here, the authors analyse fusion genes affecting degrons in pan-cancer genomics data, validate their functional impact
Externí odkaz:
https://doaj.org/article/94598e27d4dd4b42ab93f5a55245e282