Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shirish Yakkundi"'
Autor:
Jane A. English, Débora F. Leite, Shirish Yakkundi, Philip N. Baker, Louise C. Kenny, Aude-Claire Morillon, Lee A. Gethings, Grégoire Thomas, Fergus P. McCarthy
Publikováno v:
Metabolomics
Introduction Small for gestational age (SGA) may be associated with neonatal morbidity and mortality. Our understanding of the molecular pathways implicated is poor. Objectives Our aim was to determine the metabolic pathways involved in the pathophys
Autor:
Philip N. Baker, Louise C. Kenny, Grégoire Thomas, James I. Langridge, Aude-Claire Morillon, Fergus P. McCarthy, Lee A. Gethings, Jane A. English, Shirish Yakkundi
Publikováno v:
Metabolomics
METABOLOMICS
METABOLOMICS
Introduction Preterm birth (PTB) is defined as birth occurring before 37 weeks’ gestation, affects 5–9% of all pregnancies in developed countries, and is the leading cause of perinatal mortality. Spontaneous preterm birth (sPTB) accounts for 31
Autor:
Hussain Mulla, James McElnay, Paul S. Monks, Anthony J Nunn, Marie Hubbard, Hitesh Pandya, Shirish Yakkundi, Rebecca Cordell, Mark A. Turner
Publikováno v:
European Journal of Pediatrics
Neonates administered ethanol-containing medicines are potentially at risk of dose-dependent injury through exposure to ethanol and its metabolite, acetaldehyde. Here, we determine blood ethanol and acetaldehyde concentrations in 49 preterm infants (
Autor:
Anthony J Nunn, Tuuli Metsvaht, Georgi Nellis, Irja Lutsar, Hitesh Pandya, Mark A. Turner, Heili Varendi, Hussain Mulla, Jennifer C Duncan, James McElnay, Shirish Yakkundi
Publikováno v:
Pharmaceutical Research. 32:1084-1093
Systemic exposure to parabens in the neonatal population, in particular propyl-parabens (PPB), remains a concern. Blood concentrations and kinetics of methyl-parabens (MPB) and PPB were therefore determined in neonates receiving medicines containing
Autor:
Heili Varendi, Pascal Vaconsin, Hitesh Pandya, G Nellis, Anthony J Nunn, Jennifer C Duncan, André Rieutord, James McElnay, Shirish Yakkundi, Tuuli Metsvaht, Irja Lutsar, Utpal Shah, Thomas Storme, Hussain Mulla, Mark A. Turner
Publikováno v:
Advanced Drug Delivery Reviews. 73:89-101
Newborn babies can require significant amounts of medication containing excipients intended to improve the drug formulation. Most medicines given to neonates have been developed for adults or older children and contain excipients thought to be safe i
Autor:
Gillian Thurley, Jeffrey S. Millership, James McElnay, Ahmed F. Hawwa, Henry L. Halliday, Shirish Yakkundi, Anthony J Nunn, Paul S. Collier, Michael D. Shields, Paul M. Westwood
Publikováno v:
British Journal of Clinical Pharmacology. 75:1265-1276
Aims - To characterize the population pharmacokinetics of ranitidine in critically ill children and to determine the influence of various clinical and demographic factors on its disposition. Methods - Data were collected prospectively from 78 paediat
Publikováno v:
Yakkundi, S, Mulla, H, Pandya, H, Turner, M A & McElnay, J 2016, ' Quantitative analysis of methyl and propyl parabens in neonatal DBS using LC–MS/MS ', Bioanalysis, vol. 8, no. 11, pp. 1173-1182 . https://doi.org/10.4155/bio-2016-0029
BIOANALYSIS
BIOANALYSIS
Aim: Excipients are used to overcome the chemical, physical and microbiological challenges posed by developing formulated medicines. Both methyl and propyl paraben are commonly used in pediatric liquid formulations. There is no data on systemic expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6caca91aa5eb7362ba3380d8782b70a
https://pure.qub.ac.uk/en/publications/quantitative-analysis-of-methyl-and-propyl-parabens-in-neonatal-dbs-using-lcmsms(bf554722-c65a-40b7-a749-3f35cf2c203b).html
https://pure.qub.ac.uk/en/publications/quantitative-analysis-of-methyl-and-propyl-parabens-in-neonatal-dbs-using-lcmsms(bf554722-c65a-40b7-a749-3f35cf2c203b).html
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 56:1057-1063
A novel approach has been developed to determine ranitidine in paediatric samples using dried blood spots (DBS) on Guthrie cards (Whatman 903). A selective and sensitive HPLC-MS/MS assay has been developed and validated using small volumes of blood (
Publikováno v:
Analytica Chimica Acta. 473:177-182
An experiment was designed to establish the relationship between halofuginone (HFG) contaminated feed and HFG residues in eggs. Five groups of six-layer hens each were fed with HFG contaminated diets at concentrations ranging between 1 and 10% of the
Publikováno v:
The Analyst. 126:1985-1989
A method is described for the quantitative confirmation of 4,4′-dinitrocarbanilide (DNC), the marker residue for nicarbazin in chicken liver and eggs. The method is based on LC coupled to negative ion electrospray MS-MS of tissue extracts prepared