B7h (ICOS-L) Maintains Tolerance at the Fetomaternal Interface

Autor: Arlene H. Sharpe, Nora Kochupurakkal, Andrea Vergani, Leonardo V. Riella, Lola Chabtini, Hideo Yagita, Francesca D'Addio, Lei Huang, Bechara Mfarrej, Brian Smith, Pranal J. Dakle, Paolo Fiorina, Shirine Dada, Indira Guleria, La Tonya Adams, Andrew L. Mellor

Publikováno v: The American Journal of Pathology. 182:2204-2213

In a successful pregnancy, the semiallogeneic fetus is not rejected by the maternal immune system, which implies tolerance mechanisms protecting fetal tissues from maternal immune attack. Here we report that the ICOS-B7h costimulatory pathway plays a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9385de51929b39b89cb79bf7ded570
https://doi.org/10.1016/j.ajpath.2013.02.014

Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Cardiac Allograft Rejection and Vasculopathy

Autor: Hideo Yagita, Shakila Khandwala, Vijay K. Vanguri, Indira Guleria, Mohamed H. Sayegh, Joyce Popoola, Miyuki Azuma, Nidyanandh Vadivel, Tahiro Shin, Shirine Dada, M. Javeed Ansari, Jun Yang, Chaorui Tian, Anil Chandraker, Xueli Yuan

Publikováno v: Circulation. 117:660-669

Background— Allograft vasculopathy is a major limiting factor in the long-term success of cardiac transplantation. T cells play a critical role in initiation of cardiac allograft rejection and allograft vasculopathy. The negative T-cell costimulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2e014387052d91c0a3dd6ee41fefbc
https://doi.org/10.1161/circulationaha.107.741025

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes

Autor: Kenneth Law, Scott J. Rodig, Erxi Wu, Mollie Jurewicz, Andrea Vergani, Kyri Dunussi-Joannopoulos, Masie Wong, Jeffrey A. Bluestone, Reza Abdi, Shirine Dada, Paolo Fiorina, Mohamed H. Sayegh, Ze Tian, Indira Guleria

Publikováno v: Diabetes, vol 57, iss 11
Diabetes

OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice.RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to effectively reverse autoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b538cd27c4ebcffad18e484a0a587c
https://escholarship.org/uc/item/7tj9b6bw

A link between PDL1 and T regulatory cells in fetomaternal tolerance

Autor: Hideo Yagita, Miyuki Azuma, Brian T. Fife, Antje Habicht, Mollie Jurewicz, Mohamed H. Sayegh, Shirine Dada, Indira Guleria

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 179(8)

Acceptance of the fetus expressing allogeneic paternal Ags by the mother is a physiologic model of transplantation tolerance. Various mechanisms contribute to fetal evasion from immune attack by maternal leukocytes. We have recently demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c020a89fccc7391ecf21cdc490ad5ff
https://pubmed.ncbi.nlm.nih.gov/17911606

Diabetes mellitus - basic research

Autor: Sara Cattaneo, Keisuke Satoh, Li Ying, Renate Koppensteiner, Cassia Toledo Bergamaschi, Akira Nishiyama, Ma. Lorena Roldán, Andrew P. Levy, Lislaine A. Wensing, Francesca D'Addio, Maki Takeuchi, Piergiorgio Messa, Benedita Sampaio-Maia, Shigetaka Yoshida, Yoko Saito, Andrea Remuzzi, Hitoshi Nakashima, Elisa Mieko Suemitsu Higa, Maho Watanabe, Fabiola Carrara, Caihong Zeng, Nakhoul Nakhoul, Margaret Gori Mouro, Daniela Corna, Rabea Asleh, Miki Nagase, Hideharu Tanaka, Liliana A. Monasterolo, Romina Pagotto, Michael Brownlee, Jun Okabe, Bi-Cheng Liu, Sho-ichi Yamagishi, Hyung Wook Kim, Mark E. Cooper, Gabriel Cao, Yasuo Kawaba, Carine Prisco Arnoni, Jonathan Barasch, Guoping Zheng, Min Li, Hirotaka Imamaki, Luciana G. Pereira, Akira Sugawara, Masakazu Kohno, Yixin Qian, Tomoko Kawanishi, Manuel Pestana, Hui-Ping Chen, Franck Molina, Silvia Armelloni, Rui Alves, Yanna Dou, Wei-Song Qin, Shinichi Okada, Juliana L. Dreyfuss, Zhangsuo Liu, Seok Joon Shin, Hidenori Arai, Casandra Margarita Monzón, Daniela Rottoli, Reza Abdi, Shan Mou, Alexandre H. Campos, Toru Kita, Li Ya, Hiroshi Kanamori, Yong Gu, Thomas Hoertenhuber, Natsuko Iga, Catia Cerqueira, Shigeru Shibata, Marina Munoz, Maria Pia Rastaldi, Mi Lee, Joanne K. Ferguson, Chi-Chih Hung, Andrea Vergani, Fabio Sangalli, Yiping Wang, Elena Gagliardini, Hassan Kulaksiz, Yukako Kinoshita, Nicolas Salvetat, Li Zhang, Tullio Bertani, Antonio Cabrita, Young Ae Kang, Vincent Lee, Takashige Kuwabara, Daisuke Nakano, Mollie Jurewicz, Toshiro Fujita, Hyun Wha Chung, Rachel Miller-Lotan, Kiyoshi Mori, Muh Geot Wong, Motoaki Saito, Lei-Shi Li, Paula Serrao, Eman El Eter, Yan Qiu, Yi-Mei Hong, Hung-Chun Chen, Christina Maeda Takiya, Romano Nosadini, Birgit Rami, David Harris, Florian Hoellerl, Weier Qi, Zhihong Liu, Ryuji Iwatani, Y. Ogawa, Emi Kazuyama, Mirian A. Boim, Tetsuya Nagae, Kanako Matsubara, Qing Li, Giacomo Garibotto, Li-Min Xu, Kenji Ito, Xiao Ru Huang, Steven J. Harper, Giuseppe Remuzzi, Adelson Marçal Rodrigues, Jiaze Li, Hong-Lang Xie, Takashi Oite, Takuya Ishimura, Margarita Angerosa, Rodrigo Tambellini, Claude Granier, Liu Maodong, Yanling Zhang, Yong-Chun Ge, Ayako Fujimi, Dong Zheng, Yoshimi Takamiya, Mohamed H. Sayegh, Yu-Chi Cheng, Sara Conti, Qingxian Zhang, Hye Kyoung Song, Yu-Yan Fan, Jackson Souza-Menezes, Masashi Mukoyama, Hideki Yokoi, Xin Ming Chen, Ma. Mónica Elías, Zhai Shana, Melina A. Pagotto, Lorena Longaretti, Yonghong Shi, Assam El-Osta, Carol A. Pollock, Zanzhe Yu, Jad Kheir, Yoon Sik Chang, Takao Saito, Maha El Enazy, Laura Giardino, Ya Wang, Aneta Balcerczyk, Raquel C. Castiglione, Alessio Mocci, Sharma Prabhakar, Piotr Ksiazek, Ariela Benigni, Carla Zoja, Edith Schober, Shi Yonghong, Yan Sun, Duo Li, Wei-Wei Zhu, Yi-chun Tsai, Stephen I. Alexander, Seiya Okuda, Qi Cao, Edgar Maquigussa, Cheol Whee Park, Sara Molinas, Takako Mizutani, Kei Fukami, Yusuke Kaida, Paulo Roberto Santos, Jee Han, Lin Tang, Wakako Kawarazaki, Noriko Satoh, Alex Yuri S. Sato, Hui Y. Lan, Anabela Almeida, Zhang Yanling, Zhaohui Ni, David Barit, Susumu Kanzaki, Jiaqi Qian, Yukinori Tamura, Farid Nakhoul, David O. Bates, Fernando Dominici, Arthur C.K. Chung, Shirine Dada, Ying Li, Ji Hee Lim, Leyi Gu, Zhao-Hong Chen, Gastón Rojic, Sungjin Chung, Paolo Fiorina, Felipe M. Ornellas, Dae Cha, Roy Asaf, Huili Dai, Itaru Satoh, Laura Trumper, Masato Kasahara, Kazuwa Nakao, Jorge Giani, Carolina M.L. Barbosa, Oh Yeun Kwon, Atsushi Fukatsu, Jorge Toblli, Weiming Zhan, Alexander J. Szalai, Hoda Awad, Kiyomi Koike, Atsushi Hayashi, Shanyan Lin, Yucheng Yan, Fei Liu, Anna Watson, Sabine Peres, Jun Gao, Andrew H.J. Salmon, Faical Jarraya, Karin Jandeleit-Dahm, Monica Moreira-Rodrigues, Omar P. Pignataro, Gerit-Holger Schernthaner, Andrea Augello, Guntram Schernthaner, Giuseppe Garigali, Marcelo M. Morales, Michal Dragan, Hiroyuki Kobori, Monika Buraczynska, Grazyna Orlowska-Kowalik, Daniella Brasacchio, Janete Quelhas-Santos, Tatiana Maron-GutierrezGutierrez, Seiji Ueda, Guo Quin Wang

Publikováno v: NDT Plus. 2:ii985-ii985

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bb37fccb3e12e90b7bdbceb92e87e9c
https://doi.org/10.1093/ndtplus/2.s2.7