Výsledky vyhledávání - "Shirin Modarai"

Akademický článek

MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies miRNA92a as a Regulator of the LRIG1 Stem Cell Gene

Autor: Vignesh Viswanathan, Lynn Opdenaker, Shirin Modarai, Jeremy Z. Fields, Gregory Gonye, Bruce M. Boman

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8, p 2804 (2020)

MicroRNAs (miRNAs) have a critical role in regulating stem cells (SCs) during development, and because aberrant expression of miRNAs occurs in various cancers, our goal was to determine if dysregulation of miRNAs is involved in the SC origin of color

Externí odkaz: https://doaj.org/article/7942dca659ce4a85841113e8407d3e6f

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'Supplementary Figure Legends' from An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia

Autor: Bruce M. Boman, Greg Gonye, Isidore Rigoutsos, Sepehr Haghighat, Jeremy Fields, Juan Palazzo, Deni Galileo, Pamela Green, Skye Schmidt, Monica Accerbi, Shirin Modarai, Lynn Opdenaker, Tao Zhang, Shirish Damle, Vignesh Viswanathan

'Legends for Supplementary Figures'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ceaeb88d2e16ab37d98c2552a916e9
https://doi.org/10.1158/0008-5472.22415189

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Data from An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia

Malignant transformation of tissue stem cells (SC) may be the root of most cancer. Accordingly, we identified miRNA expression patterns in the normal human colonic SC niche to understand how cancer stem cells (CSC) may arise. In profiling miRNA expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52168199c52a21be52bb304d232a44fe
https://doi.org/10.1158/0008-5472.c.6509195

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Supplemental Table 1: differentially expressed miRNAs in CRC vs normal tissue from An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia

List of 83 miRNAs which were differentially expressed in CRC vs normal colon.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf5512d450617315f719afef5830e8f
https://doi.org/10.1158/0008-5472.22415186

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Supplemental Table 3: predicted gene targets of differentially expressed miRNAs in the upper and bottom crypt and GO term analysis from An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia

Lists of predicted gene targets of miRNAs in the upper crypt. List of predicted gene targets in the crypt bottom. GO term analysis of the top 200 predicted gene targets for both the lists.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2263a26bf7bf653aa61356c163430f01
https://doi.org/10.1158/0008-5472.22415180.v1

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Supplementary Data from An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia

'Fig S1. Validation of miRNA chip results by quantitative PCR analysis. Fig S2. Analysis of differentially expressed miRNAs using target predictions. Fig S3. The relative abundance of the common predicted targets in relation to miRNA levels in CRC ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8337821e819706cf394d6fd0338fbeea
https://doi.org/10.1158/0008-5472.22415177

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Supplemental Table 2: Predicted gene targets of the 16 differentially expressed miRNAs from An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia

* List gives the number of target gene transcripts that are hit by one or more of the miRNAs in order of decreasing number of miRNAs hitting them. **List gives the number of target gene transcripts that are hit by those miRNAs that are over-expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46850f7febf622a9efb805d1c66b8959
https://doi.org/10.1158/0008-5472.22415183

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Exon skipping induced by CRISPR-directed gene editing regulates the response to chemotherapy in non-small cell lung carcinoma cells

Autor: Kelly Banas, Shirin Modarai, Natalia Rivera-Torres, Byung-Chun Yoo, Pawel A. Bialk, Connor Barrett, Mona Batish, Eric B. Kmiec

Publikováno v: Gene therapy. 29(6)

We have been developing CRISPR-directed gene editing as an augmentative therapy for the treatment of non-small cell lung carcinoma (NSCLC) by genetic disruption of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). NRF2 promotes tumor cell survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60abb70a164e4cc02343e9373d17dd7
https://pubmed.ncbi.nlm.nih.gov/35314779

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Abstract 4256: Neuroendocrine, stem, and stromal cell interactions involved in the organization of the normal colonic stem cell niche which become disorganized during colon tumorigenesis

Autor: Lynn Opdenaker, Senem Kurtoglu, Bruce M. Boman, Koree Ahn, Tao Zhang, Shirin Modarai

Publikováno v: Cancer Research. 70:4256-4256

In development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but it is incompletely understood which dysregulated mechanisms cause SC overpopulation. Because neuroendocrine cell (NEC) and SC pop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::954b167a34f7c91f038b00faabc573d6
https://doi.org/10.1158/1538-7445.am10-4256

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